| Maintenance of adult cardiac function requires the chromatin factor Asxl2. Lai H.L., Grachoff M., McGinley A.L., Khan F.F., Warren C.M., Chowdhury S.A., Wolska B.M., Solaro R.J., Geenen D.L., Wang Q.T.
J. Mol. Cell. Cardiol. 53:734-741(2012) · Mapped (9) |
| AMP-activated protein kinase phosphorylates cardiac troponin I at Ser-150 to increase myofilament calcium sensitivity and blunt PKA-dependent function. Nixon B.R., Thawornkaiwong A., Jin J., Brundage E.A., Little S.C., Davis J.P., Solaro R.J., Biesiadecki B.J.
J. Biol. Chem. 287:19136-19147(2012) · Mapped (4) |
| A novel cardiomyocyte-enriched microRNA, miR-378, targets insulin-like growth factor 1 receptor: implications in postnatal cardiac remodeling and cell survival. Knezevic I., Patel A., Sundaresan N.R., Gupta M.P., Solaro R.J., Nagalingam R.S., Gupta M.
J. Biol. Chem. 287:12913-12926(2012) · Mapped (5) |
| Pak1 as a novel therapeutic target for antihypertrophic treatment in the heart. Liu W., Zi M., Naumann R., Ulm S., Jin J., Taglieri D.M., Prehar S., Gui J., Tsui H., Xiao R.P. et al.
Circulation 124:2702-2715(2011) · Mapped (3) |
| p21-activated kinase improves cardiac contractility during ischemia-reperfusion concomitant with changes in troponin-T and myosin light chain 2 phosphorylation. Monasky M.M., Taglieri D.M., Patel B.G., Chernoff J., Wolska B.M., Ke Y., Solaro R.J.
Am. J. Physiol. Heart Circ. Physiol. 302:H224-30(2012) · Mapped (8) |
| Enhanced activation of p21-activated kinase 1 in heart failure contributes to dephosphorylation of connexin 43. Ai X., Jiang A., Ke Y., Solaro R.J., Pogwizd S.M.
Cardiovasc. Res. 92:106-114(2011) · Mapped (11) |
| Expression of tropomyosin-kappa induces dilated cardiomyopathy and depresses cardiac myofilament tension by mechanisms involving cross-bridge dependent activation and altered tropomyosin phosphorylation. Karam C.N., Warren C.M., Rajan S., de Tombe P.P., Wieczorek D.F., Solaro R.J.
J. Muscle Res. Cell. Motil. 31:315-322(2011) · Mapped (12) |
| Molecular and functional characterization of a novel cardiac-specific human tropomyosin isoform. Rajan S., Jagatheesan G., Karam C.N., Alves M.L., Bodi I., Schwartz A., Bulcao C.F., D'Souza K.M., Akhter S.A., Boivin G.P. et al.
Circulation 121:410-418(2010) · Mapped (19) |
| Differential effects of phosphorylation of regions of troponin I in modifying cooperative activation of cardiac thin filaments. Engel P.L., Hinken A., Solaro R.J.
J. Mol. Cell. Cardiol. 47:359-364(2009) · Mapped (4) |
| Sites of intra- and intermolecular cross-linking of the N-terminal extension of troponin I in human cardiac whole troponin complex. Warren C.M., Kobayashi T., Solaro R.J.
J. Biol. Chem. 284:14258-14266(2009) · Mapped (4) |
| Expression of active p21-activated kinase-1 induces Ca2+ flux modification with altered regulatory protein phosphorylation in cardiac myocytes. Sheehan K.A., Ke Y., Wolska B.M., Solaro R.J.
Am. J. Physiol., Cell Physiol. 296:C47-58(2009) · Mapped (5) |
| Tyrosine phosphorylation modifies protein kinase C delta-dependent phosphorylation of cardiac troponin I. Sumandea M.P., Rybin V.O., Hinken A.C., Wang C., Kobayashi T., Harleton E., Sievert G., Balke C.W., Feinmark S.J., Solaro R.J. et al.
J. Biol. Chem. 283:22680-22689(2008) · UniProtKB (1) |
| Increased cross-bridge cycling kinetics after exchange of C-terminal truncated troponin I in skinned rat cardiac muscle. Tachampa K., Kobayashi T., Wang H., Martin A.F., Biesiadecki B.J., Solaro R.J., de Tombe P.P.
