1 - 25 of 57 results for author:"Samuelsson B." in Literature citations
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| Highly potent macrocyclic BACE-1 inhibitors incorporating a hydroxyethylamine core: design, synthesis and X-ray crystal structures of enzyme inhibitor complexes. Sandgren V., Agback T., Johansson P.O., Lindberg J., Kvarnstrom I., Samuelsson B., Belda O., Dahlgren A. Bioorg. Med. Chem. 20:4377-4389(2012) · Mapped (1) |
| Synthesis, X-ray analysis, and biological evaluation of a new class of stereopure lactam-based HIV-1 protease inhibitors. Wu X., Ohrngren P., Joshi A.A., Trejos A., Persson M., Arvela R.K., Wallberg H., Vrang L., Rosenquist A., Samuelsson B.B. et al. J. Med. Chem. 55:2724-2736(2012) · Mapped (1) |
| Targeted knock-down of a structurally atypical zebrafish 12S-lipoxygenase leads to severe impairment of embryonic development. Haas U., Raschperger E., Hamberg M., Samuelsson B., Tryggvason K., Haeggstrom J.Z. Proc. Natl. Acad. Sci. U.S.A. 108:20479-20484(2011) · Mapped (1) |
| Design and synthesis of potent macrocyclic renin inhibitors. Sund C., Belda O., Wiktelius D., Sahlberg C., Vrang L., Sedig S., Hamelink E., Henderson I., Agback T., Jansson K. et al. Bioorg. Med. Chem. Lett. 21:358-362(2011) · Mapped (1) |
| Increased expression of leukotriene C4 synthase and predominant formation of cysteinyl-leukotrienes in human abdominal aortic aneurysm. Di Gennaro A., Wagsater D., Mayranpaa M.I., Gabrielsen A., Swedenborg J., Hamsten A., Samuelsson B., Eriksson P., Haeggstrom J.Z. Proc. Natl. Acad. Sci. U.S.A. 107:21093-21097(2010) · Mapped (2) |
| Induced-fit binding of the macrocyclic noncovalent inhibitor TMC435 to its HCV NS3/NS4A protease target. Cummings M.D., Lindberg J., Lin T.I., de Kock H., Lenz O., Lilja E., Fellander S., Baraznenok V., Nystrom S., Nilsson M. et al. Angew. Chem. Int. Ed. Engl. 49:1652-1655(2010) · UniProtKB (3) |
| Design and synthesis of potent and selective BACE-1 inhibitors. Bjorklund C., Oscarson S., Benkestock K., Borkakoti N., Jansson K., Lindberg J., Vrang L., Hallberg A., Rosenquist A., Samuelsson B. J. Med. Chem. 53:1458-1464(2010) · Mapped (1) |
| Discovery of potent BACE-1 inhibitors containing a new hydroxyethylene (HE) scaffold: exploration of P1' alkoxy residues and an aminoethylene (AE) central core. Bjorklund C., Adolfsson H., Jansson K., Lindberg J., Vrang L., Hallberg A., Rosenquist S., Samuelsson B. Bioorg. Med. Chem. 18:1711-1723(2010) · Mapped (1) |
| Synthesis of potent BACE-1 inhibitors incorporating a hydroxyethylene isostere as central core. Wangsell F., Gustafsson K., Kvarnstrom I., Borkakoti N., Edlund M., Jansson K., Lindberg J., Hallberg A., Rosenquist A., Samuelsson B. Eur J Med Chem 45:870-882(2010) · Mapped (1) |
| HIV-1 protease inhibitors with a transition-state mimic comprising a tertiary alcohol: improved antiviral activity in cells. Mahalingam A.K., Axelsson L., Ekegren J.K., Wannberg J., Kihlstrom J., Unge T., Wallberg H., Samuelsson B., Larhed M., Hallberg A. J. Med. Chem. 53:607-615(2010) · Mapped (1) |
| Coactosin-like protein functions as a stabilizing chaperone for 5-lipoxygenase: role of tryptophan 102. Esser J., Rakonjac M., Hofmann B., Fischer L., Provost P., Schneider G., Steinhilber D., Samuelsson B., Radmark O. |
| Human Dicer C-terminus functions as a 5-lipoxygenase binding domain. Dincbas-Renqvist V., Pepin G., Rakonjac M., Plante I., Ouellet D.L., Hermansson A., Goulet I., Doucet J., Samuelsson B., Radmark O. et al. Biochim. Biophys. Acta 1789:99-108(2009) · Mapped (13) |
