| Structural characterization of a unique interface between carbohydrate response element-binding protein (ChREBP) and 14-3-3beta protein. Ge Q., Huang N., Wynn R.M., Li Y., Du X., Miller B., Zhang H., Uyeda K.
J. Biol. Chem. 287:41914-41921(2012) · Mapped (3) |
| Structural and biochemical characterization of human mitochondrial branched-chain alpha-ketoacid dehydrogenase phosphatase. Wynn R.M., Li J., Brautigam C.A., Chuang J.L., Chuang D.T.
J. Biol. Chem. 287:9178-9192(2012) · Mapped (1) |
| Importin-alpha protein binding to a nuclear localization signal of carbohydrate response element-binding protein (ChREBP). Ge Q., Nakagawa T., Wynn R.M., Chook Y.M., Miller B.C., Uyeda K.
J. Biol. Chem. 286:28119-28127(2011) · Mapped (3) |
| Structural and thermodynamic basis for weak interactions between dihydrolipoamide dehydrogenase and subunit-binding domain of the branched-chain alpha-ketoacid dehydrogenase complex. Brautigam C.A., Wynn R.M., Chuang J.L., Naik M.T., Young B.B., Huang T.H., Chuang D.T.
J. Biol. Chem. 286:23476-23488(2011) · Mapped (6) |
| Coordinate regulation/localization of the carbohydrate responsive binding protein (ChREBP) by two nuclear export signal sites: discovery of a new leucine-rich nuclear export signal site. Fukasawa M., Ge Q., Wynn R.M., Ishii S., Uyeda K.
Biochem. Biophys. Res. Commun. 391:1166-1169(2010) |
| Branched-chain amino acid metabolon: interaction of glutamate dehydrogenase with the mitochondrial branched-chain aminotransferase (BCATm). Islam M.M., Nautiyal M., Wynn R.M., Mobley J.A., Chuang D.T., Hutson S.M.
J. Biol. Chem. 285:265-276(2010) · Mapped (4) |
| Maple syrup urine disease in Cypriot families: identification of three novel mutations and biochemical characterization of the p.Thr211Met mutation in the E1alpha subunit. Georgiou T., Chuang J.L., Wynn R.M., Stylianidou G., Korson M., Chuang D.T., Drousiotou A.
Genet Test Mol Biomarkers 13:657-664(2009) · Mapped (6) |
| Structural basis for inactivation of the human pyruvate dehydrogenase complex by phosphorylation: role of disordered phosphorylation loops. Kato M., Wynn R.M., Chuang J.L., Tso S.C., Machius M., Li J., Chuang D.T.
Structure 16:1849-1859(2008) · UniProtKB (2) |
| Pyruvate dehydrogenase kinase-4 structures reveal a metastable open conformation fostering robust core-free basal activity. Wynn R.M., Kato M., Chuang J.L., Tso S.C., Li J., Chuang D.T.
J. Biol. Chem. 283:25305-25315(2008) · UniProtKB (1) · Mapped (4) |
| Regulation of nuclear import/export of carbohydrate response element-binding protein (ChREBP): interaction of an alpha-helix of ChREBP with the 14-3-3 proteins and regulation by phosphorylation. Sakiyama H., Wynn R.M., Lee W.R., Fukasawa M., Mizuguchi H., Gardner K.H., Repa J.J., Uyeda K.
J. Biol. Chem. 283:24899-24908(2008) · Mapped (15) |
| The two active sites in human branched-chain alpha-keto acid dehydrogenase operate independently without an obligatory alternating-site mechanism. Li J., Machius M., Chuang J.L., Wynn R.M., Chuang D.T.
J. Biol. Chem. 282:11904-11913(2007) · Mapped (7) |
| A synchronized substrate-gating mechanism revealed by cubic-core structure of the bovine branched-chain alpha-ketoacid dehydrogenase complex. Kato M., Wynn R.M., Chuang J.L., Brautigam C.A., Custorio M., Chuang D.T.
EMBO J. 25:5983-5994(2006) · UniProtKB (1) |
| A versatile conformational switch regulates reactivity in human branched-chain alpha-ketoacid dehydrogenase. Machius M., Wynn R.M., Chuang J.L., Li J., Kluger R., Yu D., Tomchick D.R., Brautigam C.A., Chuang D.T.
