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The Src family kinases and protein kinase C synergize to mediate Gq-dependent platelet activation.

Xiang B., Zhang G., Stefanini L., Bergmeier W., Gartner T.K., Whiteheart S.W., Li Z.

J. Biol. Chem. 287:41277-41287(2012) · Mapped (29)

Munc18b/STXBP2 is required for platelet secretion.

Al Hawas R., Ren Q., Ye S., Karim Z.A., Filipovich A.H., Whiteheart S.W.

Blood 120:2493-2500(2012) · Mapped (4)

Syntaxin-11, but not syntaxin-2 or syntaxin-4, is required for platelet secretion.

Ye S., Karim Z.A., Al Hawas R., Pessin J.E., Filipovich A.H., Whiteheart S.W.

Blood 120:2484-2492(2012) · Mapped (8)

Reduction of vesicle-associated membrane protein 2 expression leads to a kindling-resistant phenotype in a murine model of epilepsy.

Matveeva E.A., Price D.A., Whiteheart S.W., Vanaman T.C., Gerhardt G.A., Slevin J.T.

Neuroscience 202:77-86(2012) · Mapped (4)

Distinct roles for Rap1b protein in platelet secretion and integrin alphaIIbbeta3 outside-in signaling.

Zhang G., Xiang B., Ye S., Chrzanowska-Wodnicka M., Morris A.J., Gartner T.K., Whiteheart S.W., White G.C., Smyth S.S., Li Z.

J. Biol. Chem. 286:39466-39477(2011) · Mapped (2)

A novel role for platelet secretion in angiogenesis: mediating bone marrow-derived cell mobilization and homing.

Feng W., Madajka M., Kerr B.A., Mahabeleshwar G.H., Whiteheart S.W., Byzova T.V.

Blood 117:3893-3902(2011) · Mapped (15)

Munc13-4 is a limiting factor in the pathway required for platelet granule release and hemostasis.

Ren Q., Wimmer C., Chicka M.C., Ye S., Ren Y., Hughson F.M., Whiteheart S.W.

Blood 116:869-877(2010) · Mapped (4)

VAMP8/endobrevin is overexpressed in hyperreactive human platelets: suggested role for platelet microRNA.

Kondkar A.A., Bray M.S., Leal S.M., Nagalla S., Liu D.J., Jin Y., Dong J.F., Ren Q., Whiteheart S.W., Shaw C. et al.

J. Thromb. Haemost. 8:369-378(2010) · Mapped (1)

Endobrevin/VAMP-8-dependent dense granule release mediates thrombus formation in vivo.

Graham G.J., Ren Q., Dilks J.R., Blair P., Whiteheart S.W., Flaumenhaft R.

Blood 114:1083-1090(2009) · Mapped (3)

PKCalpha regulates platelet granule secretion and thrombus formation in mice.

Konopatskaya O., Gilio K., Harper M.T., Zhao Y., Cosemans J.M., Karim Z.A., Whiteheart S.W., Molkentin J.D., Verkade P., Watson S.P. et al.

J. Clin. Invest. 119:399-407(2009) · UniProtKB (1) · Mapped (3)

Primary platelet signaling cascades and integrin-mediated signaling control ADP-ribosylation factor (Arf) 6-GTP levels during platelet activation and aggregation.

Karim Z.A., Choi W., Whiteheart S.W.

J. Biol. Chem. 283:11995-12003(2008) · Mapped (9)

Endobrevin/VAMP-8 is the primary v-SNARE for the platelet release reaction.

Ren Q., Barber H.K., Crawford G.L., Karim Z.A., Zhao C., Choi W., Wang C.C., Hong W., Whiteheart S.W.

Mol. Biol. Cell 18:24-33(2007) · Mapped (7)

Demonstration of differential quantitative requirements for NSF among multiple vesicle fusion pathways of GLUT4 using a dominant-negative ATPase-deficient NSF.

Chen X., Matsumoto H., Hinck C.S., Al-Hasani H., St-Denis J.F., Whiteheart S.W., Cushman S.W.

Biochem. Biophys. Res. Commun. 333:28-34(2005) · Mapped (5)

Mast cell degranulation requires N-ethylmaleimide-sensitive factor-mediated SNARE disassembly.

Puri N., Kruhlak M.J., Whiteheart S.W., Roche P.A.

J. Immunol. 171:5345-5352(2003) · Mapped (15)

A role for Sec1/Munc18 proteins in platelet exocytosis.

Schraw T.D., Lemons P.P., Dean W.L., Whiteheart S.W.

Biochem. J. 374:207-217(2003)

Granule stores from cellubrevin/VAMP-3 null mouse platelets exhibit normal stimulus-induced release.

Schraw T.D., Rutledge T.W., Crawford G.L., Bernstein A.M., Kalen A.L., Pessin J.E., Whiteheart S.W.

Blood 102:1716-1722(2003) · Mapped (1)

SNAP-23 is a target for calpain cleavage in activated platelets.

Rutledge T.W., Whiteheart S.W.

J. Biol. Chem. 277:37009-37015(2002) · Mapped (5)

Gaf-1, a gamma-SNAP-binding protein associated with the mitochondria.

Chen D., Xu W., He P., Medrano E.E., Whiteheart S.W.

J. Biol. Chem. 276:13127-13135(2001) · UniProtKB (2)

Crystal structure of the amino-terminal domain of N-ethylmaleimide-sensitive fusion protein.

May A.P., Misura K.M., Whiteheart S.W., Weis W.I.

Nat. Cell Biol. 1:175-182(1999) · UniProtKB (1)

Analyses of proteins involved in vesicular trafficking in platelets of mouse models of Hermansky Pudlak syndrome.

Richards-Smith B., Novak E.K., Jang E.K., He P., Haslam R.J., Castle D., Whiteheart S.W., Swank R.T.

Mol. Genet. Metab. 68:14-23(1999) · Mapped (31)

Identification of a cellubrevin/vesicle associated membrane protein 3 homologue in human platelets.

Bernstein A.M., Whiteheart S.W.

Blood 93:571-579(1999) · UniProtKB (1) · Mapped (1)

Crystal structure of the hexamerization domain of N-ethylmaleimide-sensitive fusion protein.

Lenzen C.U., Steinmann D., Whiteheart S.W., Weis W.I.

Cell 94:525-536(1998) · UniProtKB (1)

Regulated secretion in platelets: identification of elements of the platelet exocytosis machinery.

Lemons P.P., Chen D., Bernstein A.M., Bennett M.K., Whiteheart S.W.

Blood 90:1490-1500(1997) · UniProtKB (2)

Proteins involved in synaptic vesicle docking and fusion.

Burns M.E., Beushausen S.A., Chin G.J., Tang D., DeBello W.M., Dresbach T., O'Connor V., Schweizer F.E., Wang S.S., Whiteheart S.W.

Cold Spring Harb. Symp. Quant. Biol. 60:337-348(1995) · UniProtKB (1) · Mapped (1)

SNAP family of NSF attachment proteins includes a brain-specific isoform.

Whiteheart S.W., Griff I.C., Brunner M., Clary D.O., Mayer T., Buhrow S.A., Rothman J.E.

Nature 362:353-355(1993) · UniProtKB (4)

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