› What is the difference between the GO annotation included in UniProtKB's "Ontologies" section, and the information accessible via the link "Complete GO annotation"?
› How frequently is UniProt released? What is the synchronization delay with other databases?
› How is protein family membership assigned in UniProtKB?
› How is orthology established in UniProtKB/Swiss-Prot?
The cross-references section of UniProtKB entries displays explicit and implicit links to databases such as nucleotide sequence databases, model organism databases and genomics and proteomics resources. A single entry can have cross-references to several dozen different databases and have several hundred individual links. The databases are categorized for easy user perusal and understanding of how the different databases relate to both UniProtKB and to each other:
› Sequence databases
› 3D structure databases
› Protein-protein interaction databases
› Protein family/group databases
› PTM databases
› Polymorphism databases
› 2D gel databases
› Proteomic databases
› Protocols and materials databases
› Genome annotation databases
› Organism-specific databases
› Phylogenomic databases
› Enzyme and pathway databases
› Gene expression databases
› Family and domain databases
The list of databases that are cross-referenced by UniProt entries is also available as a text file.