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for author:"Waterman M.R."
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| The first virally encoded cytochrome p450. Lamb D.C., Lei L., Warrilow A.G., Lepesheva G.I., Mullins J.G., Waterman M.R., Kelly S.L. J. Virol. 83:8266-8269(2009) · UniProtKB (1) |
| Aromatase is phosphorylated in situ at serine-118. Miller T.W., Shin I., Kagawa N., Evans D.B., Waterman M.R., Arteaga C.L. J. Steroid Biochem. Mol. Biol. 112:95-101(2008) · Mapped (9) |
| Association of a CYP4A11 variant and blood pressure in black men. Gainer J.V., Lipkowitz M.S., Yu C., Waterman M.R., Dawson E.P., Capdevila J.H., Brown N.J. J. Am. Soc. Nephrol. 19:1606-1612(2008) · Mapped (5) |
| The T8590C polymorphism of CYP4A11 and 20-hydroxyeicosatetraenoic acid in essential hypertension. Laffer C.L., Gainer J.V., Waterman M.R., Capdevila J.H., Laniado-Schwartzman M., Nasjletti A., Brown N.J., Elijovich F. Hypertension 51:767-772(2008) · Mapped (5) |
| Purification and functional characterization of human 11beta hydroxylase expressed in Escherichia coli. Zollner A., Kagawa N., Waterman M.R., Nonaka Y., Takio K., Shiro Y., Hannemann F., Bernhardt R. FEBS J. 275:799-810(2008) · Mapped (8) |
| Small-molecule scaffolds for CYP51 inhibitors identified by high-throughput screening and defined by X-ray crystallography. Podust L.M., von Kries J.P., Eddine A.N., Kim Y., Yermalitskaya L.V., Kuehne R., Ouellet H., Warrier T., Altekoster M., Lee J.S. et al. Antimicrob. Agents Chemother. 51:3915-3923(2007) · Mapped (1) |
| Different binding modes of two flaviolin substrate molecules in cytochrome P450 158A1 (CYP158A1) compared to CYP158A2. Zhao B., Lamb D.C., Lei L., Kelly S.L., Yuan H., Hachey D.L., Waterman M.R. Biochemistry 46:8725-8733(2007) · Mapped (1) |
| The structural basis for substrate anchoring, active site selectivity, and product formation by P450 PikC from Streptomyces venezuelae. Sherman D.H., Li S., Yermalitskaya L.V., Kim Y., Smith J.A., Waterman M.R., Podust L.M. J. Biol. Chem. 281:26289-26297(2006) · Mapped (1) |
| Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel. Nakagawa K., Holla V.R., Wei Y., Wang W.H., Gatica A., Wei S., Mei S., Miller C.M., Cha D.R., Price E. Jr. et al. J. Clin. Invest. 116:1696-1702(2006) · Mapped (5) |
| Raman evidence for specific substrate-induced structural changes in the heme pocket of human cytochrome P450 aromatase during the three consecutive oxygen activation steps. Tosha T., Kagawa N., Ohta T., Yoshioka S., Waterman M.R., Kitagawa T. Biochemistry 45:5631-5640(2006) · Mapped (9) |
| Mechanistic analysis of a multiple product sterol methyltransferase implicated in ergosterol biosynthesis in Trypanosoma brucei. Zhou W., Lepesheva G.I., Waterman M.R., Nes W.D. J. Biol. Chem. 281:6290-6296(2006) · UniProtKB (1) · Mapped (1) |
| A second FMN binding site in yeast NADPH-cytochrome P450 reductase suggests a mechanism of electron transfer by diflavin reductases. Lamb D.C., Kim Y., Yermalitskaya L.V., Yermalitsky V.N., Lepesheva G.I., Kelly S.L., Waterman M.R., Podust L.M. Structure 14:51-61(2006) · UniProtKB (1) |
| CYP51 from Trypanosoma cruzi: a phyla-specific residue in the B' helix defines substrate preferences of sterol 14alpha-demethylase. Lepesheva G.I., Zaitseva N.G., Nes W.D., Zhou W., Arase M., Liu J., Hill G.C., Waterman M.R. J. Biol. Chem. 281:3577-3585(2006) · UniProtKB (1) |
| Role of active site water molecules and substrate hydroxyl groups in oxygen activation by cytochrome P450 158A2: a new mechanism of proton transfer. Zhao B., Guengerich F.P., Voehler M., Waterman M.R. J. Biol. Chem. 280:42188-42197(2005) · Mapped (1) |
| Sterol 14 alpha-demethylase, an abundant and essential mixed-function oxidase. Waterman M.R., Lepesheva G.I. Biochem. Biophys. Res. Commun. 338:418-422(2005) · Mapped (1) |
| Binding of two flaviolin substrate molecules, oxidative coupling, and crystal structure of Streptomyces coelicolor A3(2) cytochrome P450 158A2. Zhao B., Guengerich F.P., Bellamine A., Lamb D.C., Izumikawa M., Lei L., Podust L.M., Sundaramoorthy M., Kalaitzis J.A., Reddy L.M. et al. J. Biol. Chem. 280:11599-11607(2005) · UniProtKB (1) |
| Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension. Gainer J.V., Bellamine A., Dawson E.P., Womble K.E., Grant S.W., Wang Y., Cupples L.A., Guo C.-Y., Demissie S., O'Donnell C.J. et al. |
| Structural diversities of active site in clinical azole-bound forms between sterol 14alpha-demethylases (CYP51s) from human and Mycobacterium tuberculosis. Matsuura K., Yoshioka S., Tosha T., Hori H., Ishimori K., Kitagawa T., Morishima I., Kagawa N., Waterman M.R. J. Biol. Chem. 280:9088-9096(2005) · Mapped (2) |
| Estriol bound and ligand-free structures of sterol 14alpha-demethylase. Podust L.M., Yermalitskaya L.V., Lepesheva G.I., Podust V.N., Dalmasso E.A., Waterman M.R. Structure 12:1937-1945(2004) · Mapped (1) |
| Characterization of stable human aromatase expressed in E. coli. Kagawa N., Hori H., Waterman M.R., Yoshioka S. Steroids 69:235-243(2004) · Mapped (9) |
| Comparison of the 1.85 A structure of CYP154A1 from Streptomyces coelicolor A3(2) with the closely related CYP154C1 and CYPs from antibiotic biosynthetic pathways. Podust L.M., Bach H., Kim Y., Lamb D.C., Arase M., Sherman D.H., Kelly S.L., Waterman M.R. Protein Sci. 13:255-268(2004) · UniProtKB (1) |
| Lanosterol metabolism and sterol regulatory element binding protein (SREBP) expression in male germ cell maturation. Fon Tacer K., Kalanj-Bognar S., Waterman M.R., Rozman D. J. Steroid Biochem. Mol. Biol. 85:429-438(2003) · Mapped (2) |
| Transcriptional complexes at the CYP17 CRS. Sewer M.B., Waterman M.R. Endocr. Res. 28:551-558(2002) · Mapped (3) |
| The 1.92-A structure of Streptomyces coelicolor A3(2) CYP154C1. A new monooxygenase that functionalizes macrolide ring systems. Podust L.M., Kim Y., Arase M., Neely B.A., Beck B.J., Bach H., Sherman D.H., Lamb D.C., Kelly S.L., Waterman M.R. J. Biol. Chem. 278:12214-12221(2003) · UniProtKB (1) |
| CAMP-dependent protein kinase enhances CYP17 transcription via MKP-1 activation in H295R human adrenocortical cells. Sewer M.B., Waterman M.R. J. Biol. Chem. 278:8106-8111(2003) · Mapped (9) |
