1 - 25 of 54 results for author:"Sharp S." in Literature citations
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| Co-crystalization and in vitro biological characterization of 5-aryl-4-(5-substituted-2-4-dihydroxyphenyl)-1,2,3-thiadiazole Hsp90 inhibitors. Sharp S.Y., Roe S.M., Kazlauskas E., Cikotiene I., Workman P., Matulis D., Prodromou C. PLoS ONE 7:e44642-e44642(2012) · Mapped (1) |
| Sequencing of the ANKYRIN 3 gene (ANK3) encoding ankyrin G in bipolar disorder reveals a non-conservative amino acid change in a short isoform of ankyrin G. Dedman A., McQuillin A., Kandaswamy R., Sharp S., Anjorin A., Gurling H. Am. J. Med. Genet. B Neuropsychiatr. Genet. 159B:328-335(2012) · Mapped (9) |
| Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children. Kilpelainen T.O., Qi L., Brage S., Sharp S.J., Sonestedt E., Demerath E., Ahmad T., Mora S., Kaakinen M., Sandholt C.H. et al. PLoS Med. 8:e1001116-e1001116(2011) · Mapped (4) |
| Targeting the Hsp90 molecular chaperone with novel macrolactams. Synthesis, structural, binding, and cellular studies. Day J.E., Sharp S.Y., Rowlands M.G., Aherne W., Hayes A., Raynaud F.I., Lewis W., Roe S.M., Prodromou C., Pearl L.H. et al. ACS Chem. Biol. 6:1339-1347(2011) · Mapped (1) |
| Association of genetic Loci with glucose levels in childhood and adolescence: a meta-analysis of over 6,000 children. Barker A., Sharp S.J., Timpson N.J., Bouatia-Naji N., Warrington N.M., Kanoni S., Beilin L.J., Brage S., Deloukas P., Evans D.M. et al. Diabetes 60:1805-1812(2011) · Mapped (18) |
| Genetic associations of autopsy-confirmed vascular dementia subtypes. Jones E.L., Kalaria R.N., Sharp S.I., O'Brien J.T., Francis P.T., Ballard C.G. Dement Geriatr Cogn Disord 31:247-253(2011) · Mapped (20) |
| MGMT-independent temozolomide resistance in pediatric glioblastoma cells associated with a PI3-kinase-mediated HOX/stem cell gene signature. Gaspar N., Marshall L., Perryman L., Bax D.A., Little S.E., Viana-Pereira M., Sharp S.Y., Vassal G., Pearson A.D., Reis R.M. et al. Cancer Res. 70:9243-9252(2010) · Mapped (9) |
| Genetic susceptibility to obesity and related traits in childhood and adolescence: influence of loci identified by genome-wide association studies. den Hoed M., Ekelund U., Brage S., Grontved A., Zhao J.H., Sharp S.J., Ong K.K., Wareham N.J., Loos R.J. Diabetes 59:2980-2988(2010) · Mapped (40) |
| Inhibition of Hsp90 with resorcylic acid macrolactones: synthesis and binding studies. Day J.E., Sharp S.Y., Rowlands M.G., Aherne W., Lewis W., Roe S.M., Prodromou C., Pearl L.H., Workman P., Moody C.J. Chemistry 16:10366-10372(2010) · Mapped (2) |
| Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease. Thambisetty M., Simmons A., Velayudhan L., Hye A., Campbell J., Zhang Y., Wahlund L.O., Westman E., Kinsey A., Guntert A. et al. Arch. Gen. Psychiatry 67:739-748(2010) · Mapped (5) |
| Genetic markers of adult obesity risk are associated with greater early infancy weight gain and growth. Elks C.E., Loos R.J., Sharp S.J., Langenberg C., Ring S.M., Timpson N.J., Ness A.R., Davey Smith G., Dunger D.B., Wareham N.J. et al. PLoS Med. 7:e1000284-e1000284(2010) · Mapped (18) |
| Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans. Ingelsson E., Langenberg C., Hivert M.F., Prokopenko I., Lyssenko V., Dupuis J., Magi R., Sharp S., Jackson A.U., Assimes T.L. et al. Diabetes 59:1266-1275(2010) · Mapped (29) |
