| Sensing of commensal organisms by the intracellular sensor NOD1 mediates experimental pancreatitis. Tsuji Y., Watanabe T., Kudo M., Arai H., Strober W., Chiba T.
Immunity 37:326-338(2012) · Mapped (16) |
| Critical role for mast cells in interleukin-1beta-driven skin inflammation associated with an activating mutation in the nlrp3 protein. Nakamura Y., Franchi L., Kambe N., Meng G., Strober W., Nunez G.
Immunity 37:85-95(2012) · Mapped (13) |
| MCAM-expressing CD4(+) T cells in peripheral blood secrete IL-17A and are significantly elevated in inflammatory autoimmune diseases. Dagur P.K., Biancotto A., Wei L., Sen H.N., Yao M., Strober W., Nussenblatt R.B., McCoy J.P. Jr.
J. Autoimmun. 37:319-327(2011) · Mapped (5) |
| Tumor development in murine ulcerative colitis depends on MyD88 signaling of colonic F4/80+CD11b(high)Gr1(low) macrophages. Schiechl G., Bauer B., Fuss I., Lang S.A., Moser C., Ruemmele P., Rose-John S., Neurath M.F., Geissler E.K., Schlitt H.J. et al.
J. Clin. Invest. 121:1692-1708(2011) · Mapped (20) |
| A polymorphism in the coding region of Il12b promotes IL-12p70 and IL-23 heterodimer formation. Zwiers A., Fuss I.J., Seegers D., Konijn T., Garcia-Vallejo J.J., Samsom J.N., Strober W., Kraal G., Bouma G.
J. Immunol. 186:3572-3580(2011) · Mapped (5) |
| The TNF-family cytokine TL1A drives IL-13-dependent small intestinal inflammation. Meylan F., Song Y.J., Fuss I., Villarreal S., Kahle E., Malm I.J., Acharya K., Ramos H.L., Lo L., Mentink-Kane M.M. et al.
Mucosal Immunol 4:172-185(2011) · Mapped (4) |
| Positive and negative transcriptional regulation of the Foxp3 gene is mediated by access and binding of the Smad3 protein to enhancer I. Xu L., Kitani A., Stuelten C., McGrady G., Fuss I., Strober W.
Immunity 33:313-325(2010) · Mapped (17) |
| Molecular mechanisms regulating TGF-beta-induced Foxp3 expression. Xu L., Kitani A., Strober W.
Mucosal Immunol 3:230-238(2010) · Mapped (5) |
| NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway. Watanabe T., Asano N., Fichtner-Feigl S., Gorelick P.L., Tsuji Y., Matsumoto Y., Chiba T., Fuss I.J., Kitani A., Strober W.
J. Clin. Invest. 120:1645-1662(2010) · Mapped (32) |
| New insights into the nature of autoinflammatory diseases from mice with Nlrp3 mutations. Meng G., Strober W.
Eur. J. Immunol. 40:649-653(2010) · Mapped (2) |
| A mutation in the Nlrp3 gene causing inflammasome hyperactivation potentiates Th17 cell-dominant immune responses. Meng G., Zhang F., Fuss I., Kitani A., Strober W.
Immunity 30:860-874(2009) · Mapped (6) |
| The molecular basis of NOD2 susceptibility mutations in Crohn's disease. Strober W., Kitani A., Fuss I., Asano N., Watanabe T.
Mucosal Immunol 1 Suppl 1:S5-9(2008) · Mapped (8) |
| IL-13 signaling via IL-13R alpha2 induces major downstream fibrogenic factors mediating fibrosis in chronic TNBS colitis. Fichtner-Feigl S., Young C.A., Kitani A., Geissler E.K., Schlitt H.J., Strober W.
Gastroenterology 135:2003-13, 2008:2013.e1-7(2008) · Mapped (14) |
| Interactions among the transcription factors Runx1, RORgammat and Foxp3 regulate the differentiation of interleukin 17-producing T cells. Zhang F., Meng G., Strober W.
Nat. Immunol. 9:1297-1306(2008) · Mapped (10) |
| A transient breach in the epithelial barrier leads to regulatory T-cell generation and resistance to experimental colitis. Boirivant M., Amendola A., Butera A., Sanchez M., Xu L., Marinaro M., Kitani A., Di Giacinto C., Strober W., Fuss I.J.
Gastroenterology 135:1612-1623.e5(2008) · Mapped (4) |
| T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance. Pesu M., Watford W.T., Wei L., Xu L., Fuss I., Strober W., Andersson J., Shevach E.M., Quezado M., Bouladoux N. et al.
Nature 455:246-250(2008) · Mapped (4) |
| Notch1 signaling and regulatory T cell function. Asano N., Watanabe T., Kitani A., Fuss I.J., Strober W.
J. Immunol. 180:2796-2804(2008) · Mapped (10) |
| Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis. Watanabe T., Asano N., Murray P.J., Ozato K., Tailor P., Fuss I.J., Kitani A., Strober W.
J. Clin. Invest. 118:545-559(2008) · Mapped (10) |
| NOD2 transgenic mice exhibit enhanced MDP-mediated down-regulation of TLR2 responses and resistance to colitis induction. Yang Z., Fuss I.J., Watanabe T., Asano N., Davey M.P., Rosenbaum J.T., Strober W., Kitani A.
Gastroenterology 133:1510-1521(2007) · Mapped (27) |
| Cutting edge: regulatory T cells induce CD4+CD25-Foxp3- T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-beta. Xu L., Kitani A., Fuss I., Strober W.
J. Immunol. 178:6725-6729(2007) · Mapped (4) |
| Nucleotide binding oligomerization domain 2 deficiency leads to dysregulated TLR2 signaling and induction of antigen-specific colitis. Watanabe T., Kitani A., Murray P.J., Wakatsuki Y., Fuss I.J., Strober W.
Immunity 25:473-485(2006) · Mapped (29) |
| T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNG gene acetylation and transcription. Usui T., Preiss J.C., Kanno Y., Yao Z.J., Bream J.H., O'Shea J.J., Strober W.
J. Exp. Med. 203:755-766(2006) · Mapped (9) |
| Signalling pathways and molecular interactions of NOD1 and NOD2. Strober W., Murray P.J., Kitani A., Watanabe T.
Nat. Rev. Immunol. 6:9-20(2006) · Mapped (13) |
| IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis. Fichtner-Feigl S., Strober W., Kawakami K., Puri R.K., Kitani A.
Nat. Med. 12:99-106(2006) · Mapped (17) |
| A major quantitative trait locus on mouse chromosome 3 is involved in disease susceptibility in different colitis models. Borm M.E., He J., Kelsall B., Pena A.S., Strober W., Bouma G.
Gastroenterology 128:74-85(2005) · Mapped (11) |
