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Indispensable role of the Runx1-Cbfbeta transcription complex for in vivo-suppressive function of FoxP3+ regulatory T cells.

Kitoh A., Ono M., Naoe Y., Ohkura N., Yamaguchi T., Yaguchi H., Kitabayashi I., Tsukada T., Nomura T., Miyachi Y. et al.

Immunity 31:609-620(2009) · Mapped (2)

CD4+CD25-LAG3+ regulatory T cells controlled by the transcription factor Egr-2.

Okamura T., Fujio K., Shibuya M., Sumitomo S., Shoda H., Sakaguchi S., Yamamoto K.

Proc. Natl. Acad. Sci. U.S.A. 106:13974-13979(2009) · Mapped (9)

Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor.

Miyara M., Yoshioka Y., Kitoh A., Shima T., Wing K., Niwa A., Parizot C., Taflin C., Heike T., Valeyre D. et al.

Immunity 30:899-911(2009) · Mapped (5)

Antagonistic roles of the N-terminal domain of prion protein to doppel.

Sakaguchi S.

Prion 2:107-111(2008) · Mapped (2)

The presence of Foxp3 expressing T cells within grafts of tolerant human liver transplant recipients.

Li Y., Zhao X., Cheng D., Haga H., Tsuruyama T., Wood K., Sakaguchi S., Tanaka K., Uemoto S., Koshiba T.

Transplantation 86:1837-1843(2008) · Mapped (5)

A critical link between Toll-like receptor 3 and type II interferon signaling pathways in antiviral innate immunity.

Negishi H., Osawa T., Ogami K., Ouyang X., Sakaguchi S., Koshiba R., Yanai H., Seko Y., Shitara H., Bishop K. et al.

Proc. Natl. Acad. Sci. U.S.A. 105:20446-20451(2008) · Mapped (17)

Impaired T-cell development in the absence of Vav1 and Itk.

Raberger J., Boucheron N., Sakaguchi S., Penninger J.M., Ellmeier W.

Eur. J. Immunol. 38:3530-3542(2008) · Mapped (25)

The transcriptional regulator PLZF induces the development of CD44 high memory phenotype T cells.

Raberger J., Schebesta A., Sakaguchi S., Boucheron N., Blomberg K.E., Berglof A., Kolbe T., Smith C.I., Rulicke T., Ellmeier W.

Proc. Natl. Acad. Sci. U.S.A. 105:17919-17924(2008) · Mapped (15)

CTLA-4 control over Foxp3+ regulatory T cell function.

Wing K., Onishi Y., Prieto-Martin P., Yamaguchi T., Miyara M., Fehervari Z., Nomura T., Sakaguchi S.

Science 322:271-275(2008) · Mapped (7)

Arthritis and pneumonitis produced by the same T cell clones from mice with spontaneous autoimmune arthritis.

Wakasa-Morimoto C., Toyosaki-Maeda T., Matsutani T., Yoshida R., Nakamura-Kikuoka S., Maeda-Tanimura M., Yoshitomi H., Hirota K., Hashimoto M., Masaki H. et al.

Int. Immunol. 20:1331-1342(2008) · Mapped (1)

Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation.

Onishi Y., Fehervari Z., Yamaguchi T., Sakaguchi S.

Proc. Natl. Acad. Sci. U.S.A. 105:10113-10118(2008) · Mapped (15)

Dominant-negative effects of the N-terminal half of prion protein on neurotoxicity of prion protein-like protein/doppel in mice.

Yoshikawa D., Yamaguchi N., Ishibashi D., Yamanaka H., Okimura N., Yamaguchi Y., Mori T., Miyata H., Shigematsu K., Katamine S. et al.

J. Biol. Chem. 283:24202-24211(2008) · Mapped (7)

Molecular and clinical characterization in Japanese and Korean patients with Hailey-Hailey disease: six new mutations in the ATP2C1 gene.

