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Literature citations Results

Structural basis for activation of the complement system by component C4 cleavage.

Kidmose R.T., Laursen N.S., Dobo J., Kjaer T.R., Sirotkina S., Yatime L., Sottrup-Jensen L., Thiel S., Gal P., Andersen G.R.

Proc. Natl. Acad. Sci. U.S.A. 109:15425-15430(2012) · Mapped (13)

The crystal structure of human alpha2-macroglobulin reveals a unique molecular cage.

Marrero A., Duquerroy S., Trapani S., Goulas T., Guevara T., Andersen G.R., Navaza J., Sottrup-Jensen L., Gomis-Ruth F.X.

Angew. Chem. Int. Ed. Engl. 51:3340-3344(2012) · Mapped (1)

Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex.

Laursen N.S., Andersen K.R., Braren I., Spillner E., Sottrup-Jensen L., Andersen G.R.

EMBO J. 30:606-616(2011) · UniProtKB (3)

Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus.

Laursen N.S., Gordon N., Hermans S., Lorenz N., Jackson N., Wines B., Spillner E., Christensen J.B., Jensen M., Fredslund F. et al.

Proc. Natl. Acad. Sci. U.S.A. 107:3681-3686(2010) · UniProtKB (2) · Mapped (3)

Structure of and influence of a tick complement inhibitor on human complement component 5.

Fredslund F., Laursen N.S., Roversi P., Jenner L., Oliveira C.L.P., Pedersen J.S., Nunn M.A., Lea S.M., Discipio R., Sottrup-Jensen L. et al.

Nat. Immunol. 9:753-760(2008) · UniProtKB (1)

The structure of bovine complement component 3 reveals the basis for thioester function.

Fredslund F., Jenner L., Husted L.B., Nyborg J., Andersen G.R., Sottrup-Jensen L.

J. Mol. Biol. 361:115-127(2006) · UniProtKB (1)

Proteinase inhibition by proform of eosinophil major basic protein (pro-MBP) is a multistep process of intra- and intermolecular disulfide rearrangements.

Glerup S., Boldt H.B., Overgaard M.T., Sottrup-Jensen L., Giudice L.C., Oxvig C.

J. Biol. Chem. 280:9823-9832(2005) · Mapped (9)

The Lin12-notch repeats of pregnancy-associated plasma protein-A bind calcium and determine its proteolytic specificity.

Boldt H.B., Kjaer-Sorensen K., Overgaard M.T., Weyer K., Poulsen C.B., Sottrup-Jensen L., Conover C.A., Giudice L.C., Oxvig C.

J. Biol. Chem. 279:38525-38531(2004) · Mapped (8)

Inhibition of proteolysis by the proform of eosinophil major basic protein (proMBP) requires covalent binding to its target proteinase.

Overgaard M.T., Glerup S., Boldt H.B., Rodacker V., Olsen I.M., Christiansen M., Sottrup-Jensen L., Giudice L.C., Oxvig C.

FEBS Lett. 560:147-152(2004) · Mapped (9)

Complex of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein. Disulfide structure and carbohydrate attachment sites.

Overgaard M.T., Sorensen E.S., Stachowiak D., Boldt H.B., Kristensen L., Sottrup-Jensen L., Oxvig C.

J. Biol. Chem. 278:2106-2117(2003) · UniProtKB (2) · Mapped (7)

Cell surface targeting of pregnancy-associated plasma protein A proteolytic activity. Reversible adhesion is mediated by two neighboring short consensus repeats.

Laursen L.S., Overgaard M.T., Weyer K., Boldt H.B., Ebbesen P., Christiansen M., Sottrup-Jensen L., Giudice L.C., Oxvig C.

J. Biol. Chem. 277:47225-47234(2002) · Mapped (9)

Substrate specificity of the metalloproteinase pregnancy-associated plasma protein-A (PAPP-A) assessed by mutagenesis and analysis of synthetic peptides: substrate residues distant from the scissile bond are critical for proteolysis.

Laursen L.S., Overgaard M.T., Nielsen C.G., Boldt H.B., Hopmann K.H., Conover C.A., Sottrup-Jensen L., Giudice L.C., Oxvig C.

Biochem. J. 367:31-40(2002) · Mapped (8)

Expression of recombinant murine pregnancy-associated plasma protein-A (PAPP-A) and a novel variant (PAPP-Ai) with differential proteolytic activity.

