1 - 25 of 30 results for author:"Sanguinetti M.C." in Literature citations
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| Tuning of EAG K(+) channel inactivation: molecular determinants of amplification by mutations and a small molecule. Garg V., Sachse F.B., Sanguinetti M.C. J. Gen. Physiol. 140:307-324(2012) · Mapped (1) |
| Molecular determinants of human ether-a-go-go-related gene 1 (hERG1) K+ channel activation by NS1643. Grunnet M., Abbruzzese J., Sachse F.B., Sanguinetti M.C. Mol. Pharmacol. 79:1-9(2011) · Mapped (14) |
| Modification of hERG1 channel gating by Cd2+. Abbruzzese J., Sachse F.B., Tristani-Firouzi M., Sanguinetti M.C. J. Gen. Physiol. 136:203-224(2010) · Mapped (14) |
| HERG1 channelopathies. Sanguinetti M.C. Pflugers Arch. 460:265-276(2010) · Mapped (14) |
| PD-118057 contacts the pore helix of hERG1 channels to attenuate inactivation and enhance K+ conductance. Perry M., Sachse F.B., Abbruzzese J., Sanguinetti M.C. Proc. Natl. Acad. Sci. U.S.A. 106:20075-20080(2009) · Mapped (14) |
| A highly conserved alanine in the S6 domain of the hERG1 K+ channel is required for normal gating. Brown S., Sonntag D.P., Sanguinetti M.C. Cell. Physiol. Biochem. 22:601-610(2008) · Mapped (14) |
| Structural determinants of Kvbeta1.3-induced channel inactivation: a hairpin modulated by PIP2. Decher N., Gonzalez T., Streit A.K., Sachse F.B., Renigunta V., Soom M., Heinemann S.H., Daut J., Sanguinetti M.C. EMBO J. 27:3164-3174(2008) · Mapped (5) |
| Molecular determinants of hERG channel block by terfenadine and cisapride. Kamiya K., Niwa R., Morishima M., Honjo H., Sanguinetti M.C. J. Pharmacol. Sci. 108:301-307(2008) · Mapped (14) |
| Cooperative interactions between R531 and acidic residues in the voltage sensing module of hERG1 channels. Piper D.R., Rupp J., Sachse F.B., Sanguinetti M.C., Tristani-Firouzi M. Cell. Physiol. Biochem. 21:37-46(2008) · Mapped (14) |
| A single amino acid difference between ether-a-go-go- related gene channel subtypes determines differential sensitivity to a small molecule activator. Perry M., Sanguinetti M.C. Mol. Pharmacol. 73:1044-1051(2008) · Mapped (14) |
| Structural basis of action for a human ether-a-go-go-related gene 1 potassium channel activator. Perry M., Sachse F.B., Sanguinetti M.C. Proc. Natl. Acad. Sci. U.S.A. 104:13827-13832(2007) · Mapped (14) |
| Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death. Antzelevitch C., Pollevick G.D., Cordeiro J.M., Casis O., Sanguinetti M.C., Aizawa Y., Guerchicoff A., Pfeiffer R., Oliva A., Wollnik B. et al. |
| Molecular determinants of HERG channel block. Kamiya K., Niwa R., Mitcheson J.S., Sanguinetti M.C. Mol. Pharmacol. 69:1709-1716(2006) · Mapped (14) |
| Severe arrhythmia disorder caused by cardiac L-type calcium channel mutations. Splawski I., Timothy K.W., Decher N., Kumar P., Sachse F.B., Beggs A.H., Sanguinetti M.C., Keating M.T. Proc. Natl. Acad. Sci. U.S.A. 102:8089-8096(2005) · UniProtKB (1) · Mapped (20) |
| Regional specificity of human ether-a'-go-go-related gene channel activation and inactivation gating. Piper D.R., Hinz W.A., Tallurri C.K., Sanguinetti M.C., Tristani-Firouzi M. J. Biol. Chem. 280:7206-7217(2005) · Mapped (14) |
| Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism. Splawski I., Timothy K.W., Sharpe L.M., Decher N., Kumar P., Bloise R., Napolitano C., Schwartz P.J., Joseph R.M., Condouris K. et al. |
| Compound mutations: a common cause of severe long-QT syndrome. Westenskow P., Splawski I., Timothy K.W., Keating M.T., Sanguinetti M.C. Circulation 109:1834-1841(2004) · UniProtKB (2) · Mapped (35) |
| Voltage-dependent gating of hyperpolarization-activated, cyclic nucleotide-gated pacemaker channels: molecular coupling between the S4-S5 and C-linkers. Decher N., Chen J., Sanguinetti M.C. J. Biol. Chem. 279:13859-13865(2004) · Mapped (2) |
| Molecular basis for Kv1.5 channel block: conservation of drug binding sites among voltage-gated K+ channels. Decher N., Pirard B., Bundis F., Peukert S., Baringhaus K.H., Busch A.E., Steinmeyer K., Sanguinetti M.C. J. Biol. Chem. 279:394-400(2004) · Mapped (1) |
| KCNQ2 and KCNQ3 potassium channel genes in benign familial neonatal convulsions: expansion of the functional and mutation spectrum. The BFNC physician consortium Brain 126:2726-2737(2003) · UniProtKB (2) |
| Voltage-dependent profile of human ether-a-go-go-related gene channel block is influenced by a single residue in the S6 transmembrane domain. Sanchez-Chapula J.A., Ferrer T., Navarro-Polanco R.A., Sanguinetti M.C. Mol. Pharmacol. 63:1051-1058(2003) · Mapped (14) |
| Position of aromatic residues in the S6 domain, not inactivation, dictates cisapride sensitivity of HERG and eag potassium channels. Chen J., Seebohm G., Sanguinetti M.C. Proc. Natl. Acad. Sci. U.S.A. 99:12461-12466(2002) · Mapped (16) |
| The S4-S5 linker couples voltage sensing and activation of pacemaker channels. Chen J., Mitcheson J.S., Tristani-Firouzi M., Lin M., Sanguinetti M.C. Proc. Natl. Acad. Sci. U.S.A. 98:11277-11282(2001) · UniProtKB (1) |
| Functional roles of charged residues in the putative voltage sensor of the HCN2 pacemaker channel. Chen J., Mitcheson J.S., Lin M., Sanguinetti M.C. J. Biol. Chem. 275:36465-36471(2000) · UniProtKB (1) |
| Long QT syndrome-associated mutations in the S4-S5 linker of KvLQT1 potassium channels modify gating and interaction with minK subunits. Franqueza L., Lin M., Shen J., Keating M.T., Sanguinetti M.C. J. Biol. Chem. 274:21063-21070(1999) · UniProtKB (1) |