| Follicle stimulating hormone receptor mutations and reproductive disorders. Tao Y.X., Segaloff D.L.
Prog Mol Biol Transl Sci 89:115-131(2009) · Mapped (5) |
| Diseases associated with mutations of the human lutropin receptor. Segaloff D.L.
Prog Mol Biol Transl Sci 89:97-114(2009) · Mapped (3) |
| Female mice expressing constitutively active mutants of FSH receptor present with a phenotype of premature follicle depletion and estrogen excess. Peltoketo H., Strauss L., Karjalainen R., Zhang M., Stamp G.W., Segaloff D.L., Poutanen M., Huhtaniemi I.T.
Endocrinology 151:1872-1883(2010) · Mapped (2) |
| A cell surface inactive mutant of the human lutropin receptor (hLHR) attenuates signaling of wild-type or constitutively active receptors via heterodimerization. Zhang M., Feng X., Guan R., Hebert T.E., Segaloff D.L.
Cell. Signal. 21:1663-1671(2009) · Mapped (3) |
| Bioluminescence resonance energy transfer studies reveal constitutive dimerization of the human lutropin receptor and a lack of correlation between receptor activation and the propensity for dimerization. Guan R., Feng X., Wu X., Zhang M., Zhang X., Hebert T.E., Segaloff D.L.
J. Biol. Chem. 284:7483-7494(2009) · Mapped (3) |
| An intracellular loop (IL2) residue confers different basal constitutive activities to the human lutropin receptor and human thyrotropin receptor through structural communication between IL2 and helix 6, via helix 3. Feng X., Muller T., Mizrachi D., Fanelli F., Segaloff D.L.
Endocrinology 149:1705-1717(2008) · Mapped (9) |
| Intrinsic differences in the response of the human lutropin receptor versus the human follitropin receptor to activating mutations. Zhang M., Tao Y.X., Ryan G.L., Feng X., Fanelli F., Segaloff D.L.
J. Biol. Chem. 282:25527-25539(2007) · Mapped (8) |
| Evaluating the roles of follicle-stimulating hormone receptor polymorphisms in gonadal hyperstimulation associated with severe juvenile primary hypothyroidism. Ryan G.L., Feng X., d'Alva C.B., Zhang M., Van Voorhis B.J., Pinto E.M., Kubias A.E., Antonini S.R., Latronico A.C., Segaloff D.L.
J. Clin. Endocrinol. Metab. 92:2312-2317(2007) · Mapped (5) |
| Insights learned from L457(3.43)R, an activating mutant of the human lutropin receptor. Latronico A.C., Segaloff D.L.
Mol. Cell. Endocrinol. 260-262:287-293(2007) · Mapped (3) |
| Functional analyses of melanocortin-4 receptor mutations identified from patients with binge eating disorder and nonobese or obese subjects. Tao Y.X., Segaloff D.L.
J. Clin. Endocrinol. Metab. 90:5632-5638(2005) · Mapped (1) |
| The formation of a salt bridge between helices 3 and 6 is responsible for the constitutive activity and lack of hormone responsiveness of the naturally occurring L457R mutation of the human lutropin receptor. Zhang M., Mizrachi D., Fanelli F., Segaloff D.L.
J. Biol. Chem. 280:26169-26176(2005) · Mapped (3) |
| Functional characterization of melanocortin-3 receptor variants identify a loss-of-function mutation involving an amino acid critical for G protein-coupled receptor activation. Tao Y.-X., Segaloff D.L.
J. Clin. Endocrinol. Metab. 89:3936-3942(2004) · UniProtKB (1) |
| Deletion of codons 88-92 of the melanocortin-4 receptor gene: a novel deleterious mutation in an obese female. Donohoue P.A., Tao Y.-X., Collins M., Yeo G.S.H., O'Rahilly S., Segaloff D.L.
J. Clin. Endocrinol. Metab. 88:5841-5845(2003) · UniProtKB (1) |
| Constitutive and agonist-dependent self-association of the cell surface human lutropin receptor. Tao Y.X., Johnson N.B., Segaloff D.L.
J. Biol. Chem. 279:5904-5914(2004) · Mapped (3) |
| Functional characterization of melanocortin-4 receptor mutations associated with childhood obesity. Tao Y.X., Segaloff D.L.
Endocrinology 144:4544-4551(2003) · Mapped (1) |
| Constitutive activation of the LH receptor is associated with an alteration in the conformation of the ectodomain. Jaquette J., Segaloff D.L.
Mol. Cell. Endocrinol. 194:211-215(2002) · Mapped (3) |
| Chimeras of the rat and human FSH receptors (FSHRs) identify residues that permit or suppress transmembrane 6 mutation-induced constitutive activation of the FSHR via rearrangements of hydrophobic interactions between helices 6 and 7. Tao Y.X., Mizrachi D., Segaloff D.L.
Mol. Endocrinol. 16:1881-1892(2002) · Mapped (6) |
| The lutropin/choriogonadotropin receptor, a 2002 perspective. Ascoli M., Fanelli F., Segaloff D.L.
Endocr. Rev. 23:141-174(2002) · Mapped (3) |
| Gonadotropin-independent precocious puberty due to luteinizing hormone receptor mutations in Brazilian boys: a novel constitutively activating mutation in the first transmembrane helix. Latronico A.C., Shinozaki H., Guerra G. Jr., Pereira M.A.A., Lemos Marini S.H.V., Baptista M.T.M., Arnhold I.J.P., Fanelli F., Mendonca B.B., Segaloff D.L.
J. Clin. Endocrinol. Metab. 85:4799-4805(2000) · UniProtKB (1) |
| A unique constitutively activating mutation in third transmembrane helix of luteinizing hormone receptor causes sporadic male gonadotropin-independent precocious puberty. Latronico A.C., Abell A.N., Arnhold I.J., Liu X., Lins T.S., Brito V.N., Billerbeck A.E., Segaloff D.L., Mendonca B.B.
J. Clin. Endocrinol. Metab. 83:2435-2440(1998) · UniProtKB (1) |
| A homozygous microdeletion in helix 7 of the luteinizing hormone receptor associated with familial testicular and ovarian resistance is due to both decreased cell surface expression and impaired effector activation by the cell surface receptor. Latronico A.C., Chai Y., Arnhold I.J.P., Liu X., Mendonca B.B., Segaloff D.L.
Mol. Endocrinol. 12:442-450(1998) · UniProtKB (1) |
| Identification of the sites of N-linked glycosylation on the follicle-stimulating hormone (FSH) receptor and assessment of their role in FSH receptor function. Davis D., Liu X., Segaloff D.L.
Mol. Endocrinol. 9:159-170(1995) · UniProtKB (1) |
| Lutropin-choriogonadotropin receptor: an unusual member of the G protein-coupled receptor family. McFarland K.C., Sprengel R., Phillips H.S., Koehler M., Rosemblit N., Nikolics K., Segaloff D.L., Seeburg P.H.
Science 245:494-499(1989) · UniProtKB (1) · Mapped (7) |
| Isolation of TSH and LH/CG receptor cDNAs from human thyroid: regulation by tissue specific splicing. Frazier A.L., Robbins L.S., Stork P.J., Sprengel R., Segaloff D.L., Cone R.D.
Mol. Endocrinol. 4:1264-1276(1990) · UniProtKB (2) |
| Structure of the lutropin/choriogonadotropin receptor. Segaloff D.L., Sprengel R., Nikolics K., Ascoli M.
Recent Prog. Horm. Res. 46:261-301(1990) · UniProtKB (1) |
