| Attenuation of T cell receptor signaling by serine phosphorylation-mediated lysine 30 ubiquitination of SLP-76 protein. Wang X., Li J.P., Chiu L.L., Lan J.L., Chen D.Y., Boomer J., Tan T.H.
J. Biol. Chem. 287:34091-34100(2012) · Mapped (6) |
| TBK1-associated protein in endolysosomes (TAPE)/CC2D1A is a key regulator linking RIG-I-like receptors to antiviral immunity. Chen K.R., Chang C.H., Huang C.Y., Lin C.Y., Lin W.Y., Lo Y.C., Yang C.Y., Hsing E.W., Chen L.F., Shih S.R. et al.
J. Biol. Chem. 287:32216-32221(2012) · Mapped (7) |
| Rare and novel epidermal growth factor receptor mutations in non-small-cell lung cancer and lack of clinical response to gefitinib in two cases. Sharma A., Tan T.H., Cheetham G., Scott H.S., Brown M.P.
J Thorac Oncol 7:941-942(2012) · Mapped (19) |
| DUSP4 deficiency enhances CD25 expression and CD4+ T-cell proliferation without impeding T-cell development. Huang C.Y., Lin Y.C., Hsiao W.Y., Liao F.H., Huang P.Y., Tan T.H.
Eur. J. Immunol. 42:476-488(2012) · Mapped (4) |
| The kinase GLK controls autoimmunity and NF-kappaB signaling by activating the kinase PKC-theta in T cells. Chuang H.C., Lan J.L., Chen D.Y., Yang C.Y., Chen Y.M., Li J.P., Huang C.Y., Liu P.E., Wang X., Tan T.H.
Nat. Immunol. 12:1113-1118(2011) · Mapped (16) |
| JNK pathway-associated phosphatase dephosphorylates focal adhesion kinase and suppresses cell migration. Li J.P., Fu Y.N., Chen Y.R., Tan T.H.
J. Biol. Chem. 285:5472-5478(2010) · Mapped (9) |
| Proteasome-mediated degradation and functions of hematopoietic progenitor kinase 1 in pancreatic cancer. Wang H., Song X., Logsdon C., Zhou G., Evans D.B., Abbruzzese J.L., Hamilton S.R., Tan T.H., Wang H.
Cancer Res. 69:1063-1070(2009) · Mapped (2) |
| Expression of MAP4K4 is associated with worse prognosis in patients with stage II pancreatic ductal adenocarcinoma. Liang J.J., Wang H., Rashid A., Tan T.H., Hwang R.F., Hamilton S.R., Abbruzzese J.L., Evans D.B., Wang H.
Clin. Cancer Res. 14:7043-7049(2008) · Mapped (10) |
| Actin-binding protein 1 regulates B cell receptor-mediated antigen processing and presentation in response to B cell receptor activation. Onabajo O.O., Seeley M.K., Kale A., Qualmann B., Kessels M., Han J., Tan T.H., Song W.
J. Immunol. 180:6685-6695(2008) · Mapped (1) |
| Caspase-9-induced mitochondrial disruption through cleavage of anti-apoptotic BCL-2 family members. Chen M., Guerrero A.D., Huang L., Shabier Z., Pan M., Tan T.H., Wang J.
J. Biol. Chem. 282:33888-33895(2007) · Mapped (17) |
| Induction of apoptosis by the severe acute respiratory syndrome coronavirus 7a protein is dependent on its interaction with the Bcl-XL protein. Tan Y.X., Tan T.H., Lee M.J., Tham P.Y., Gunalan V., Druce J., Birch C., Catton M., Fu N.Y., Yu V.C. et al.
J. Virol. 81:6346-6355(2007) · Mapped (4) |
| Hematopoietic progenitor kinase 1 negatively regulates T cell receptor signaling and T cell-mediated immune responses. Shui J.W., Boomer J.S., Han J., Xu J., Dement G.A., Zhou G., Tan T.H.
