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Structural analysis of a monomeric form of the twin-arginine leader peptide binding chaperone Escherichia coli DmsD.

Stevens C.M., Winstone T.M., Turner R.J., Paetzel M.

J. Mol. Biol. 389:124-133(2009) · Mapped (1)

Granulocyte/macrophage-colony-stimulating factor autoantibodies and myeloid cell immune functions in healthy subjects.

Uchida K., Nakata K., Suzuki T., Luisetti M., Watanabe M., Koch D.E., Stevens C.A., Beck D.C., Denson L.A., Carey B.C. et al.

Blood 113:2547-2556(2009) · Mapped (2)

LKB1/KRAS mutant lung cancers constitute a genetic subset of NSCLC with increased sensitivity to MAPK and mTOR signalling inhibition.

Mahoney C.L., Choudhury B., Davies H., Edkins S., Greenman C., Haaften G., Mironenko T., Santarius T., Stevens C., Stratton M.R. et al.

Br. J. Cancer 100:370-375(2009) · Mapped (6)

Peptide combinatorial libraries identify TSC2 as a death-associated protein kinase (DAPK) death domain-binding protein and reveal a stimulatory role for DAPK in mTORC1 signaling.

Stevens C., Lin Y., Harrison B., Burch L., Ridgway R.A., Sansom O., Hupp T.

J. Biol. Chem. 284:334-344(2009) · Mapped (28)

Familial pulmonary alveolar proteinosis caused by mutations in CSF2RA.

Suzuki T., Sakagami T., Rubin B.K., Nogee L.M., Wood R.E., Zimmerman S.L., Smolarek T., Dishop M.K., Wert S.E., Whitsett J.A. et al.

J. Exp. Med. 205:2703-2710(2008) · UniProtKB (1) · Mapped (3)

ATP stimulates MDM2-mediated inhibition of the DNA-binding function of E2F1.

Stevens C., Pettersson S., Wawrzynow B., Wallace M., Ball K., Zylicz A., Hupp T.R.

FEBS J. 275:4875-4886(2008) · Mapped (26)

X-linked protocadherin 19 mutations cause female-limited epilepsy and cognitive impairment.

Dibbens L.M., Tarpey P.S., Hynes K., Bayly M.A., Scheffer I.E., Smith R., Bomar J., Sutton E., Vandeleur L., Shoubridge C. et al.

Nat. Genet. 40:776-781(2008) · UniProtKB (1) · Mapped (1)

An alternative transcript from the death-associated protein kinase 1 locus encoding a small protein selectively mediates membrane blebbing.

Lin Y., Stevens C., Hrstka R., Harrison B., Fourtouna A., Pathuri S., Vojtesek B., Hupp T.

FEBS J. 275:2574-2584(2008) · Mapped (8)

Env length and N-linked glycosylation following transmission of human immunodeficiency virus Type 1 subtype B viruses.

Liu Y., Curlin M.E., Diem K., Zhao H., Ghosh A.K., Zhu H., Woodward A.S., Maenza J., Stevens C.E., Stekler J. et al.

Virology 374:229-233(2008) · UniProtKB (237)

DAPK-1 binding to a linear peptide motif in MAP1B stimulates autophagy and membrane blebbing.

Harrison B., Kraus M., Burch L., Stevens C., Craig A., Gordon-Weeks P., Hupp T.R.

J. Biol. Chem. 283:9999-10014(2008) · Mapped (18)

Identification of two independent risk factors for lupus within the MHC in United Kingdom families.

Fernando M.M., Stevens C.R., Sabeti P.C., Walsh E.C., McWhinnie A.J., Shah A., Green T., Rioux J.D., Vyse T.J.

PLoS Genet. 3:e192-e192(2007) · Mapped (903)

Association between polymorphisms in HSD3B1 and UGT2B17 and prostate cancer risk.

Park J.Y., Tanner J.P., Sellers T.A., Huang Y., Stevens C.K., Dossett N., Shankar R.A., Zachariah B., Heysek R., Pow-Sang J.

Urology 70:374-379(2007) · Mapped (2)

Mutations in UPF3B, a member of the nonsense-mediated mRNA decay complex, cause syndromic and nonsyndromic mental retardation.

