| Genetic characterization and susceptibility for sarcoidosis in Japanese patients: risk factors of BTNL2 gene polymorphisms and HLA class II alleles. Suzuki H., Ota M., Meguro A., Katsuyama Y., Kawagoe T., Ishihara M., Asukata Y., Takeuchi M., Ito N., Shibuya E. et al.
Invest. Ophthalmol. Vis. Sci. 53:7109-7115(2012) · Mapped (306) |
| Discovery and preclinical profile of teneligliptin (3-[(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl]thiazolidine): a highly potent, selective, long-lasting and orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. Yoshida T., Akahoshi F., Sakashita H., Kitajima H., Nakamura M., Sonda S., Takeuchi M., Tanaka Y., Ueda N., Sekiguchi S. et al.
Bioorg. Med. Chem. 20:5705-5719(2012) · Mapped (1) |
| Fused bicyclic heteroarylpiperazine-substituted L-prolylthiazolidines as highly potent DPP-4 inhibitors lacking the electrophilic nitrile group. Yoshida T., Akahoshi F., Sakashita H., Sonda S., Takeuchi M., Tanaka Y., Nabeno M., Kishida H., Miyaguchi I., Hayashi Y.
Bioorg. Med. Chem. 20:5033-5041(2012) · Mapped (1) |
| Common variants in the COL4A4 gene confer susceptibility to lattice degeneration of the retina. Meguro A., Ideta H., Ota M., Ito N., Ideta R., Yonemoto J., Takeuchi M., Uemoto R., Nishide T., Iijima Y. et al.
PLoS ONE 7:e39300-e39300(2012) · Mapped (2) |
| Adiponectin is inversely associated with ratio of serum levels of AGEs to sRAGE and vascular inflammation. Tahara N., Yamagishi S., Tahara A., Ishibashi M., Hayabuchi N., Takeuchi M., Imaizumi T.
Int. J. Cardiol. 158:461-462(2012) · Mapped (39) |
| Glycer-AGEs-RAGE signaling enhances the angiogenic potential of hepatocellular carcinoma by upregulating VEGF expression. Takino J., Yamagishi S., Takeuchi M.
World J. Gastroenterol. 18:1781-1788(2012) · Mapped (7) |
| Interleukin enhancer-binding factor 3/NF110 is a target of YM155, a suppressant of survivin. Nakamura N., Yamauchi T., Hiramoto M., Yuri M., Naito M., Takeuchi M., Yamanaka K., Kita A., Nakahara T., Kinoyama I. et al.
Mol. Cell Proteomics 11:M111.013243-M111.013243(2012) · Mapped (10) |
| Structural basis for telmisartan-mediated partial activation of PPAR gamma. Amano Y., Yamaguchi T., Ohno K., Niimi T., Orita M., Sakashita H., Takeuchi M.
Hypertens. Res. 35:715-719(2012) · Mapped (2) |
| Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human. Ichimura A., Hirasawa A., Poulain-Godefroy O., Bonnefond A., Hara T., Yengo L., Kimura I., Leloire A., Liu N., Iida K. et al.
Nature 483:350-354(2012) · UniProtKB (2) · Mapped (2) |
| The NMR structure of stomagen reveals the basis of stomatal density regulation by plant peptide hormones. Ohki S., Takeuchi M., Mori M.
Nat Commun 2:512-512(2011) · Mapped (1) |
| Pdx1 and Ngn3 overexpression enhances pancreatic differentiation of mouse ES cell-derived endoderm population. Kubo A., Stull R., Takeuchi M., Bonham K., Gouon-Evans V., Sho M., Iwano M., Saito Y., Keller G., Snodgrass R.
PLoS ONE 6:e24058-e24058(2011) · Mapped (3) |
| Rac1 GTPase in rodent kidneys is essential for salt-sensitive hypertension via a mineralocorticoid receptor-dependent pathway. Shibata S., Mu S., Kawarazaki H., Muraoka K., Ishizawa K., Yoshida S., Kawarazaki W., Takeuchi M., Ayuzawa N., Miyoshi J. et al.
J. Clin. Invest. 121:3233-3243(2011) · Mapped (7) |
| Antitumor activity of YM155, a selective small-molecule survivin suppressant, alone and in combination with docetaxel in human malignant melanoma models. Yamanaka K., Nakahara T., Yamauchi T., Kita A., Takeuchi M., Kiyonaga F., Kaneko N., Sasamata M.