Soe R., Overgaard M.T., Thomsen A.R., Laursen L.S., Olsen I.M., Sottrup-Jensen L., Haaning J., Giudice L.C., Conover C.A., Oxvig C.

Eur. J. Biochem. 269:2247-2256(2002) · UniProtKB (1)

Pregnancy-associated plasma protein-A (PAPP-A) cleaves insulin-like growth factor binding protein (IGFBP)-5 independent of IGF: implications for the mechanism of IGFBP-4 proteolysis by PAPP-A.

Laursen L.S., Overgaard M.T., Soe R., Boldt H.B., Sottrup-Jensen L., Giudice L.C., Conover C.A., Oxvig C.

FEBS Lett. 504:36-40(2001) · UniProtKB (1)

Pregnancy-associated plasma protein-A2 (PAPP-A2), a novel insulin-like growth factor-binding protein-5 proteinase.

Overgaard M.T., Boldt H.B., Laursen L.S., Sottrup-Jensen L., Conover C.A., Oxvig C.

J. Biol. Chem. 276:21849-21853(2001) · UniProtKB (1)

Expression of recombinant human pregnancy-associated plasma protein-A and identification of the proform of eosinophil major basic protein as its physiological inhibitor.

Overgaard M.T., Haaning J., Boldt H.B., Olsen I.M., Laursen L.S., Christiansen M., Gleich G.J., Sottrup-Jensen L., Conover C.A., Oxvig C.

J. Biol. Chem. 275:31128-31133(2000) · UniProtKB (2)

Messenger ribonucleic acid levels of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein: expression in human reproductive and nonreproductive tissues.

Overgaard M.T., Oxvig C., Christiansen M., Lawrence J.B., Conover C.A., Gleich G.J., Sottrup-Jensen L., Haaning J.

Biol. Reprod. 61:1083-1089(1999) · UniProtKB (2)

Biochemical evidence for heme linkage through esters with Asp-93 and Glu-241 in human eosinophil peroxidase. The ester with Asp-93 is only partially formed in vivo.

Oxvig C., Thomsen A.R., Overgaard M.T., Sorensen E.S., Hoejrup P., Bjerrum M.J., Gleich G.J., Sottrup-Jensen L.

J. Biol. Chem. 274:16953-16958(1999) · UniProtKB (1)

The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A.

Lawrence J.B., Oxvig C., Overgaard M.T., Sottrup-Jensen L., Gleich G.J., Hays L.G., Yates J.R. III, Conover C.A.

Proc. Natl. Acad. Sci. U.S.A. 96:3149-3153(1999) · UniProtKB (1)

The crayfish plasma clotting protein: a vitellogenin-related protein responsible for clot formation in crustacean blood.

Hall M., Wang R., van Antwerpen R., Sottrup-Jensen L., Soderhall K.

Proc. Natl. Acad. Sci. U.S.A. 96:1965-1970(1999) · UniProtKB (1)

Crystal structure of the receptor-binding domain of alpha 2-macroglobulin.

Jenner L., Husted L., Thirup S., Sottrup-Jensen L., Nyborg J.

Structure 6:595-604(1998) · UniProtKB (1)

Characterisation of bovine structure-specific recognition protein 1 (SSRP1) cDNA.

Nielsen P.K., Haaning J., Sottrup-Jensen L.

Biochem. Mol. Biol. Int. 43:781-786(1997) · UniProtKB (1)

Pacifastin, a novel 155-kDa heterodimeric proteinase inhibitor containing a unique transferrin chain.

Liang Z., Sottrup-Jensen L., Aspan A., Hall M., Soderhall K.

Proc. Natl. Acad. Sci. U.S.A. 94:6682-6687(1997) · UniProtKB (2)

The complete amino acid sequence of human placental oxytocinase.

Laustsen P.G., Rasmussen T.E., Petersen K., Pedraza-Diaz S., Moestrup S.K., Gliemann J., Sottrup-Jensen L., Kristensen T.

Biochim. Biophys. Acta 1352:1-7(1997) · UniProtKB (1)

Molecular cloning of Limulus alpha 2-macroglobulin.

Iwaki D., Kawabata S., Miura Y., Kato A., Armstrong P.B., Quigley J.P., Nielsen K.L., Dolmer K., Sottrup-Jensen L., Iwanaga S.

Eur. J. Biochem. 242:822-831(1996) · UniProtKB (1)

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