1 - 25 of 64 results for author:"Silman I." in Literature citations
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| Structural and functional characterization of the interaction of the photosensitizing probe methylene blue with Torpedo californica acetylcholinesterase. Paz A., Roth E., Ashani Y., Xu Y., Shnyrov V.L., Sussman J.L., Silman I., Weiner L. Protein Sci. 21:1138-1152(2012) · Mapped (1) |
| Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis. Khare S.D., Kipnis Y., Greisen P. Jr., Takeuchi R., Ashani Y., Goldsmith M., Song Y., Gallaher J.L., Silman I., Leader H. et al. Nat. Chem. Biol. 8:294-300(2012) · Mapped (1) |
| Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations. Xu Y., Li M.J., Greenblatt H., Chen W., Paz A., Dym O., Peleg Y., Chen T., Shen X., He J. et al. Acta Crystallogr. D Biol. Crystallogr. 68:13-25(2012) · Mapped (11) |
| Comparison of a molecular dynamics model with the X-ray structure of the N370S acid-beta-glucosidase mutant that causes Gaucher disease. Offman M.N., Krol M., Rost B., Silman I., Sussman J.L., Futerman A.H. Protein Eng. Des. Sel. 24:773-775(2011) · Mapped (3) |
| Backdoor opening mechanism in acetylcholinesterase based on X-ray crystallography and molecular dynamics simulations. Sanson B., Colletier J.P., Xu Y., Lang P.T., Jiang H., Silman I., Sussman J.L., Weik M. Protein Sci. 20:1114-1118(2011) · Mapped (1) |
| Cyclodextrin-mediated crystallization of acid beta-glucosidase in complex with amphiphilic bicyclic nojirimycin analogues. Brumshtein B., Aguilar-Moncayo M., Benito J.M., Garcia Fernandez J.M., Silman I., Shaaltiel Y., Aviezer D., Sussman J.L., Futerman A.H., Ortiz Mellet C. Org. Biomol. Chem. 9:4160-4167(2011) · Mapped (1) |
| Acetylcholinesterase: from 3D structure to function. Dvir H., Silman I., Harel M., Rosenberry T.L., Sussman J.L. Chem. Biol. Interact. 187:10-22(2010) · Mapped (3) |
| The quaternary structure of amalgam, a Drosophila neuronal adhesion protein, explains its dual adhesion properties. Zeev-Ben-Mordehai T., Mylonas E., Paz A., Peleg Y., Toker L., Silman I., Svergun D.I., Sussman J.L. Biophys. J. 97:2316-2326(2009) · Mapped (3) |
| Characterization of gene-activated human acid-beta-glucosidase: crystal structure, glycan composition, and internalization into macrophages. Brumshtein B., Salinas P., Peterson B., Chan V., Silman I., Sussman J.L., Savickas P.J., Robinson G.S., Futerman A.H. Glycobiology 20:24-32(2010) · Mapped (1) |
| Crystallographic snapshots of nonaged and aged conjugates of soman with acetylcholinesterase, and of a ternary complex of the aged conjugate with pralidoxime. Sanson B., Nachon F., Colletier J.P., Froment M.T., Toker L., Greenblatt H.M., Sussman J.L., Ashani Y., Masson P., Silman I. et al. J. Med. Chem. 52:7593-7603(2009) · UniProtKB (1) |
| Directed evolution of serum paraoxonase PON3 by family shuffling and ancestor/consensus mutagenesis, and its biochemical characterization. Khersonsky O., Rosenblat M., Toker L., Yacobson S., Hugenmatter A., Silman I., Sussman J.L., Aviram M., Tawfik D.S. Biochemistry 48:6644-6654(2009) · Mapped (2) |
| 6-Amino-6-deoxy-5,6-di-N-(N'-octyliminomethylidene)nojirimycin: synthesis, biological evaluation, and crystal structure in complex with acid beta-glucosidase. Brumshtein B., Aguilar-Moncayo M., Garcia-Moreno M.I., Ortiz Mellet C., Garcia Fernandez J.M., Silman I., Shaaltiel Y., Aviezer D., Sussman J.L., Futerman A.H. Chembiochem 10:1480-1485(2009) · Mapped (1) |
