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Biglycan is an extracellular MuSK binding protein important for synapse stability.

Amenta A.R., Creely H.E., Mercado M.L., Hagiwara H., McKechnie B.A., Lechner B.E., Rossi S.G., Wang Q., Owens R.T., Marrero E. et al.

J. Neurosci. 32:2324-2334(2012) · Mapped (16)

The proteoglycan biglycan enhances antigen-specific T cell activation potentially via MyD88 and TRIF pathways and triggers autoimmune perimyocarditis.

Popovic Z.V., Wang S., Papatriantafyllou M., Kaya Z., Porubsky S., Meisner M., Bonrouhi M., Burgdorf S., Young M.F., Schaefer L. et al.

J. Immunol. 187:6217-6226(2011) · Mapped (36)

Modulation of canonical Wnt signaling by the extracellular matrix component biglycan.

Berendsen A.D., Fisher L.W., Kilts T.M., Owens R.T., Robey P.G., Gutkind J.S., Young M.F.

Proc. Natl. Acad. Sci. U.S.A. 108:17022-17027(2011) · Mapped (17)

Placental expression of the heme transporter, feline leukemia virus subgroup C receptor, is related to maternal iron status in pregnant adolescents.

Jaacks L.M., Young M.F., Essley B.V., McNanley T.J., Cooper E.M., Pressman E.K., McIntyre A.W., Orlando M.S., Abkowitz J.L., Guillet R. et al.

J. Nutr. 141:1267-1272(2011) · Mapped (2)

Deficiency of biglycan causes cardiac fibroblasts to differentiate into a myofibroblast phenotype.

Melchior-Becker A., Dai G., Ding Z., Schafer L., Schrader J., Young M.F., Fischer J.W.

J. Biol. Chem. 286:17365-17375(2011) · Mapped (8)

The proteoglycan biglycan regulates expression of the B cell chemoattractant CXCL13 and aggravates murine lupus nephritis.

Moreth K., Brodbeck R., Babelova A., Gretz N., Spieker T., Zeng-Brouwers J., Pfeilschifter J., Young M.F., Schaefer R.M., Schaefer L.

J. Clin. Invest. 120:4251-4272(2010) · Mapped (17)

WISP-1/CCN4 regulates osteogenesis by enhancing BMP-2 activity.

Ono M., Inkson C.A., Kilts T.M., Young M.F.

J. Bone Miner. Res. 26:193-208(2011) · Mapped (10)

Biglycan and fibromodulin have essential roles in regulating chondrogenesis and extracellular matrix turnover in temporomandibular joint osteoarthritis.

Embree M.C., Kilts T.M., Ono M., Inkson C.A., Syed-Picard F., Karsdal M.A., Oldberg A., Bi Y., Young M.F.

Am. J. Pathol. 176:812-826(2010) · Mapped (11)

Absence of biglycan accelerates the degenerative process in mouse intervertebral disc.

Furukawa T., Ito K., Nuka S., Hashimoto J., Takei H., Takahara M., Ogino T., Young M.F., Shinomura T.

Spine 34:E911-7(2009) · Mapped (6)

Biglycan, a danger signal that activates the NLRP3 inflammasome via toll-like and P2X receptors.

Babelova A., Moreth K., Tsalastra-Greul W., Zeng-Brouwers J., Eickelberg O., Young M.F., Bruckner P., Pfeilschifter J., Schaefer R.M., Grone H.J. et al.

J. Biol. Chem. 284:24035-24048(2009) · Mapped (14)

Potential roles for the small leucine-rich proteoglycans biglycan and fibromodulin in ectopic ossification of tendon induced by exercise and in modulating rotarod performance.

Kilts T., Ameye L., Syed-Picard F., Ono M., Berendsen A.D., Oldberg A., Heegaard A.M., Bi Y., Young M.F.

Scand J Med Sci Sports 19:536-546(2009) · Mapped (15)

Genetic evidence for key roles of decorin and biglycan in dentin mineralization.

Haruyama N., Sreenath T.L., Suzuki S., Yao X., Wang Z., Wang Y., Honeycutt C., Iozzo R.V., Young M.F., Kulkarni A.B.

