| Toxicity modelling of Plk1-targeted therapies in genetically engineered mice and cultured primary mammalian cells. Raab M., Kappel S., Kramer A., Sanhaji M., Matthess Y., Kurunci-Csacsko E., Calzada-Wack J., Rathkolb B., Rozman J., Adler T. et al.
Nat Commun 2:395-395(2011) · Mapped (4) |
| SKAP1 protein PH domain determines RapL membrane localization and Rap1 protein complex formation for T cell receptor (TCR) activation of LFA-1. Raab M., Smith X., Matthess Y., Strebhardt K., Rudd C.E.
J. Biol. Chem. 286:29663-29670(2011) · Mapped (7) |
| Cdk1/cyclin B1 controls Fas-mediated apoptosis by regulating caspase-8 activity. Matthess Y., Raab M., Sanhaji M., Lavrik I.N., Strebhardt K.
Mol. Cell. Biol. 30:5726-5740(2010) · UniProtKB (2) · Mapped (9) |
| Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy. Strebhardt K.
Nat. Rev. Drug Discov. 9:643-660(2010) · UniProtKB (3) |
| Restoration of the tumor suppressor p53 by downregulating cyclin B1 in human papillomavirus 16/18-infected cancer cells. Kreis N.N., Sanhaji M., Kramer A., Sommer K., Rodel F., Strebhardt K., Yuan J.
Oncogene 29:5591-5603(2010) · Mapped (41) |
| Functional and spatial regulation of mitotic centromere-associated kinesin by cyclin-dependent kinase 1. Sanhaji M., Friel C.T., Kreis N.N., Kramer A., Martin C., Howard J., Strebhardt K., Yuan J.
Mol. Cell. Biol. 30:2594-2607(2010) · Mapped (8) |
| T cell receptor "inside-out" pathway via signaling module SKAP1-RapL regulates T cell motility and interactions in lymph nodes. Raab M., Wang H., Lu Y., Smith X., Wu Z., Strebhardt K., Ladbury J.E., Rudd C.E.
Immunity 32:541-556(2010) · Mapped (10) |
| Adaptor SKAP-55 binds p21 activating exchange factor RasGRP1 and negatively regulates the p21-ERK pathway in T-cells. Schneider H., Wang H., Raab M., Valk E., Smith X., Lovatt M., Wu Z., Maqueira-Iglesias B., Strebhardt K., Rudd C.E.
PLoS ONE 3:e1718-e1718(2008) · Mapped (8) |
| Investigations on the inducible and endothelial nitric oxide synthases in human breast cancer cell line MCF-7 - estrogen has an influence on e-NOS, but not on i-NOS. Loibl S., Bratengeier J., Farines V., von Minckwitz G., Spankuch B., Schini-Kerth V., Nepveu F., Strebhardt K., Kaufmann M.
Pathol. Res. Pract. 202:1-7(2006) · Mapped (7) |
| STAT 3 activation in head and neck squamous cell carcinomas is controlled by the EGFR. Hambek M., Baghi M., Strebhardt K., Strebhard K., May A., Adunka O., Gstottner W., Knecht R.
Anticancer Res. 24:3881-3886(2004) · Mapped (26) |
| Inhibition of integrin-mediated cell adhesion but not directional cell migration requires catalytic activity of EphB3 receptor tyrosine kinase. Role of Rho family small GTPases. Miao H., Strebhardt K., Pasquale E.B., Shen T.L., Guan J.L., Wang B.
J. Biol. Chem. 280:923-932(2005) · UniProtKB (1) · Mapped (1) |
| Cooperative phosphorylation including the activity of polo-like kinase 1 regulates the subcellular localization of cyclin B1. Yuan J., Eckerdt F., Bereiter-Hahn J., Kurunci-Csacsko E., Kaufmann M., Strebhardt K.
Oncogene 21:8282-8292(2002) · UniProtKB (2) · Mapped (8) |
| Adhesion induced expression of the serine/threonine kinase Fnk in human macrophages. Holtrich U., Wolf G., Yuan J., Bereiter-Hahn J., Karn T., Weiler M., Kauselmann G., Rehli M., Andreesen R., Kaufmann M. et al.
