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Parkin deficiency disrupts calcium homeostasis by modulating phospholipase C signalling.

Sandebring A., Dehvari N., Perez-Manso M., Thomas K.J., Karpilovski E., Cookson M.R., Cowburn R.F., Cedazo-Minguez A.

FEBS J. 276:5041-5052(2009) · Mapped (21)

Interleukin-18 polymorphism and physical functioning in older people: a replication study and meta-analysis.

Thomas K., Rafiq S., Frayling T.M., Ebrahim S., Kumari M., Gallacher J., Ferrucci L., Bandinelli S., Wallace R.B., Melzer D. et al.

J. Gerontol. A Biol. Sci. Med. Sci. 64:1177-1182(2009) · Mapped (4)

Examination of type 2 diabetes loci implicates CDKAL1 as a birth weight gene.

Zhao J., Li M., Bradfield J.P., Wang K., Zhang H., Sleiman P., Kim C.E., Annaiah K., Glaberson W., Glessner J.T. et al.

Diabetes 58:2414-2418(2009) · Mapped (71)

PinX1 is a novel microtubule-binding protein essential for accurate chromosome segregation.

Yuan K., Li N., Jiang K., Zhu T., Huo Y., Wang C., Lu J., Shaw A., Thomas K., Zhang J. et al.

J. Biol. Chem. 284:23072-23082(2009) · UniProtKB (1) · Mapped (4)

Mitochondrial alterations in PINK1 deficient cells are influenced by calcineurin-dependent dephosphorylation of dynamin-related protein 1.

Sandebring A., Thomas K.J., Beilina A., van der Brug M., Cleland M.M., Ahmad R., Miller D.W., Zambrano I., Cowburn R.F., Behbahani H. et al.

PLoS ONE 4:e5701-e5701(2009) · Mapped (14)

Investigation of the locus near MC4R with childhood obesity in Americans of European and African ancestry.

Grant S.F., Bradfield J.P., Zhang H., Wang K., Kim C.E., Annaiah K., Santa E., Glessner J.T., Thomas K., Garris M. et al.

Obesity (Silver Spring) 17:1461-1465(2009) · Mapped (1)

Development and validation of a TaqMan real-time reverse transcription-PCR for rapid detection of feline calicivirus.

Abd-Eldaim M.M., Wilkes R.P., Thomas K.V., Kennedy M.A.

Arch. Virol. 154:555-560(2009) · UniProtKB (9)

Pink1 forms a multiprotein complex with Miro and Milton, linking Pink1 function to mitochondrial trafficking.

Weihofen A., Thomas K.J., Ostaszewski B.L., Cookson M.R., Selkoe D.J.

Biochemistry 48:2045-2052(2009) · Mapped (1)

Evaluation of imputation-based association in and around the integrin-alpha-M (ITGAM) gene and replication of robust association between a non-synonymous functional variant within ITGAM and systemic lupus erythematosus (SLE).

Han S., Kim-Howard X., Deshmukh H., Kamatani Y., Viswanathan P., Guthridge J.M., Thomas K., Kaufman K.M., Ojwang J., Rojas-Villarraga A. et al.

Hum. Mol. Genet. 18:1171-1180(2009) · Mapped (8)

Formation of a stabilized cysteine sulfinic acid is critical for the mitochondrial function of the parkinsonism protein DJ-1.

Blackinton J., Lakshminarasimhan M., Thomas K.J., Ahmad R., Greggio E., Raza A.S., Cookson M.R., Wilson M.A.

J. Biol. Chem. 284:6476-6485(2009) · Mapped (1)

Mitochondrial function and morphology are impaired in parkin-mutant fibroblasts.

Mortiboys H., Thomas K.J., Koopman W.J., Klaffke S., Abou-Sleiman P., Olpin S., Wood N.W., Willems P.H., Smeitink J.A., Cookson M.R. et al.

Ann. Neurol. 64:555-565(2008) · Mapped (14)

Surprising up-regulation of P-selectin glycoprotein ligand-1 (PSGL-1) in endotoxin-induced uveitis.

Almulki L., Noda K., Amini R., Schering A., Garland R.C., Nakao S., Nakazawa T., Hisatomi T., Thomas K.L., Masli S. et al.

