Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Definition

A familial early-onset form of Alzheimer disease. It can be associated with cerebral amyloid angiopathy. Alzheimer disease is a neurodegenerative disorder characterized by progressive dementia, loss of cognitive abilities, and deposition of fibrillar amyloid proteins as intraneuronal neurofibrillary tangles, extracellular amyloid plaques and vascular amyloid deposits. The major constituent of these plaques is the neurotoxic amyloid-beta-APP 40-42 peptide (s), derived proteolytically from the transmembrane precursor protein APP by sequential secretase processing. The cytotoxic C-terminal fragments (CTFs) and the caspase-cleaved products such as C31 derived from APP, are also implicated in neuronal death.

Acronym

AD1

Synonyms

Autosomal dominant Alzheimer disease
Early-onset Alzheimer disease with cerebral amyloid angiopathy

Keywords

Alzheimer disease
Neurodegeneration
Amyloidosis