| Reconstruction of nuclear receptor network reveals that NR2E3 is a novel upstream regulator of ESR1 in breast cancer. Park Y.Y., Kim K., Kim S.B., Hennessy B.T., Kim S.M., Park E.S., Lim J.Y., Li J., Lu Y., Gonzalez-Angulo A.M. et al.
EMBO Mol Med 4:52-67(2012) · Mapped (63) |
| The nuclear receptor TR3 regulates mTORC1 signaling in lung cancer cells expressing wild-type p53. Lee S.O., Andey T., Jin U.H., Kim K., Singh M., Sachdeva M., Safe S.
Oncogene 31:3265-3276(2012) · Mapped (32) |
| PAH particles perturb prenatal processes and phenotypes: protection from deficits in object discrimination afforded by dampening of brain oxidoreductase following in utero exposure to inhaled benzo(a)pyrene. Li Z., Chadalapaka G., Ramesh A., Khoshbouei H., Maguire M., Safe S., Rhoades R.E., Clark R., Jules G., McCallister M. et al.
Toxicol. Sci. 125:233-247(2012) · Mapped (6) |
| Pharmacologic doses of ascorbic acid repress specificity protein (Sp) transcription factors and Sp-regulated genes in colon cancer cells. Pathi S.S., Lei P., Sreevalsan S., Chadalapaka G., Jutooru I., Safe S.
Nutr Cancer 63:1133-1142(2011) · Mapped (17) |
| Identification of oncogenic microRNA-17-92/ZBTB4/specificity protein axis in breast cancer. Kim K., Chadalapaka G., Lee S.O., Yamada D., Sastre-Garau X., Defossez P.A., Park Y.Y., Lee J.S., Safe S.
Oncogene 31:1034-1044(2012) · Mapped (3) |
| Inhibition of NFkappaB and pancreatic cancer cell and tumor growth by curcumin is dependent on specificity protein down-regulation. Jutooru I., Chadalapaka G., Lei P., Safe S.
J. Biol. Chem. 285:25332-25344(2010) · Mapped (24) |
| MicroRNA-27a Indirectly Regulates Estrogen Receptor {alpha} Expression and Hormone Responsiveness in MCF-7 Breast Cancer Cells. Li X., Mertens-Talcott S.U., Zhang S., Kim K., Ball J., Safe S.
Endocrinology 151:2462-2473(2010) · Mapped (61) |
| Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease. da Costa C.A., Sunyach C., Giaime E., West A., Corti O., Brice A., Safe S., Abou-Sleiman P.M., Wood N.W., Takahashi H. et al.
Nat. Cell Biol. 11:1370-1375(2009) · Mapped (17) |
| 1,1-Bis(3'-indolyl)-1-(p-bromophenyl)methane and related compounds repress survivin and decrease gamma-radiation-induced survivin in colon and pancreatic cancer cells. Sreevalsan S., Jutooru I., Chadalapaka G., Walker M., Safe S.
Int. J. Oncol. 35:1191-1199(2009) · Mapped (9) |
| The aryl hydrocarbon receptor as a target for estrogen receptor-negative breast cancer chemotherapy. Zhang S., Lei P., Liu X., Li X., Walker K., Kotha L., Rowlands C., Safe S.
Endocr. Relat. Cancer 16:835-844(2009) · Mapped (1) |
| Tolfenamic acid enhances pancreatic cancer cell and tumor response to radiation therapy by inhibiting survivin protein expression. Konduri S., Colon J., Baker C.H., Safe S., Abbruzzese J.L., Abudayyeh A., Basha M.R., Abdelrahim M.
Mol. Cancer Ther. 8:533-542(2009) · Mapped (9) |
| Induction of apoptosis and nonsteroidal anti-inflammatory drug-activated gene 1 in pancreatic cancer cells by a glycyrrhetinic acid derivative. Jutooru I., Chadalapaka G., Chintharlapalli S., Papineni S., Safe S.
Mol. Carcinog. 48:692-702(2009) · Mapped (1) |
| 1,1-Bis(3'-indolyl)-1-(p-chlorophenyl)methane activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth. Inamoto T., Papineni S., Chintharlapalli S., Cho S.D., Safe S., Kamat A.M.
