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Phleboviruses encapsidate their genomes by sequestering RNA bases.

Raymond D.D., Piper M.E., Gerrard S.R., Skiniotis G., Smith J.L.

Proc. Natl. Acad. Sci. U.S.A. 109:19208-19213(2012) · UniProtKB (1) · Mapped (1)

APOBEC3G restricts HIV-1 to a greater extent than APOBEC3F and APOBEC3DE in human primary CD4+ t cells and macrophages.

Chaipan C., Smith J.L., Hu W.S., Pathak V.K.

J. Virol. 87:444-453(2013) · UniProtKB (4) · Mapped (6)

Structural basis of functional group activation by sulfotransferases in complex metabolic pathways.

McCarthy J.G., Eisman E.B., Kulkarni S., Gerwick L., Gerwick W.H., Wipf P., Sherman D.H., Smith J.L.

ACS Chem. Biol. 7:1994-2003(2012) · UniProtKB (2)

Biochemical and structural characterization of germicidin synthase: analysis of a type III polyketide synthase that employs acyl-ACP as a starter unit donor.

Chemler J.A., Buchholz T.J., Geders T.W., Akey D.L., Rath C.M., Chlipala G.E., Smith J.L., Sherman D.H.

J. Am. Chem. Soc. 134:7359-7366(2012) · UniProtKB (1)

Loss of FXR protects against diet-induced obesity and accelerates liver carcinogenesis in ob/ob mice.

Zhang Y., Ge X., Heemstra L.A., Chen W.D., Xu J., Smith J.L., Ma H., Kasim N., Edwards P.A., Novak C.M.

Mol. Endocrinol. 26:272-280(2012) · Mapped (4)

Structure and activity of DmmA, a marine haloalkane dehalogenase.

Gehret J.J., Gu L., Geders T.W., Brown W.C., Gerwick L., Gerwick W.H., Sherman D.H., Smith J.L.

Protein Sci. 21:239-248(2012) · UniProtKB (1)

A new structural form in the SAM/metal-dependent o-methyltransferase family: MycE from the mycinamicin biosynthetic pathway.

Akey D.L., Li S., Konwerski J.R., Confer L.A., Bernard S.M., Anzai Y., Kato F., Sherman D.H., Smith J.L.

J. Mol. Biol. 413:438-450(2011) · UniProtKB (1)

Structural basis of multifunctionality in a vitamin B12-processing enzyme.

Koutmos M., Gherasim C., Smith J.L., Banerjee R.

J. Biol. Chem. 286:29780-29787(2011) · Mapped (1)

Structure and function of the RedJ protein, a thioesterase from the prodiginine biosynthetic pathway in Streptomyces coelicolor.

Whicher J.R., Florova G., Sydor P.K., Singh R., Alhamadsheh M., Challis G.L., Reynolds K.A., Smith J.L.

J. Biol. Chem. 286:22558-22569(2011) · UniProtKB (1)

Trafficking-deficient hERG K⁺ channels linked to long QT syndrome are regulated by a microtubule-dependent quality control compartment in the ER.

Smith J.L., McBride C.M., Nataraj P.S., Bartos D.C., January C.T., Delisle B.P.

Am. J. Physiol., Cell Physiol. 301:C75-85(2011) · Mapped (14)

Terminal alkene formation by the thioesterase of curacin A biosynthesis: structure of a decarboxylating thioesterase.

Gehret J.J., Gu L., Gerwick W.H., Wipf P., Sherman D.H., Smith J.L.

J. Biol. Chem. 286:14445-14454(2011) · UniProtKB (1)

Structural basis for substrate activation and regulation by cystathionine beta-synthase (CBS) domains in cystathionine {beta}-synthase.

Koutmos M., Kabil O., Smith J.L., Banerjee R.

Proc. Natl. Acad. Sci. U.S.A. 107:20958-20963(2010) · UniProtKB (1)

Conformational switch triggered by alpha-ketoglutarate in a halogenase of curacin A biosynthesis.