| New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. DIAGRAM Consortium Nat. Genet. 42:105-116(2010) · Mapped (94) |
| Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Saxena R., Hivert M.F., Langenberg C., Tanaka T., Pankow J.S., Vollenweider P., Lyssenko V., Bouatia-Naji N., Dupuis J., Jackson A.U. et al. Nat. Genet. 42:142-148(2010) · Mapped (48) |
| Repressive and non-repressive chromatin at native telomeres in Saccharomyces cerevisiae. Loney E.R., Inglis P.W., Sharp S., Pryde F.E., Kent N.A., Mellor J., Louis E.J. Epigenetics Chromatin 2:18-18(2009) · Mapped (10) |
| Choline acetyltransferase activity in vascular dementia and stroke. Sharp S.I., Francis P.T., Elliott M.S., Kalaria R.N., Bajic N., Hortobagyi T., Ballard C.G. Dement Geriatr Cogn Disord 28:233-238(2009) · Mapped (8) |
| Segregating YKU80 and TLC1 alleles underlying natural variation in telomere properties in wild yeast. Liti G., Haricharan S., Cubillos F.A., Tierney A.L., Sharp S., Bertuch A.A., Parts L., Bailes E., Louis E.J. PLoS Genet. 5:e1000659-e1000659(2009) · Mapped (5) |
| EGFRvIII deletion mutations in pediatric high-grade glioma and response to targeted therapy in pediatric glioma cell lines. Bax D.A., Gaspar N., Little S.E., Marshall L., Perryman L., Regairaz M., Viana-Pereira M., Vuononvirta R., Sharp S.Y., Reis-Filho J.S. et al. Clin. Cancer Res. 15:5753-5761(2009) · Mapped (19) |
| Combining hit identification strategies: fragment-based and in silico approaches to orally active 2-aminothieno[2,3-d]pyrimidine inhibitors of the Hsp90 molecular chaperone. Brough P.A., Barril X., Borgognoni J., Chene P., Davies N.G., Davis B., Drysdale M.J., Dymock B., Eccles S.A., Garcia-Echeverria C. et al. J. Med. Chem. 52:4794-4809(2009) · Mapped (1) |
| Rapid evolution of virulence and drug resistance in the emerging zoonotic pathogen Streptococcus suis. Holden M.T.G., Hauser H., Sanders M., Ngo T.H., Cherevach I., Cronin A., Goodhead I., Mungall K., Quail M.A., Price C. et al. PLoS ONE 4:E6072-E6072(2009) · UniProtKB (5,623) |
| Variants in MTNR1B influence fasting glucose levels. Prokopenko I., Langenberg C., Florez J.C., Saxena R., Soranzo N., Thorleifsson G., Loos R.J., Manning A.K., Jackson A.U., Aulchenko Y. et al. Nat. Genet. 41:77-81(2009) · Mapped (7) |
| Cortical serotonin 1A receptor levels are associated with depression in patients with dementia with Lewy bodies and Parkinson's disease dementia. Sharp S.I., Ballard C.G., Ziabreva I., Piggott M.A., Perry R.H., Perry E.K., Aarsland D., Ehrt U., Larsen J.P., Francis P.T. Dement Geriatr Cogn Disord 26:330-338(2008) · Mapped (4) |
| Pleistocene climatic cycling and diversification of the Andean treefrog, Hypsiboas andinus. Koscinski D., Handford P., Tubaro P.L., Sharp S., Lougheed S.C. Mol. Ecol. 17:2012-2025(2008) · UniProtKB (6) |
| 4,5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer. Brough P.A., Aherne W., Barril X., Borgognoni J., Boxall K., Cansfield J.E., Cheung K.M., Collins I., Davies N.G., Drysdale M.J. et al. J. Med. Chem. 51:196-218(2008) · Mapped (1) |
| Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues. Sharp S.Y., Prodromou C., Boxall K., Powers M.V., Holmes J.L., Box G., Matthews T.P., Cheung K.M., Kalusa A., James K. et al. Mol. Cancer Ther. 6:1198-1211(2007) · Mapped (1) |