Structure 14:287-298(2006) · Mapped (7) |
| Structural insight into interactions between dihydrolipoamide dehydrogenase (E3) and E3 binding protein of human pyruvate dehydrogenase complex. Brautigam C.A., Wynn R.M., Chuang J.L., Machius M., Tomchick D.R., Chuang D.T.
Structure 14:611-621(2006) · UniProtKB (2) · Mapped (6) |
| Crystal structure of pyruvate dehydrogenase kinase 3 bound to lipoyl domain 2 of human pyruvate dehydrogenase complex. Kato M., Chuang J.L., Tso S.C., Wynn R.M., Chuang D.T.
EMBO J. 24:1763-1774(2005) · UniProtKB (2) |
| Molecular mechanism for regulation of the human mitochondrial branched-chain alpha-ketoacid dehydrogenase complex by phosphorylation. Wynn R.M., Kato M., Machius M., Chuang J.L., Li J., Tomchick D.R., Chuang D.T.
Structure 12:2185-2196(2004) · Mapped (2) |
| Cross-talk between thiamin diphosphate binding and phosphorylation loop conformation in human branched-chain alpha-keto acid decarboxylase/dehydrogenase. Li J., Wynn R.M., Machius M., Chuang J.L., Karthikeyan S., Tomchick D.R., Chuang D.T.
J. Biol. Chem. 279:32968-32978(2004) · Mapped (7) |
| Roles of His291-alpha and His146-beta' in the reductive acylation reaction catalyzed by human branched-chain alpha-ketoacid dehydrogenase: refined phosphorylation loop structure in the active site. Wynn R.M., Machius M., Chuang J.L., Li J., Tomchick D.R., Chuang D.T.
J. Biol. Chem. 278:43402-43410(2003) · Mapped (9) |
| Structure of rat BCKD kinase: nucleotide-induced domain communication in a mitochondrial protein kinase. Machius M., Chuang J.L., Wynn R.M., Tomchick D.R., Chuang D.T.
Proc. Natl. Acad. Sci. U.S.A. 98:11218-11223(2001) · Mapped (1) |
| Biochemical basis of type IB (E1beta ) mutations in maple syrup urine disease. A prevalent allele in patients from the Druze kindred in Israel. Wynn R.M., Chuang J.L., Sansaricq C., Mandel H., Chuang D.T.
J. Biol. Chem. 276:36550-36556(2001) · Mapped (2) |
| Roles of active site and novel K+ ion-binding site residues in human mitochondrial branched-chain alpha-ketoacid decarboxylase/dehydrogenase. Wynn R.M., Ho R., Chuang J.L., Chuang D.T.
J. Biol. Chem. 276:4168-4174(2001) · Mapped (2) |
| Crystal structure of human branched-chain alpha-ketoacid dehydrogenase and the molecular basis of multienzyme complex deficiency in maple syrup urine disease. Aevarsson A., Chuang J.L., Wynn R.M., Turley S., Chuang D.T., Hol W.G.J.
Structure 8:277-291(2000) · UniProtKB (1) · Mapped (1) |
| Differential processing of human and rat E1 alpha precursors of the branched-chain alpha-keto acid dehydrogenase complex caused by an N-terminal proline in the rat sequence. Wynn R.M., Kochi H., Cox R.P., Chuang D.T.
Biochim. Biophys. Acta 1201:125-128(1994) · UniProtKB (3) |
| Molecular and biochemical basis of intermediate maple syrup urine disease: occurrence of homozygous G245R and F364C mutations at the E1-alpha locus of Hispanic-Mexican patients. Chuang J.L., Davie J.R., Chinsky J.M., Wynn R.M., Cox R.P., Chuang D.T.
J. Clin. Invest. 95:954-963(1995) · UniProtKB (1) |
| Expression and characterization of branched-chain alpha-ketoacid dehydrogenase kinase from the rat. Is it a histidine-protein kinase? Davie J.R., Wynn R.M., Meng M., Huang Y.-S., Aalund G., Chuang D.T., Lau K.S.
J. Biol. Chem. 270:19861-19867(1995) · UniProtKB (1) |