| The crystal structure of a complex of acetylcholinesterase with a bis-(-)-nor-meptazinol derivative reveals disruption of the catalytic triad. Paz A., Xie Q., Greenblatt H.M., Fu W., Tang Y., Silman I., Qiu Z., Sussman J.L. J. Med. Chem. 52:2543-2549(2009) · Mapped (1) |
| Direct correlation between molecular dynamics and enzymatic stability: a comparative neutron scattering study of native human butyrylcholinesterase and its "aged" soman conjugate. Gabel F., Masson P., Froment M.T., Doctor B.P., Saxena A., Silman I., Zaccai G., Weik M. Biophys. J. 96:1489-1494(2009) · Mapped (3) |
| Amalgam, an axon guidance Drosophila adhesion protein belonging to the immunoglobulin superfamily: over-expression, purification and biophysical characterization. Zeev-Ben-Mordehai T., Paz A., Peleg Y., Toker L., Wolf S.G., Rydberg E.H., Sussman J.L., Silman I. Protein Expr. Purif. 63:147-157(2009) · Mapped (4) |
| Acid beta-glucosidase: insights from structural analysis and relevance to Gaucher disease therapy. Kacher Y., Brumshtein B., Boldin-Adamsky S., Toker L., Shainskaya A., Silman I., Sussman J.L., Futerman A.H. Biol. Chem. 389:1361-1369(2008) · Mapped (1) |
| Shoot-and-Trap: use of specific x-ray damage to study structural protein dynamics by temperature-controlled cryo-crystallography. Colletier J.P., Bourgeois D., Sanson B., Fournier D., Sussman J.L., Silman I., Weik M. Proc. Natl. Acad. Sci. U.S.A. 105:11742-11747(2008) · Mapped (1) |
| Crystal structure of thioflavin T bound to the peripheral site of Torpedo californica acetylcholinesterase reveals how thioflavin T acts as a sensitive fluorescent reporter of ligand binding to the acylation site. Harel M., Sonoda L.K., Silman I., Sussman J.L., Rosenberry T.L. J. Am. Chem. Soc. 130:7856-7861(2008) · Mapped (1) |
| Use of a 'caged' analogue to study the traffic of choline within acetylcholinesterase by kinetic crystallography. Colletier J.P., Royant A., Specht A., Sanson B., Nachon F., Masson P., Zaccai G., Sussman J.L., Goeldner M., Silman I. et al. Acta Crystallogr. D Biol. Crystallogr. 63:1115-1128(2007) · Mapped (1) |
| Structural disorder serves as a weak signal for intracellular protein degradation. Tompa P., Prilusky J., Silman I., Sussman J.L. Proteins 71:903-909(2008) · Mapped (15) |
| Crystal structures of complexes of N-butyl- and N-nonyl-deoxynojirimycin bound to acid beta-glucosidase: insights into the mechanism of chemical chaperone action in Gaucher disease. Brumshtein B., Greenblatt H.M., Butters T.D., Shaaltiel Y., Aviezer D., Silman I., Futerman A.H., Sussman J.L. J. Biol. Chem. 282:29052-29058(2007) · Mapped (1) |
| Production of glucocerebrosidase with terminal mannose glycans for enzyme replacement therapy of Gaucher's disease using a plant cell system. Shaaltiel Y., Bartfeld D., Hashmueli S., Baum G., Brill-Almon E., Galili G., Dym O., Boldin-Adamsky S.A., Silman I., Sussman J.L. et al. Plant Biotechnol. J. 5:579-590(2007) · Mapped (1) |
| Structural comparison of differently glycosylated forms of acid-beta-glucosidase, the defective enzyme in Gaucher disease. Brumshtein B., Wormald M.R., Silman I., Futerman A.H., Sussman J.L. Acta Crystallogr. D 62:1458-1465(2006) · UniProtKB (1) |
| Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge. Rydberg E.H., Brumshtein B., Greenblatt H.M., Wong D.M., Shaya D., Williams L.D., Carlier P.R., Pang Y.P., Silman I., Sussman J.L. J. Med. Chem. 49:5491-5500(2006) · Mapped (1) |
| Structural insights into substrate traffic and inhibition in acetylcholinesterase. Colletier J.-P., Fournier D., Greenblatt H.M., Stojan J., Sussman J.L., Zaccai G., Silman I., Weik M. EMBO J. 25:2746-2756(2006) · UniProtKB (1) |