Oncogene 19:4832-4839(2000) · UniProtKB (2) |
| Identification and functional characterization of the human and murine fibroblast growth factor receptor 4 promoters. Becker M., Brauninger A., Wolf G., Kaufmann M., Strebhardt K.
Biochem. Biophys. Res. Commun. 276:493-501(2000) · Mapped (3) |
| The polo-like protein kinases Fnk and Snk associate with a Ca(2+)- and integrin-binding protein and are regulated dynamically with synaptic plasticity. Kauselmann G., Weiler M., Wulff P., Jessberger S., Konietzko U., Scafidi J., Staubli U., Bereiter-Hahn J., Strebhardt K., Kuhl D.
EMBO J. 18:5528-5539(1999) · UniProtKB (3) · Mapped (2) |
| PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor. Hock B., Bohme B., Karn T., Yamamoto T., Kaibuchi K., Holtrich U., Holland S., Pawson T., Rubsamen-Waigmann H., Strebhardt K.
Proc. Natl. Acad. Sci. U.S.A. 95:9779-9784(1998) · Mapped (8) |
| Tyrosine-614, the major autophosphorylation site of the receptor tyrosine kinase HEK2, functions as multi-docking site for SH2-domain mediated interactions. Hock B., Boehme B., Karn T., Feller S., Ruebsamen-Waigmann H., Strebhardt K.
Oncogene 17:255-260(1998) · UniProtKB (1) |
| Cell-cell adhesion mediated by binding of membrane-anchored ligand LERK-2 to the EPH-related receptor human embryonal kinase 2 promotes tyrosine kinase activity. Bohme B., VandenBos T., Cerretti D.P., Park L.S., Holtrich U., Rubsamen-Waigmann H., Strebhardt K.
J. Biol. Chem. 271:24747-24752(1996) |
| Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis. Gale N.W., Holland S.J., Valenzuela D.M., Flenniken A., Pan L., Ryan T.E., Henkemeyer M., Strebhardt K., Hirai H., Wilkinson D.G. et al.
Neuron 17:9-19(1996) · Mapped (12) |
| PCR mediated detection of a new human receptor-tyrosine-kinase, HEK 2. Boehme B., Holtrich U., Wolf G., Luzius H., Grzeschik K.-H., Strebhardt K., Ruebsamen-Waigmann H.
Oncogene 8:2857-2862(1993) · UniProtKB (1) |
| Structure, expression and chromosomal mapping of TKT from man and mouse: a new subclass of receptor tyrosine kinases with a factor VIII-like domain. Karn T., Holtrich U., Braeuninger A., Boehme B., Wolf G., Ruebsamen-Waigmann H., Strebhardt K.
Oncogene 8:3433-3440(1993) · UniProtKB (2) · Mapped (1) |
| Induction and down-regulation of PLK, a human serine/threonine kinase expressed in proliferating cells and tumors. Holtrich U., Wolf G., Braeuninger A., Karn T., Boehme B., Ruebsamen-Waigmann H., Strebhardt K.
Proc. Natl. Acad. Sci. U.S.A. 91:1736-1740(1994) · UniProtKB (1) |
| Characterization of the human CSK locus. Braeuninger A., Karn T., Strebhardt K., Ruebsamen-Waigmann H.
Oncogene 8:1365-1369(1993) · UniProtKB (1) |
| Identification and functional characterization of the human and murine polo-like kinase (Plk) promoter. Brauninger A., Strebhardt K., Rubsamen-Waigmann H.
Oncogene 11:1793-1800(1995) · UniProtKB (1) · Mapped (3) |
| Additional member of the protein-tyrosine kinase family: the src- and lck-related protooncogene c-tkl. Strebhardt K., Mullins J.I., Bruck C., Ruebsamen-Waigmann H.
Proc. Natl. Acad. Sci. U.S.A. 84:8778-8782(1987) · UniProtKB (1) |