Mol. Cancer Ther. 7:3825-3833(2008) · Mapped (3) |
| ESE-1/EGR-1 pathway plays a role in tolfenamic acid-induced apoptosis in colorectal cancer cells. Lee S.H., Bahn J.H., Choi C.K., Whitlock N.C., English A.E., Safe S., Baek S.J.
Mol. Cancer Ther. 7:3739-3750(2008) · Mapped (6) |
| Curcumin decreases specificity protein expression in bladder cancer cells. Chadalapaka G., Jutooru I., Chintharlapalli S., Papineni S., Smith R., Li X., Safe S.
Cancer Res. 68:5345-5354(2008) · Mapped (17) |
| The peroxisome proliferator-activated receptor-gamma agonist 1,1-bis(3'-indolyl)-1-(p-trifluoromethylphenyl)methane suppresses manganese-induced production of nitric oxide in astrocytes and inhibits apoptosis in cocultured PC12 cells. Tjalkens R.B., Liu X., Mohl B., Wright T., Moreno J.A., Carbone D.L., Safe S.
J. Neurosci. Res. 86:618-629(2008) · Mapped (1) |
| Structure-dependent activity of glycyrrhetinic acid derivatives as peroxisome proliferator-activated receptor {gamma} agonists in colon cancer cells. Chintharlapalli S., Papineni S., Jutooru I., McAlees A., Safe S.
Mol. Cancer Ther. 6:1588-1598(2007) · Mapped (9) |
| Coactivation of estrogen receptor alpha (ER alpha)/Sp1 by vitamin D receptor interacting protein 150 (DRIP150). Lee J., Safe S.
Arch. Biochem. Biophys. 461:200-210(2007) · Mapped (2) |
| Regulation of vascular endothelial growth factor receptor-2 expression in pancreatic cancer cells by Sp proteins. Higgins K.J., Abdelrahim M., Liu S., Yoon K., Safe S.
Biochem. Biophys. Res. Commun. 345:292-301(2006) · Mapped (3) |
| Molecular mechanism of inhibitory aryl hydrocarbon receptor-estrogen receptor/Sp1 cross talk in breast cancer cells. Khan S., Barhoumi R., Burghardt R., Liu S., Kim K., Safe S.
Mol. Endocrinol. 20:2199-2214(2006) · Mapped (66) |
| 17beta-estradiol (E2) induces cdc25A gene expression in breast cancer cells by genomic and non-genomic pathways. Ru Lee W., Chen C.C., Liu S., Safe S.
J. Cell. Biochem. 99:209-220(2006) · Mapped (3) |
| Vascular endothelial growth factor receptor-2 expression is induced by 17beta-estradiol in ZR-75 breast cancer cells by estrogen receptor alpha/Sp proteins. Higgins K.J., Liu S., Abdelrahim M., Yoon K., Vanderlaag K., Porter W., Metz R.P., Safe S.
Endocrinology 147:3285-3295(2006) · Mapped (71) |
| 3-Methylcholanthrene and other aryl hydrocarbon receptor agonists directly activate estrogen receptor alpha. Abdelrahim M., Ariazi E., Kim K., Khan S., Barhoumi R., Burghardt R., Liu S., Hill D., Finnell R., Wlodarczyk B. et al.
Cancer Res. 66:2459-2467(2006) · Mapped (14) |
| Conjugated linoleic acid stimulates an anti-tumorigenic protein NAG-1 in an isomer specific manner. Lee S.H., Yamaguchi K., Kim J.S., Eling T.E., Safe S., Park Y., Baek S.J.
Carcinogenesis 27:972-981(2006) · Mapped (1) |
| Regulation of KiSS-1 metastasis suppressor gene expression in breast cancer cells by direct interaction of transcription factors activator protein-2alpha and specificity protein-1. Mitchell D.C., Abdelrahim M., Weng J., Stafford L.J., Safe S., Bar-Eli M., Liu M.
J. Biol. Chem. 281:51-58(2006) · Mapped (8) |