FASEB J. 23:929-939(2009) · Mapped (5)

"BRCAness" syndrome in ovarian cancer: a case-control study describing the clinical features and outcome of patients with epithelial ovarian cancer associated with BRCA1 and BRCA2 mutations.

Tan D.S., Rothermundt C., Thomas K., Bancroft E., Eeles R., Shanley S., Ardern-Jones A., Norman A., Kaye S.B., Gore M.E.

J. Clin. Oncol. 26:5530-5536(2008) · Mapped (43)

Proteolysis of proBDNF is a key regulator in the formation of memory.

Barnes P., Thomas K.L.

PLoS ONE 3:e3248-e3248(2008) · Mapped (1)

Molecular and functional characterization of the murine ldh2 promoter region: Sp-binding GC-box domains are the key cis-elements regulating ldh2 gene expression during spermatogenesis.

Chen X., Yang J., Sung D.Y., Thompson W., Walker W., Thomas K.

Mol. Cell. Endocrinol. 295:10-17(2008) · Mapped (6)

Mice deficient in the CXCR2 ligand, CXCL1 (KC/GRO-alpha), exhibit increased susceptibility to dextran sodium sulfate (DSS)-induced colitis.

Shea-Donohue T., Thomas K., Cody M.J., Aiping Zhao, Detolla L.J., Kopydlowski K.M., Fukata M., Lira S.A., Vogel S.N.

Innate Immun 14:117-124(2008) · Mapped (4)

RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways.

van der Brug M.P., Blackinton J., Chandran J., Hao L.Y., Lal A., Mazan-Mamczarz K., Martindale J., Xie C., Ahmad R., Thomas K.J. et al.

Proc. Natl. Acad. Sci. U.S.A. 105:10244-10249(2008) · Mapped (8)

Bacillus anthracis spores and lethal toxin induce IL-1beta via functionally distinct signaling pathways.

Kang T.J., Basu S., Zhang L., Thomas K.E., Vogel S.N., Baillie L., Cross A.S.

Eur. J. Immunol. 38:1574-1584(2008) · Mapped (20)

Gliadin induces an increase in intestinal permeability and zonulin release by binding to the chemokine receptor CXCR3.

Lammers K.M., Lu R., Brownley J., Lu B., Gerard C., Thomas K., Rallabhandi P., Shea-Donohue T., Tamiz A., Alkan S. et al.

Gastroenterology 135:194-204.e3(2008) · Mapped (2)

Vascular adhesion protein-1 blockade suppresses choroidal neovascularization.

Noda K., She H., Nakazawa T., Hisatomi T., Nakao S., Almulki L., Zandi S., Miyahara S., Ito Y., Thomas K.L. et al.

FASEB J. 22:2928-2935(2008) · Mapped (1)

The Dscam homologue of the crustacean Daphnia is diversified by alternative splicing like in insects.

Brites D., McTaggart S., Morris K., Anderson J., Thomas K., Colson I., Fabbro T., Little T.J., Ebert D., Du Pasquier L.

Mol. Biol. Evol. 25:1429-1439(2008) · UniProtKB (2)

The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation.

Greggio E., Zambrano I., Kaganovich A., Beilina A., Taymans J.M., Daniels V., Lewis P., Jain S., Ding J., Syed A. et al.

J. Biol. Chem. 283:16906-16914(2008) · Mapped (4)

The netrin receptor UNC5B promotes angiogenesis in specific vascular beds.

Navankasattusas S., Whitehead K.J., Suli A., Sorensen L.K., Lim A.H., Zhao J., Park K.W., Wythe J.D., Thomas K.R., Chien C.B. et al.

Development 135:659-667(2008) · Mapped (13)

Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP.

Haque M.E., Thomas K.J., D'Souza C., Callaghan S., Kitada T., Slack R.S., Fraser P., Cookson M.R., Tandon A., Park D.S.

Proc. Natl. Acad. Sci. U.S.A. 105:1716-1721(2008) · Mapped (6)

Prohibitin silencing reverses stabilization of mitochondrial integrity and chemoresistance in ovarian cancer cells by increasing their sensitivity to apoptosis.

Gregory-Bass R.C., Olatinwo M., Xu W., Matthews R., Stiles J.K., Thomas K., Liu D., Tsang B., Thompson W.E.

Int. J. Cancer 122:1923-1930(2008) · Mapped (7)

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