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Oxaloacetate supplementation increases lifespan in C. elegans through an AMPK/FOXO-dependent pathway.

Williams D.S., Cash A., Hamadani L., Diemer T.

Aging Cell 0:0-0(2009) · Mapped (3)

Loss of mitogen-activated protein kinase kinase kinase 4 (MAP3K4) reveals a requirement for MAPK signalling in mouse sex determination.

Bogani D., Siggers P., Brixey R., Warr N., Beddow S., Edwards J., Williams D., Wilhelm D., Koopman P., Flavell R.A. et al.

PLoS Biol. 7:e1000196-e1000196(2009) · Mapped (95)

Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potential.

Xu H., Eleswarapu S., Geiger H., Szczur K., Daria D., Zheng Y., Settleman J., Srour E.F., Williams D.A., Filippi M.D.

Blood 114:3557-3566(2009) · Mapped (4)

Flipping of alkylated DNA damage bridges base and nucleotide excision repair.

Tubbs J.L., Latypov V., Kanugula S., Butt A., Melikishvili M., Kraehenbuehl R., Fleck O., Marriott A., Watson A.J., Verbeek B. et al.

Nature 459:808-813(2009) · Mapped (1)

Excitotoxic-mediated transcriptional decreases in HCN2 channel function increase network excitability in CA1.

Adams B.E., Reid C.A., Myers D., Ng C., Powell K., Phillips A.M., Zheng T., O'Brien T.J., Williams D.A.

Exp. Neurol. 219:249-257(2009) · Mapped (1)

The glucose transporter 2 undergoes plasma membrane endocytosis and lysosomal degradation in a secretagogue-dependent manner.

Hou J.C., Williams D., Vicogne J., Pessin J.E.

Endocrinology 150:4056-4064(2009) · Mapped (1)

Characterization of Arabidopsis 6-phosphogluconolactonase T-DNA insertion mutants reveals an essential role for the oxidative section of the plastidic pentose phosphate pathway in plant growth and development.

Xiong Y., DeFraia C., Williams D., Zhang X., Mou Z.

Plant Cell Physiol. 50:1277-1291(2009) · Mapped (2)

Harmonin mutations cause mechanotransduction defects in cochlear hair cells.

Grillet N., Xiong W., Reynolds A., Kazmierczak P., Sato T., Lillo C., Dumont R.A., Hintermann E., Sczaniecka A., Schwander M. et al.

Neuron 62:375-387(2009) · Mapped (2)

Biomphalaria glabrata peroxiredoxin: effect of schistosoma mansoni infection on differential gene regulation.

Knight M., Raghavan N., Goodall C., Cousin C., Ittiprasert W., Sayed A., Miller A., Williams D.L., Bayne C.J.

Mol. Biochem. Parasitol. 167:20-31(2009) · UniProtKB (5)

Impaired FANCD2 monoubiquitination and hypersensitivity to camptothecin uniquely characterize Fanconi anemia complementation group M.

Singh T.R., Bakker S.T., Agarwal S., Jansen M., Grassman E., Godthelp B.C., Ali A.M., Du C.H., Rooimans M.A., Fan Q. et al.

Blood 114:174-180(2009) · Mapped (3)

Analysis of SEC9 suppression reveals a relationship of SNARE function to cell physiology.

Williams D.C., Novick P.J.

PLoS ONE 4:e5449-e5449(2009) · Mapped (11)

Axonal stress kinase activation and tau misbehavior induced by kinesin-1 transport defects.

Falzone T.L., Stokin G.B., Lillo C., Rodrigues E.M., Westerman E.L., Williams D.S., Goldstein L.S.

J. Neurosci. 29:5758-5767(2009) · Mapped (12)

Characterization of sulfoxygenation and structural implications of human flavin-containing monooxygenase isoform 2 (FMO2.1) variants S195L and N413K.

Krueger S.K., Henderson M.C., Siddens L.K., VanDyke J.E., Benninghoff A.D., Karplus P.A., Furnes B., Schlenk D., Williams D.E.