Khare D., Wang B., Gu L., Razelun J., Sherman D.H., Gerwick W.H., Hakansson K., Smith J.L.

Proc. Natl. Acad. Sci. U.S.A. 107:14099-14104(2010) · UniProtKB (1)

Biochemical and structural characterization of the tautomycetin thioesterase: analysis of a stereoselective polyketide hydrolase.

Scaglione J.B., Akey D.L., Sullivan R., Kittendorf J.D., Rath C.M., Kim E.S., Smith J.L., Sherman D.H.

Angew. Chem. Int. Ed. Engl. 49:5726-5730(2010) · UniProtKB (1)

Structure of the Rift Valley fever virus nucleocapsid protein reveals another architecture for RNA encapsidation.

Raymond D.D., Piper M.E., Gerrard S.R., Smith J.L.

Proc. Natl. Acad. Sci. U.S.A. 107:11769-11774(2010) · UniProtKB (1)

Crystal structures of dehydratase domains from the curacin polyketide biosynthetic pathway.

Akey D.L., Razelun J.R., Tehranisa J., Sherman D.H., Gerwick W.H., Smith J.L.

Structure 18:94-105(2010) · UniProtKB (4)

Insights into the reactivation of cobalamin-dependent methionine synthase.

Koutmos M., Datta S., Pattridge K.A., Smith J.L., Matthews R.G.

Proc. Natl. Acad. Sci. U.S.A. 106:18527-18532(2009) · Mapped (1)

Polyketide decarboxylative chain termination preceded by o-sulfonation in curacin a biosynthesis.

Gu L., Wang B., Kulkarni A., Gehret J.J., Lloyd K.R., Gerwick L., Gerwick W.H., Wipf P., Hakansson K., Smith J.L. et al.

J. Am. Chem. Soc. 131:16033-16035(2009) · UniProtKB (4)

Insights into tRNA-dependent amidotransferase evolution and catalysis from the structure of the Aquifex aeolicus enzyme.

Wu J., Bu W., Sheppard K., Kitabatake M., Kwon S.T., Soll D., Smith J.L.

J. Mol. Biol. 391:703-716(2009) · Mapped (3)

Adiponectin identified as an agonist for PAQR3/RKTG using a yeast-based assay system.

Garitaonandia I., Smith J.L., Kupchak B.R., Lyons T.J.

J. Recept. Signal Transduct. Res. 29:67-73(2009) · Mapped (5)

Alterations of zinc transporter proteins ZnT-1, ZnT-4 and ZnT-6 in preclinical Alzheimer's disease brain.

Lyubartseva G., Smith J.L., Markesbery W.R., Lovell M.A.

Brain Pathol. 20:343-350(2010) · Mapped (8)

Adaptations to submarine hydrothermal environments exemplified by the genome of Nautilia profundicola.

Campbell B.J., Smith J.L., Hanson T.E., Klotz M.G., Stein L.Y., Lee C.K., Wu D., Robinson J.M., Khouri H.M., Eisen J.A. et al.

PLoS Genet. 5:E1000362-E1000362(2009) · UniProtKB (1,730)

Structural basis for binding specificity between subclasses of modular polyketide synthase docking domains.

Buchholz T.J., Geders T.W., Bartley F.E., Reynolds K.A., Smith J.L., Sherman D.H.

ACS Chem. Biol. 4:41-52(2009) · UniProtKB (2)

Structure and functional analysis of RifR, the type II thioesterase from the rifamycin biosynthetic pathway.

Claxton H.B., Akey D.L., Silver M.K., Admiraal S.J., Smith J.L.

J. Biol. Chem. 284:5021-5029(2009) · UniProtKB (1)

Optimization of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity.

Chamberlain S.D., Redman A.M., Wilson J.W., Deanda F., Shotwell J.B., Gerding R., Lei H., Yang B., Stevens K.L., Hassell A.M. et al.

Bioorg. Med. Chem. Lett. 19:360-364(2009) · UniProtKB (1) · Mapped (1)

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