1 - 25 of 112 results for author:"Shokat K.M." in Literature citations
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| Chemical genetics reveals a specific requirement for Cdk2 activity in the DNA damage response and identifies Nbs1 as a Cdk2 substrate in human cells. Wohlbold L., Merrick K.A., De S., Amat R., Kim J.H., Larochelle S., Allen J.J., Zhang C., Shokat K.M., Petrini J.H. et al. PLoS Genet. 8:e1002935-e1002935(2012) · Mapped (3) |
| Integrin alpha9beta1 in airway smooth muscle suppresses exaggerated airway narrowing. Chen C., Kudo M., Rutaganira F., Takano H., Lee C., Atakilit A., Robinett K.S., Uede T., Wolters P.J., Shokat K.M. et al. J. Clin. Invest. 122:2916-2927(2012) · Mapped (15) |
| Chemical genetic discovery of targets and anti-targets for cancer polypharmacology. Dar A.C., Das T.K., Shokat K.M., Cagan R.L. Nature 486:80-84(2012) · Mapped (16) |
| Chemical-genetic analysis of cyclin dependent kinase 2 function reveals an important role in cellular transformation by multiple oncogenic pathways. Horiuchi D., Huskey N.E., Kusdra L., Wohlbold L., Merrick K.A., Zhang C., Creasman K.J., Shokat K.M., Fisher R.P., Goga A. Proc. Natl. Acad. Sci. U.S.A. 109:E1019-27(2012) · Mapped (7) |
| Chemical genetic identification of NDR1/2 kinase substrates AAK1 and Rabin8 Uncovers their roles in dendrite arborization and spine development. Ultanir S.K., Hertz N.T., Li G., Ge W.P., Burlingame A.L., Pleasure S.J., Shokat K.M., Jan L.Y., Jan Y.N. Neuron 73:1127-1142(2012) · Mapped (4) |
| The translational landscape of mTOR signalling steers cancer initiation and metastasis. Hsieh A.C., Liu Y., Edlind M.P., Ingolia N.T., Janes M.R., Sher A., Shi E.Y., Stumpf C.R., Christensen C., Bonham M.J. et al. Nature 485:55-61(2012) · Mapped (5) |
| Development of a chemical genetic approach for human aurora B kinase identifies novel substrates of the chromosomal passenger complex. Hengeveld R.C., Hertz N.T., Vromans M.J., Zhang C., Burlingame A.L., Shokat K.M., Lens S.M. Mol. Cell Proteomics 11:47-59(2012) · Mapped (4) |
| The in vivo response of stem and other undifferentiated spermatogonia to the reversible inhibition of glial cell line-derived neurotrophic factor signaling in the adult. Savitt J., Singh D., Zhang C., Chen L.C., Folmer J., Shokat K.M., Wright W.W. Stem Cells 30:732-740(2012) · Mapped (3) |
| Chemical genetic screen for AMPKalpha2 substrates uncovers a network of proteins involved in mitosis. Banko M.R., Allen J.J., Schaffer B.E., Wilker E.W., Tsou P., White J.L., Villen J., Wang B., Kim S.R., Sakamoto K. et al. Mol. Cell 44:878-892(2011) · Mapped (3) |
| Feedback circuits monitor and adjust Basal lck-dependent events in T cell receptor signaling. Schoenborn J.R., Tan Y.X., Zhang C., Shokat K.M., Weiss A. |
| The mammalian target of rapamycin regulates cholesterol biosynthetic gene expression and exhibits a rapamycin-resistant transcriptional profile. Wang B.T., Ducker G.S., Barczak A.J., Barbeau R., Erle D.J., Shokat K.M. Proc. Natl. Acad. Sci. U.S.A. 108:15201-15206(2011) · Mapped (7) |
| Chemical genetic strategy for targeting protein kinases based on covalent complementarity. Garske A.L., Peters U., Cortesi A.T., Perez J.L., Shokat K.M. Proc. Natl. Acad. Sci. U.S.A. 108:15046-15052(2011) · Mapped (1) |
| TrkB and protein kinase Mzeta regulate synaptic localization of PSD-95 in developing cortex. Yoshii A., Murata Y., Kim J., Zhang C., Shokat K.M., Constantine-Paton M. J. Neurosci. 31:11894-11904(2011) · Mapped (18) |
| Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1. Korennykh A.V., Egea P.F., Korostelev A.A., Finer-Moore J., Stroud R.M., Zhang C., Shokat K.M., Walter P. BMC Biol. 9:48-48(2011) · Mapped (1) |
| Structural and functional basis for RNA cleavage by Ire1. Korennykh A.V., Korostelev A.A., Egea P.F., Finer-Moore J., Stroud R.M., Zhang C., Shokat K.M., Walter P. BMC Biol. 9:47-47(2011) · Mapped (2) |
| Switching Cdk2 on or off with small molecules to reveal requirements in human cell proliferation. Merrick K.A., Wohlbold L., Zhang C., Allen J.J., Horiuchi D., Huskey N.E., Goga A., Shokat K.M., Fisher R.P. Mol. Cell 42:624-636(2011) · Mapped (3) |
| A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK. Brennan D.F., Dar A.C., Hertz N.T., Chao W.C., Burlingame A.L., Shokat K.M., Barford D. |
| Rewiring of genetic networks in response to DNA damage. Bandyopadhyay S., Mehta M., Kuo D., Sung M.K., Chuang R., Jaehnig E.J., Bodenmiller B., Licon K., Copeland W., Shales M. et al. Science 330:1385-1389(2010) · Mapped (12) |
| Akt and autophagy cooperate to promote survival of drug-resistant glioma. Fan Q.W., Cheng C., Hackett C., Feldman M., Houseman B.T., Nicolaides T., Haas-Kogan D., James C.D., Oakes S.A., Debnath J. et al. Sci Signal 3:ra81-ra81(2010) · Mapped (17) |
| A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity. Au-Yeung B.B., Levin S.E., Zhang C., Hsu L.Y., Cheng D.A., Killeen N., Shokat K.M., Weiss A. Nat. Immunol. 11:1085-1092(2010) · Mapped (1) |
| A kinase cascade leading to Rab11-FIP5 controls transcytosis of the polymeric immunoglobulin receptor. Su T., Bryant D.M., Luton F., Verges M., Ulrich S.M., Hansen K.C., Datta A., Eastburn D.J., Burlingame A.L., Shokat K.M. et al. Nat. Cell Biol. 12:1143-1153(2010) · Mapped (12) |
| GABAA receptor trafficking is regulated by protein kinase C(epsilon) and the N-ethylmaleimide-sensitive factor. Chou W.H., Wang D., McMahon T., Qi Z.H., Song M., Zhang C., Shokat K.M., Messing R.O. J. Neurosci. 30:13955-13965(2010) · Mapped (5) |
| Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling. Maciejowski J., George K.A., Terret M.E., Zhang C., Shokat K.M., Jallepalli P.V. J. Cell Biol. 190:89-100(2010) · Mapped (2) |
| Chemical genetic inhibition of Mps1 in stable human cell lines reveals novel aspects of Mps1 function in mitosis. Sliedrecht T., Zhang C., Shokat K.M., Kops G.J. PLoS ONE 5:e10251-e10251(2010) · Mapped (2) |
| Shaping development of autophagy inhibitors with the structure of the lipid kinase Vps34. Miller S., Tavshanjian B., Oleksy A., Perisic O., Houseman B.T., Shokat K.M., Williams R.L. |