Tarpey P.S., Raymond F.L., Nguyen L.S., Rodriguez J., Hackett A., Vandeleur L., Smith R., Shoubridge C., Edkins S., Stevens C. et al.

Nat. Genet. 39:1127-1133(2007) · UniProtKB (1) · Mapped (2)

Mutations in the BRWD3 gene cause X-linked mental retardation associated with macrocephaly.

Field M., Tarpey P.S., Smith R., Edkins S., O'Meara S., Stevens C., Tofts C., Teague J., Butler A., Dicks E. et al.

Am. J. Hum. Genet. 81:367-374(2007) · UniProtKB (1)

Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers.

Maser R.S., Choudhury B., Campbell P.J., Feng B., Wong K.K., Protopopov A., O'Neil J., Gutierrez A., Ivanova E., Perna I. et al.

Nature 447:966-971(2007) · Mapped (14)

Cloning and bioinformatics of amphibian mu, delta, kappa, and nociceptin opioid receptors expressed in brain tissue: evidence for opioid receptor divergence in mammals.

Stevens C.W., Brasel C.M., Mohan S.

Neurosci. Lett. 419:189-194(2007) · UniProtKB (4)

Patterns of somatic mutation in human cancer genomes.

Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C. et al.

Nature 446:153-158(2007) · UniProtKB (453)

Identification of a dominant negative functional domain on DAPK-1 that degrades DAPK-1 protein and stimulates TNFR-1-mediated apoptosis.

Lin Y., Stevens C., Hupp T.

J. Biol. Chem. 282:16792-16802(2007) · Mapped (10)

A germ line mutation in the death domain of DAPK-1 inactivates ERK-induced apoptosis.

Stevens C., Lin Y., Sanchez M., Amin E., Copson E., White H., Durston V., Eccles D.M., Hupp T.

J. Biol. Chem. 282:13791-13803(2007) · Mapped (8)

Mutations in CUL4B, which encodes a ubiquitin E3 ligase subunit, cause an X-linked mental retardation syndrome associated with aggressive outbursts, seizures, relative macrocephaly, central obesity, hypogonadism, pes cavus, and tremor.

Tarpey P.S., Raymond F.L., O'Meara S., Edkins S., Teague J., Butler A., Dicks E., Stevens C., Tofts C., Avis T. et al.

Am. J. Hum. Genet. 80:345-352(2007) · UniProtKB (1) · Mapped (2)

Mutations in the gene encoding the sigma 2 subunit of the adaptor protein 1 complex, AP1S2, cause X-linked mental retardation.

Tarpey P.S., Stevens C., Teague J., Edkins S., O'Meara S., Avis T., Barthorpe S., Buck G., Butler A., Cole J. et al.

Am. J. Hum. Genet. 79:1119-1124(2006) · UniProtKB (1)

Mutations in FRMD7, a newly identified member of the FERM family, cause X-linked idiopathic congenital nystagmus.

Tarpey P., Thomas S., Sarvananthan N., Mallya U., Lisgo S., Talbot C.J., Roberts E.O., Awan M., Surendran M., McLean R.J. et al.

Nat. Genet. 38:1242-1244(2006) · UniProtKB (1) · Mapped (1)

Selection on the human immunodeficiency virus type 1 proteome following primary infection.

Liu Y., McNevin J., Cao J., Zhao H., Genowati I., Wong K., McLaughlin S., McSweyn M.D., Diem K., Stevens C.E. et al.

J. Virol. 80:9519-9529(2006) · UniProtKB (1,441)

Recurrent KRAS codon 146 mutations in human colorectal cancer.

Edkins S., O'Meara S., Parker A., Stevens C., Reis M., Jones S., Greenman C., Davies H., Dalgliesh G., Forbes S. et al.

Cancer Biol. Ther. 5:928-932(2006) · Mapped (8)

PHOX2B mutation-confirmed congenital central hypoventilation syndrome: presentation in adulthood.

Antic N.A., Malow B.A., Lange N., McEvoy R.D., Olson A.L., Turkington P., Windisch W., Samuels M., Stevens C.A., Berry-Kravis E.M. et al.

Am. J. Respir. Crit. Care Med. 174:923-927(2006) · Mapped (1)

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