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How insulin engages its primary binding site on the insulin receptor.

Menting J.G., Whittaker J., Margetts M.B., Whittaker L.J., Kong G.K., Smith B.J., Watson C.J., Zakova L., Kletvikova E., Jiracek J. et al.

Nature 493:241-245(2013) · UniProtKB (1) · Mapped (14)

Biosynthesis of proTRH-derived peptides in prohormone convertase 1 and 2 knockout mice.

Cyr N.E., Stuart R.C., Zhu X., Steiner D.F., Nillni E.A.

Peptides 35:42-48(2012) · Mapped (7)

Disruption of proprotein convertase 1/3 (PC1/3) expression in mice causes innate immune defects and uncontrolled cytokine secretion.

Refaie S., Gagnon S., Gagnon H., Desjardins R., D'Anjou F., D'Orleans-Juste P., Zhu X., Steiner D.F., Seidah N.G., Lazure C. et al.

J. Biol. Chem. 287:14703-14717(2012) · Mapped (10)

MicroRNA-29 regulates T-box transcription factors and interferon-gamma production in helper T cells.

Steiner D.F., Thomas M.F., Hu J.K., Yang Z., Babiarz J.E., Allen C.D., Matloubian M., Blelloch R., Ansel K.M.

Immunity 35:169-181(2011) · Mapped (1)

GSK-3 inactivation or depletion promotes beta-cell replication via down regulation of the CDK inhibitor, p27 (Kip1).

Stein J., Milewski W.M., Hara M., Steiner D.F., Dey A.

Islets 3:21-34(2011) · Mapped (12)

Pim3 negatively regulates glucose-stimulated insulin secretion.

Vlacich G., Nawijn M.C., Webb G.C., Steiner D.F.

Islets 2:308-317(2010) · UniProtKB (2) · Mapped (6)

Clinical and molecular genetics of neonatal diabetes due to mutations in the insulin gene.

Stoy J., Steiner D.F., Park S.Y., Ye H., Philipson L.H., Bell G.I.

Rev Endocr Metab Disord 11:205-215(2010) · Mapped (3)

Distinct requirements of microRNAs in NK cell activation, survival, and function.

Bezman N.A., Cedars E., Steiner D.F., Blelloch R., Hesslein D.G., Lanier L.L.

J. Immunol. 185:3835-3846(2010) · Mapped (10)

Analysis of peptides in prohormone convertase 1/3 null mouse brain using quantitative peptidomics.

Wardman J.H., Zhang X., Gagnon S., Castro L.M., Zhu X., Steiner D.F., Day R., Fricker L.D.

J. Neurochem. 114:215-225(2010) · Mapped (8)

Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists.

Smith B.J., Huang K., Kong G., Chan S.J., Nakagawa S., Menting J.G., Hu S.Q., Whittaker J., Steiner D.F., Katsoyannis P.G. et al.

Proc. Natl. Acad. Sci. U.S.A. 107:6771-6776(2010) · UniProtKB (1) · Mapped (11)

Mutant proinsulin proteins associated with neonatal diabetes are retained in the endoplasmic reticulum and not efficiently secreted.

Park S.Y., Ye H., Steiner D.F., Bell G.I.

Biochem. Biophys. Res. Commun. 391:1449-1454(2010) · Mapped (4)

Neuropeptidomic analysis establishes a major role for prohormone convertase-2 in neuropeptide biosynthesis.

Zhang X., Pan H., Peng B., Steiner D.F., Pintar J.E., Fricker L.D.

J. Neurochem. 112:1168-1179(2010) · Mapped (6)

Defective neuropeptide processing and ischemic brain injury: a study on proprotein convertase 2 and its substrate neuropeptide in ischemic brains.

Zhan S., Zhao H., J White A., Minami M., Pignataro G., Yang T., Zhu X., Lan J., Xiong Z., Steiner D.F. et al.

J. Cereb. Blood Flow Metab. 29:698-706(2009) · Mapped (1)

Prohormone convertases 1/3 and 2 together orchestrate the site-specific cleavages of progastrin to release gastrin-34 and gastrin-17.