Hamada T., Fukuda S., Sakaguchi S., Yasumoto S., Kim S.C., Hashimoto T.

J. Dermatol. Sci. 51:31-36(2008) · Mapped (6)

Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals.

Shinohara M., Koga T., Okamoto K., Sakaguchi S., Arai K., Yasuda H., Takai T., Kodama T., Morio T., Geha R.S. et al.

Cell 132:794-806(2008) · Mapped (15)

Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model.

Hirota K., Yoshitomi H., Hashimoto M., Maeda S., Teradaira S., Sugimoto N., Yamaguchi T., Nomura T., Ito H., Nakamura T. et al.

J. Exp. Med. 204:2803-2812(2007) · Mapped (3)

Control of immune responses by antigen-specific regulatory T cells expressing the folate receptor.

Yamaguchi T., Hirota K., Nagahama K., Ohkawa K., Takahashi T., Nomura T., Sakaguchi S.

Immunity 27:145-159(2007) · Mapped (5)

Late-onset olfactory deficits and mitral cell loss in mice lacking prion protein with ectopic expression of Doppel.

Kim C.K., Sakudo A., Taniuchi Y., Shigematsu K., Kang C.B., Saeki K., Matsumoto Y., Sakaguchi S., Itohara S., Onodera T.

Int. J. Mol. Med. 20:169-176(2007) · Mapped (10)

Doppel induces degeneration of cerebellar Purkinje cells independently of Bax.

Dong J., Li A., Yamaguchi N., Sakaguchi S., Harris D.A.

Am. J. Pathol. 171:599-607(2007) · Mapped (12)

Reduced response of splenocytes after mitogen-stimulation in the prion protein (PrP) gene-deficient mouse: PrPLP/Doppel production and cerebral degeneration.

Kim C.K., Hirose Y., Sakudo A., Takeyama N., Kang C.B., Taniuchi Y., Matsumoto Y., Itohara S., Sakaguchi S., Onodera T.

Biochem. Biophys. Res. Commun. 358:469-474(2007) · Mapped (2)

Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1.

Ono M., Yaguchi H., Ohkura N., Kitabayashi I., Nagamura Y., Nomura T., Miyachi Y., Tsukada T., Sakaguchi S.

Nature 446:685-689(2007) · Mapped (11)

ICER/CREM-mediated transcriptional attenuation of IL-2 and its role in suppression by regulatory T cells.

Bodor J., Fehervari Z., Diamond B., Sakaguchi S.

Eur. J. Immunol. 37:884-895(2007) · Mapped (11)

T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis.

Hirota K., Hashimoto M., Yoshitomi H., Tanaka S., Nomura T., Yamaguchi T., Iwakura Y., Sakaguchi N., Sakaguchi S.

J. Exp. Med. 204:41-47(2007) · Mapped (21)

Immunohistochemical characterization of cell types expressing the cellular prion protein in the small intestine of cattle and mice.

Miyazawa K., Kanaya T., Tanaka S., Takakura I., Watanabe K., Ohwada S., Kitazawa H., Rose M.T., Sakaguchi S., Katamine S. et al.

Histochem. Cell Biol. 127:291-301(2007) · Mapped (8)

A role for Dicer in immune regulation.

Cobb B.S., Hertweck A., Smith J., O'Connor E., Graf D., Cook T., Smale S.T., Sakaguchi S., Livesey F.J., Fisher A.G. et al.

J. Exp. Med. 203:2519-2527(2006) · Mapped (14)

Newly established in vitro system with fluorescent proteins shows that abnormal expression of downstream prion protein-like protein in mice is probably due to functional disconnection between splicing and 3' formation of prion protein pre-mRNA.

Yoshikawa D., Kopacek J., Yamaguchi N., Ishibashi D., Yamanaka H., Yamaguchi Y., Katamine S., Sakaguchi S.

Gene 386:139-146(2007) · Mapped (2)

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