Matrix Biol. 28:129-136(2009) · Mapped (15)

Genetic evidence for the coordinated regulation of collagen fibrillogenesis in the cornea by decorin and biglycan.

Zhang G., Chen S., Goldoni S., Calder B.W., Simpson H.C., Owens R.T., McQuillan D.J., Young M.F., Iozzo R.V., Birk D.E.

J. Biol. Chem. 284:8888-8897(2009) · Mapped (11)

The potential functional interaction of biglycan and WISP-1 in controlling differentiation and proliferation of osteogenic cells.

Inkson C.A., Ono M., Bi Y., Kuznetsov S.A., Fisher L.W., Young M.F.

Cells Tissues Organs (Print) 189:153-157(2009) · Mapped (10)

Impact on bone of an estrogen receptor-alpha gene loss of function mutation.

Smith E.P., Specker B., Bachrach B.E., Kimbro K.S., Li X.J., Young M.F., Fedarko N.S., Abuzzahab M.J., Frank G.R., Cohen R.M. et al.

J. Clin. Endocrinol. Metab. 93:3088-3096(2008) · Mapped (58)

TGF-beta1 and WISP-1/CCN-4 can regulate each other's activity to cooperatively control osteoblast function.

Inkson C.A., Ono M., Kuznetsov S.A., Fisher L.W., Robey P.G., Young M.F.

J. Cell. Biochem. 104:1865-1878(2008) · Mapped (13)

Biglycan is required for adaptive remodeling after myocardial infarction.

Westermann D., Mersmann J., Melchior A., Freudenberger T., Petrik C., Schaefer L., Lullmann-Rauch R., Lettau O., Jacoby C., Schrader J. et al.

Circulation 117:1269-1276(2008) · Mapped (6)

Normal binding of lipoprotein lipase, chylomicrons, and apo-AV to GPIHBP1 containing a G56R amino acid substitution.

Gin P., Beigneux A.P., Davies B., Young M.F., Ryan R.O., Bensadoun A., Fong L.G., Young S.G.

Biochim. Biophys. Acta 1771:1464-1468(2007) · UniProtKB (3) · Mapped (10)

Identification of tendon stem/progenitor cells and the role of the extracellular matrix in their niche.

Bi Y., Ehirchiou D., Kilts T.M., Inkson C.A., Embree M.C., Sonoyama W., Li L., Leet A.I., Seo B.M., Zhang L. et al.

Nat. Med. 13:1219-1227(2007) · Mapped (11)

Biglycan deficiency causes spontaneous aortic dissection and rupture in mice.

Heegaard A.M., Corsi A., Danielsen C.C., Nielsen K.L., Jorgensen H.L., Riminucci M., Young M.F., Bianco P.

Circulation 115:2731-2738(2007) · Mapped (6)

Impaired posterior frontal sutural fusion in the biglycan/decorin double deficient mice.

Wadhwa S., Bi Y., Ortiz A.T., Embree M.C., Kilts T., Iozzo R., Opperman L.A., Young M.F.

Bone 40:861-866(2007) · Mapped (11)

Biglycan binds to alpha- and gamma-sarcoglycan and regulates their expression during development.

Rafii M.S., Hagiwara H., Mercado M.L., Seo N.S., Xu T., Dugan T., Owens R.T., Hook M., McQuillan D.J., Young M.F. et al.

J. Cell. Physiol. 209:439-447(2006) · Mapped (22)

Mice deficient in biglycan and fibromodulin as a model for temporomandibular joint osteoarthritis.

Wadhwa S., Embree M., Ameye L., Young M.F.

Cells Tissues Organs (Print) 181:136-143(2005) · Mapped (11)

The mechanical phenotype of biglycan-deficient mice is bone- and gender-specific.

Wallace J.M., Rajachar R.M., Chen X.D., Shi S., Allen M.R., Bloomfield S.A., Les C.M., Robey P.G., Young M.F., Kohn D.H.

Bone 39:106-116(2006) · Mapped (6)

Biglycan deficiency increases osteoclast differentiation and activity due to defective osteoblasts.

Bi Y., Nielsen K.L., Kilts T.M., Yoon A., A Karsdal M., Wimer H.F., Greenfield E.M., Heegaard A.M., Young M.F.

Bone 38:778-786(2006) · Mapped (6)

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