Rehfeld J.F., Zhu X., Norrbom C., Bundgaard J.R., Johnsen A.H., Nielsen J.E., Vikesaa J., Stein J., Dey A., Steiner D.F. et al.

Biochem. J. 415:35-43(2008) · Mapped (11)

Mutations in the insulin gene can cause MODY and autoantibody-negative type 1 diabetes.

Molven A., Ringdal M., Nordbo A.M., Raeder H., Stoy J., Lipkind G.M., Steiner D.F., Philipson L.H., Bergmann I., Aarskog D. et al.

Diabetes 57:1131-1135(2008) · UniProtKB (1) · Mapped (2)

Insulin mutation screening in 1,044 patients with diabetes: mutations in the INS gene are a common cause of neonatal diabetes but a rare cause of diabetes diagnosed in childhood or adulthood.

Edghill E.L., Flanagan S.E., Patch A.M., Boustred C., Parrish A., Shields B., Shepherd M.H., Hussain K., Kapoor R.R., Malecki M. et al.

Diabetes 57:1034-1042(2008) · UniProtKB (1) · Mapped (8)

The cell-specific pattern of cholecystokinin peptides in endocrine cells versus neurons is governed by the expression of prohormone convertases 1/3, 2, and 5/6.

Rehfeld J.F., Bundgaard J.R., Hannibal J., Zhu X., Norrbom C., Steiner D.F., Friis-Hansen L.

Endocrinology 149:1600-1608(2008) · Mapped (16)

The A-chain of insulin contacts the insert domain of the insulin receptor. Photo-cross-linking and mutagenesis of a diabetes-related crevice.

Huang K., Chan S.J., Hua Q.X., Chu Y.C., Wang R.Y., Klaproth B., Jia W., Whittaker J., De Meyts P., Nakagawa S.H. et al.

J. Biol. Chem. 282:35337-35349(2007) · Mapped (1)

Insulin gene mutations as a cause of permanent neonatal diabetes.

Stoy J., Edghill E.L., Flanagan S.E., Ye H., Paz V.P., Pluzhnikov A., Below J.E., Hayes M.G., Cox N.J., Lipkind G.M. et al.

Proc. Natl. Acad. Sci. U.S.A. 104:15040-15044(2007) · UniProtKB (1) · Mapped (10)

Nestin expression in pancreatic endocrine and exocrine cells of mice lacking glucagon signaling.

Kedees M.H., Guz Y., Vuguin P.M., Vargas C., Cui L., Steiner D.F., Charron M.J., Teitelman G.

Dev. Dyn. 236:1126-1133(2007) · Mapped (28)

On the processing of proghrelin to ghrelin.

Zhu X., Cao Y., Voogd K., Voodg K., Steiner D.F.

J. Biol. Chem. 281:38867-38870(2006) · Mapped (10)

The role of prohormone convertase-2 in hypothalamic neuropeptide processing: a quantitative neuropeptidomic study.

Pan H., Che F.Y., Peng B., Steiner D.F., Pintar J.E., Fricker L.D.

J. Neurochem. 98:1763-1777(2006) · Mapped (7)

Pancreatic beta cells lack a low glucose and O2-inducible mitochondrial protein that augments cell survival.

Wang J., Cao Y., Chen Y., Chen Y., Gardner P., Steiner D.F.

Proc. Natl. Acad. Sci. U.S.A. 103:10636-10641(2006) · UniProtKB (1) · Mapped (7)

Gene duplication and functional divergence of the zebrafish insulin-like growth factor 1 receptors.

Schlueter P.J., Royer T., Farah M.H., Laser B., Chan S.J., Steiner D.F., Duan C.

FASEB J. 20:1230-1232(2006) · Mapped (5)

Prohormone convertase 1/3 is essential for processing of the glucose-dependent insulinotropic polypeptide precursor.

Ugleholdt R., Poulsen M.L., Holst P.J., Irminger J.C., Orskov C., Pedersen J., Rosenkilde M.M., Zhu X., Steiner D.F., Holst J.J.

J. Biol. Chem. 281:11050-11057(2006) · Mapped (9)

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