J. Biol. Chem. 283:15114-15121(2008) · Mapped (2) |
| Phosphorylation-dependent conformational transition of the cardiac specific N-extension of troponin I in cardiac troponin. Howarth J.W., Meller J., Solaro R.J., Trewhella J., Rosevear P.R.
J. Mol. Biol. 373:706-722(2007) · UniProtKB (1) |
| Augmented protein kinase C-alpha-induced myofilament protein phosphorylation contributes to myofilament dysfunction in experimental congestive heart failure. Belin R.J., Sumandea M.P., Allen E.J., Schoenfelt K., Wang H., Solaro R.J., de Tombe P.P.
Circ. Res. 101:195-204(2007) · Mapped (3) |
| Dilated cardiomyopathy mutant tropomyosin mice develop cardiac dysfunction with significantly decreased fractional shortening and myofilament calcium sensitivity. Rajan S., Ahmed R.P., Jagatheesan G., Petrashevskaya N., Boivin G.P., Urboniene D., Arteaga G.M., Wolska B.M., Solaro R.J., Liggett S.B. et al.
Circ. Res. 101:205-214(2007) · Mapped (18) |
| PKCepsilon increases phosphorylation of the cardiac myosin binding protein C at serine 302 both in vitro and in vivo. Xiao L., Zhao Q., Du Y., Yuan C., Solaro R.J., Buttrick P.M.
Biochemistry 46:7054-7061(2007) · Mapped (6) |
| The troponin C G159D mutation blunts myofilament desensitization induced by troponin I Ser23/24 phosphorylation. Biesiadecki B.J., Kobayashi T., Walker J.S., Solaro R.J., de Tombe P.P.
Circ. Res. 100:1486-1493(2007) · Mapped (2) |
| Rescue of tropomyosin-induced familial hypertrophic cardiomyopathy mice by transgenesis. Jagatheesan G., Rajan S., Petrashevskaya N., Schwartz A., Boivin G., Arteaga G.M., Solaro R.J., Liggett S.B., Wieczorek D.F.
Am. J. Physiol. Heart Circ. Physiol. 293:H949-58(2007) · Mapped (12) |
| p38-MAPK induced dephosphorylation of alpha-tropomyosin is associated with depression of myocardial sarcomeric tension and ATPase activity. Vahebi S., Ota A., Li M., Warren C.M., de Tombe P.P., Wang Y., Solaro R.J.
Circ. Res. 100:408-415(2007) · Mapped (15) |
| Identification of a region of troponin I important in signaling cross-bridge-dependent activation of cardiac myofilaments. Engel P.L., Kobayashi T., Biesiadecki B., Davis J., Tikunova S., Wu S., Solaro R.J.
J. Biol. Chem. 282:183-193(2007) · Mapped (3) |
| Control of cardiac myofilament activation and PKC-betaII signaling through the actin capping protein, CapZ. Pyle W.G., La Rotta G., de Tombe P.P., Sumandea M.P., Solaro R.J.
J. Mol. Cell. Cardiol. 41:537-543(2006) · Mapped (8) |
| Partial replacement of cardiac troponin I with a non-phosphorylatable mutant at serines 43/45 attenuates the contractile dysfunction associated with PKCepsilon phosphorylation. Scruggs S.B., Walker L.A., Lyu T., Geenen D.L., Solaro R.J., Buttrick P.M., Goldspink P.H.
J. Mol. Cell. Cardiol. 40:465-473(2006) · UniProtKB (2) · Mapped (2) |
| Specific enhancement of sarcomeric response to Ca2+ protects murine myocardium against ischemia-reperfusion dysfunction. Arteaga G.M., Warren C.M., Milutinovic S., Martin A.F., Solaro R.J.
Am. J. Physiol. Heart Circ. Physiol. 289:H2183-92(2005) · Mapped (4) |
| Protection against endotoxemia-induced contractile dysfunction in mice with cardiac-specific expression of slow skeletal troponin I. Layland J., Cave A.C., Warren C., Grieve D.J., Sparks E., Kentish J.C., Solaro R.J., Shah A.M.
FASEB J. 19:1137-1139(2005) · Mapped (4) |