Nat. Immunol. 8:84-91(2007) · Mapped (3) |
| Conditional knockout mice reveal an essential role of protein phosphatase 4 in thymocyte development and pre-T-cell receptor signaling. Shui J.W., Hu M.C., Tan T.H.
Mol. Cell. Biol. 27:79-91(2007) · Mapped (2) |
| Severe acute respiratory syndrome coronavirus protein 7a interacts with hSGT. Fielding B.C., Gunalan V., Tan T.H.P., Chou C.-F., Shen S., Khan S., Lim S.G., Hong W., Tan Y.-J.
Biochem. Biophys. Res. Commun. 343:1201-1208(2006) · UniProtKB (5) |
| Tumorigenesis suppressor Pdcd4 down-regulates mitogen-activated protein kinase kinase kinase kinase 1 expression to suppress colon carcinoma cell invasion. Yang H.-S., Matthews C.P., Clair T., Wang Q., Baker A.R., Li C.-C., Tan T.-H., Colburn N.H.
Mol. Cell. Biol. 26:1297-1306(2006) · UniProtKB (1) · Mapped (4) |
| HIP-55 is important for T-cell proliferation, cytokine production, and immune responses. Han J., Shui J.W., Zhang X., Zheng B., Han S., Tan T.H.
Mol. Cell. Biol. 25:6869-6878(2005) · Mapped (11) |
| The severe acute respiratory syndrome coronavirus 3a protein up-regulates expression of fibrinogen in lung epithelial cells. Tan Y.J., Tham P.Y., Chan D.Z., Chou C.-F., Shen S., Fielding B.C., Tan T.H., Lim S.G., Hong W.
J. Virol. 79:10083-10087(2005) · UniProtKB (1) |
| Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine/threonine phosphatase 4. Zhang X., Ozawa Y., Lee H., Wen Y.D., Tan T.H., Wadzinski B.E., Seto E.
Genes Dev. 19:827-839(2005) · UniProtKB (2) |
| Overexpression of 7a, a protein specifically encoded by the severe acute respiratory syndrome coronavirus, induces apoptosis via a caspase-dependent pathway. Tan Y.-J., Fielding B.C., Goh P.-Y., Shen S., Tan T.H.P., Lim S.G., Hong W.
J. Virol. 78:14043-14047(2004) · UniProtKB (1) · Mapped (3) |
| Protein phosphatase 4 is a positive regulator of hematopoietic progenitor kinase 1. Zhou G., Boomer J.S., Tan T.H.
J. Biol. Chem. 279:49551-49561(2004) · Mapped (2) |
| Protein phosphatase 4 interacts with and down-regulates insulin receptor substrate 4 following tumor necrosis factor-alpha stimulation. Mihindukulasuriya K.A., Zhou G., Qin J., Tan T.-H.
J. Biol. Chem. 279:46588-46594(2004) · UniProtKB (2) · Mapped (6) |
| Inhibition of JNK2 disrupts anaphase and produces aneuploidy in mammalian cells. MacCorkle R.A., Tan T.H.
J. Biol. Chem. 279:40112-40121(2004) · Mapped (6) |
| Characterization of a unique group-specific protein (U122) of the severe acute respiratory syndrome coronavirus. Fielding B.C., Tan Y.-J., Shuo S., Tan T.H.P., Ooi E.-E., Lim S.G., Hong W., Goh P.-Y.
J. Virol. 78:7311-7318(2004) · UniProtKB (1) |
| A novel severe acute respiratory syndrome coronavirus protein, U274, is transported to the cell surface and undergoes endocytosis. Tan Y.-J., Teng E., Shen S., Tan T.H.P., Goh P.-Y., Fielding B.C., Ooi E.-E., Tan H.-C., Lim S.G., Hong W.
J. Virol. 78:6723-6734(2004) · UniProtKB (5) |
| The SH3 domain-containing adaptor HIP-55 mediates c-Jun N-terminal kinase activation in T cell receptor signaling. Han J., Kori R., Shui J.W., Chen Y.R., Yao Z., Tan T.H.
J. Biol. Chem. 278:52195-52202(2003) · Mapped (14) |