| Design, synthesis and SAR of potent statine-based BACE-1 inhibitors: exploration of P1 phenoxy and benzyloxy residues. Back M., Nyhlen J., Kvarnstrom I., Appelgren S., Borkakoti N., Jansson K., Lindberg J., Nystrom S., Hallberg A., Rosenquist S. et al. Bioorg. Med. Chem. 16:9471-9486(2008) · Mapped (1) |
| Two-carbon-elongated HIV-1 protease inhibitors with a tertiary-alcohol-containing transition-state mimic. Wu X., Ohrngren P., Ekegren J.K., Unge J., Unge T., Wallberg H., Samuelsson B., Hallberg A., Larhed M. J. Med. Chem. 51:1053-1057(2008) · Mapped (1) |
| Coactosin-like protein supports 5-lipoxygenase enzyme activity and up-regulates leukotriene A4 production. Rakonjac M., Fischer L., Provost P., Werz O., Steinhilber D., Samuelsson B., Radmark O. Proc. Natl. Acad. Sci. U.S.A. 103:13150-13155(2006) · Mapped (8) |
| Expression of 5-lipoxygenase and leukotriene A4 hydrolase in human atherosclerotic lesions correlates with symptoms of plaque instability. Qiu H., Gabrielsen A., Agardh H.E., Wan M., Wetterholm A., Wong C.H., Hedin U., Swedenborg J., Hansson G.K., Samuelsson B. et al. Proc. Natl. Acad. Sci. U.S.A. 103:8161-8166(2006) · Mapped (24) |
| Microwave-accelerated synthesis of P1'-extended HIV-1 protease inhibitors encompassing a tertiary alcohol in the transition-state mimicking scaffold. Ekegren J.K., Ginman N., Johansson A., Wallberg H., Larhed M., Samuelsson B., Unge T., Hallberg A. J. Med. Chem. 49:1828-1832(2006) · UniProtKB (1) |
| GC-rich sequences in the 5-lipoxygenase gene promoter are required for expression in Mono Mac 6 cells, characterization of a novel Sp1 binding site. Dishart D., Schnur N., Klan N., Werz O., Steinhilber D., Samuelsson B., Radmark O. Biochim. Biophys. Acta 1738:37-47(2005) · Mapped (14) |
| A new class of HIV-1 protease inhibitors containing a tertiary alcohol in the transition-state mimicking scaffold. Ekegren J.K., Unge T., Safa M.Z., Wallberg H., Samuelsson B., Hallberg A. J. Med. Chem. 48:8098-8102(2005) · UniProtKB (1) |
| Caspase-mediated degradation of human 5-lipoxygenase in B lymphocytic cells. Werz O., Tretiakova I., Michel A., Ulke-Lemee A., Hornig M., Franke L., Schneider G., Samuelsson B., Radmark O., Steinhilber D. Proc. Natl. Acad. Sci. U.S.A. 102:13164-13169(2005) · Mapped (8) |
| Mutation analysis of the human 5-lipoxygenase C-terminus: support for a stabilizing C-terminal loop. Okamoto H., Hammarberg T., Zhang Y.Y., Persson B., Watanabe T., Samuelsson B., Radmark O. Biochim. Biophys. Acta 1749:123-131(2005) · Mapped (7) |
| NMR structure of human coactosin-like protein. Liepinsh E., Rakonjac M., Boissonneault V., Provost P., Samuelsson B., Radmark O., Otting G. J. Biomol. NMR 30:353-356(2004) · UniProtKB (1) · Mapped (1) |
| Symmetric fluoro-substituted diol-based HIV protease inhibitors. Ortho-fluorinated and meta-fluorinated P1/P1'-benzyloxy side groups significantly improve the antiviral activity and preserve binding efficacy. Lindberg J., Pyring D., Lowgren S., Rosenquist A., Zuccarello G., Kvarnstrom I., Zhang H., Vrang L., Classon B., Hallberg A. et al. Eur. J. Biochem. 271:4594-4602(2004) · UniProtKB (1) |
| 5-Lipoxygenase activation by MAPKAPK-2 and ERKs. Werz O., Burkert E., Fischer L., Szellas D., Dishart D., Samuelsson B., Radmark O., Steinhilber D. Adv. Exp. Med. Biol. 525:129-132(2003) · Mapped (1) |
| Optimization of P1-P3 groups in symmetric and asymmetric HIV-1 protease inhibitors. Andersson H.O., Fridborg K., Lowgren S., Alterman M., Muhlman A., Bjorsne M., Garg N., Kvarnstrom I., Schaal W., Classon B. et al. Eur. J. Biochem. 270:1746-1758(2003) · UniProtKB (1) |