Drug Metab. Dispos. 37:1785-1791(2009) · Mapped (5)

Differential roles of TLR2 and TLR4 in acute focal cerebral ischemia/reperfusion injury in mice.

Hua F., Ma J., Ha T., Kelley J.L., Kao R.L., Schweitzer J.B., Kalbfleisch J.H., Williams D.L., Li C.

Brain Res. 1262:100-108(2009) · Mapped (6)

Selective inhibition of proliferation in colorectal carcinoma cell lines expressing mutant APC or activated B-Raf.

Zhang H.H., Walker F., Kiflemariam S., Whitehead R.H., Williams D., Phillips W.A., Mikeska T., Dobrovic A., Burgess A.W.

Int. J. Cancer 125:297-307(2009) · Mapped (12)

Retinal pigment epithelium defects in humans and mice with mutations in MYO7A: imaging melanosome-specific autofluorescence.

Gibbs D., Cideciyan A.V., Jacobson S.G., Williams D.S.

Invest. Ophthalmol. Vis. Sci. 50:4386-4393(2009) · Mapped (7)

The P2X7 receptor drives microglial activation and proliferation: a trophic role for P2X7R pore.

Monif M., Reid C.A., Powell K.L., Smart M.L., Williams D.A.

J. Neurosci. 29:3781-3791(2009) · Mapped (1)

Muscle-specific differences in the response of mitochondrial proteins to beta-GPA feeding: an evaluation of potential mechanisms.

Williams D.B., Sutherland L.N., Bomhof M.R., Basaraba S.A., Thrush A.B., Dyck D.J., Field C.J., Wright D.C.

Am. J. Physiol. Endocrinol. Metab. 296:E1400-8(2009) · Mapped (3)

Reciprocal regulation of IL-23 and IL-12 following co-activation of Dectin-1 and TLR signaling pathways.

Dennehy K.M., Willment J.A., Williams D.L., Brown G.D.

Eur. J. Immunol. 39:1379-1386(2009) · Mapped (13)

Ectopic HOXB4 overcomes the inhibitory effect of tumor necrosis factor-{alpha} on Fanconi anemia hematopoietic stem and progenitor cells.

Milsom M.D., Schiedlmeier B., Bailey J., Kim M.O., Li D., Jansen M., Ali A.M., Kirby M., Baum C., Fairbairn L.J. et al.

Blood 113:5111-5120(2009) · Mapped (5)

Tristetraprolin mediates interferon-gamma mRNA decay.

Ogilvie R.L., Sternjohn J.R., Rattenbacher B., Vlasova I.A., Williams D.A., Hau H.H., Blackshear P.J., Bohjanen P.R.

J. Biol. Chem. 284:11216-11223(2009) · Mapped (16)

Melanoregulin (MREG) modulates lysosome function in pigment epithelial cells.

Damek-Poprawa M., Diemer T., Lopes V.S., Lillo C., Harper D.C., Marks M.S., Wu Y., Sparrow J.R., Rachel R.A., Williams D.S. et al.

J. Biol. Chem. 284:10877-10889(2009) · Mapped (1)

Vav1 and PI3K are required for phagocytosis of beta-glucan and subsequent superoxide generation by microglia.

Shah V.B., Ozment-Skelton T.R., Williams D.L., Keshvara L.

Mol. Immunol. 46:1845-1853(2009) · Mapped (22)

Mouse hitchhiker mutants have spina bifida, dorso-ventral patterning defects and polydactyly: identification of Tulp3 as a novel negative regulator of the Sonic hedgehog pathway.

Patterson V.L., Damrau C., Paudyal A., Reeve B., Grimes D.T., Stewart M.E., Williams D.J., Siggers P., Greenfield A., Murdoch J.N.

Hum. Mol. Genet. 18:1719-1739(2009) · Mapped (75)

Diverse cell-specific expression of myoglobin isoforms in brain, kidney, gill and liver of the hypoxia-tolerant carp and zebrafish.

Cossins A.R., Williams D.R., Foulkes N.S., Berenbrink M., Kipar A.

J. Exp. Biol. 212:627-638(2009) · Mapped (2)

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