Clin. Cancer Res. 17:5423-5431(2011) · Mapped (9) |
| Increases of vitreous monocyte chemotactic protein 1 and interleukin 8 levels in patients with concurrent hypertension and diabetic retinopathy. Wakabayashi Y., Usui Y., Okunuki Y., Kezuka T., Takeuchi M., Iwasaki T., Ohno A., Goto H.
Retina (Philadelphia, Pa.) 31:1951-1957(2011) · Mapped (4) |
| Syntaxin 1B suppresses macropinocytosis and semaphorin 3A-induced growth cone collapse. Kabayama H., Takeuchi M., Taniguchi M., Tokushige N., Kozaki S., Mizutani A., Nakamura T., Mikoshiba K.
J. Neurosci. 31:7357-7364(2011) · UniProtKB (1) |
| Bmi1 is essential for leukemic reprogramming of myeloid progenitor cells. Yuan J., Takeuchi M., Negishi M., Oguro H., Ichikawa H., Iwama A.
Leukemia 25:1335-1343(2011) · Mapped (7) |
| Activation of receptor for advanced glycation end products induces osteogenic differentiation of vascular smooth muscle cells. Suga T., Iso T., Shimizu T., Tanaka T., Yamagishi S., Takeuchi M., Imaizumi T., Kurabayashi M.
J. Atheroscler. Thromb. 18:670-683(2011) · Mapped (47) |
| Calcium channel blocker inhibition of AGE and RAGE axis limits renal injury in nondiabetic patients with stage I or II chronic kidney disease. Nakamura T., Sato E., Fujiwara N., Kawagoe Y., Koide H., Ueda Y., Takeuchi M., Yamagishi S.
Clin Cardiol 34:372-377(2011) · Mapped (36) |
| miR-155, a Modulator of FOXO3a Protein Expression, Is Underexpressed and Cannot Be Upregulated by Stimulation of HOZOT, a Line of Multifunctional Treg. Yamamoto M., Kondo E., Takeuchi M., Harashima A., Otani T., Tsuji-Takayama K., Yamasaki F., Kumon H., Kibata M., Nakamura S.
PLoS ONE 6:e16841-e16841(2011) · Mapped (4) |
| Advanced glycation end products increase permeability of brain microvascular endothelial cells through reactive oxygen species-induced vascular endothelial growth factor expression. Niiya Y., Abumiya T., Yamagishi S., Takino J., Takeuchi M.
J Stroke Cerebrovasc Dis 21:293-298(2012) · Mapped (6) |
| Irbesartan inhibits advanced glycation end product (AGE)-induced up-regulation of vascular cell adhesion molecule-1 (VCAM-1) mRNA levels in glomerular endothelial cells. Matsui T., Nishino Y., Maeda S., Takeuchi M., Yamagishi S.
Microvasc. Res. 81:269-273(2011) · Mapped (3) |
| A novel ER J-protein DNAJB12 accelerates ER-associated degradation of membrane proteins including CFTR. Yamamoto Y.H., Kimura T., Momohara S., Takeuchi M., Tani T., Kimata Y., Kadokura H., Kohno K.
Cell Struct. Funct. 35:107-116(2010) · Mapped (3) |
| Pigment epithelium-derived factor (PEDF) inhibits proximal tubular cell injury in early diabetic nephropathy by suppressing advanced glycation end products (AGEs)-receptor (RAGE) axis. Maeda S., Matsui T., Takeuchi M., Yoshida Y., Yamakawa R., Fukami K., Yamagishi S.
Pharmacol. Res. 63:241-248(2011) · Mapped (36) |
| MK615 decreases RAGE expression and inhibits TAGE-induced proliferation in hepatocellular carcinoma cells. Sakuraoka Y., Sawada T., Okada T., Shiraki T., Miura Y., Hiraishi K., Ohsawa T., Adachi M., Takino J., Takeuchi M. et al.
World J. Gastroenterol. 16:5334-5341(2010) · Mapped (36) |
| Ethnic difference in patients with type 2 diabetes mellitus in inter-East Asian populations: a systematic review and meta-analysis focusing on gene polymorphism. Takeuchi M., Okamoto K., Takagi T., Ishii H.
J Diabetes 1:255-262(2009) · Mapped (43) |
