| The B subunits of Shiga-like toxins induce regulated VWF secretion in a phospholipase D1-dependent manner. Huang J., Haberichter S.L., Sadler J.E.
Blood 120:1143-1149(2012) · Mapped (8) |
| Rearranging exosites in noncatalytic domains can redirect the substrate specificity of ADAMTS proteases. Gao W., Zhu J., Westfield L.A., Tuley E.A., Anderson P.J., Sadler J.E.
J. Biol. Chem. 287:26944-26952(2012) · Mapped (1) |
| Phylogenetic and functional analysis of histidine residues essential for pH-dependent multimerization of von Willebrand factor. Dang L.T., Purvis A.R., Huang R.H., Westfield L.A., Sadler J.E.
J. Biol. Chem. 286:25763-25769(2011) · UniProtKB (24) · Mapped (6) |
| Shiga toxin B subunits induce VWF secretion by human endothelial cells and thrombotic microangiopathy in ADAMTS13-deficient mice. Huang J., Motto D.G., Bundle D.R., Sadler J.E.
Blood 116:3653-3659(2010) · Mapped (3) |
| A structural explanation for the antithrombotic activity of ARC1172, a DNA aptamer that binds von Willebrand factor domain A1. Huang R.H., Fremont D.H., Diener J.L., Schaub R.G., Sadler J.E.
Structure 17:1476-1484(2009) · Mapped (1) |
| Multi-step binding of ADAMTS-13 to von Willebrand factor. Feys H.B., Anderson P.J., Vanhoorelbeke K., Majerus E.M., Sadler J.E.
J. Thromb. Haemost. 7:2088-2095(2009) · Mapped (6) |
| von Willebrand factor assembly and secretion. Sadler J.E.
J. Thromb. Haemost. 7 Suppl 1:24-27(2009) · Mapped (6) |
| Integrin alpha(v)beta(3) on human endothelial cells binds von Willebrand factor strings under fluid shear stress. Huang J., Roth R., Heuser J.E., Sadler J.E.
Blood 113:1589-1597(2009) · Mapped (11) |
| Platelet-VWF complexes are preferred substrates of ADAMTS13 under fluid shear stress. Shim K., Anderson P.J., Tuley E.A., Wiswall E., Sadler J.E.
Blood 111:651-657(2008) · Mapped (6) |
| Exosite interactions contribute to tension-induced cleavage of von Willebrand factor by the antithrombotic ADAMTS13 metalloprotease. Gao W., Anderson P.J., Majerus E.M., Tuley E.A., Sadler J.E.
Proc. Natl. Acad. Sci. U.S.A. 103:19099-19104(2006) · Mapped (6) |
| Zinc and calcium ions cooperatively modulate ADAMTS13 activity. Anderson P.J., Kokame K., Sadler J.E.
J. Biol. Chem. 281:850-857(2006) · UniProtKB (1) · Mapped (6) |
| von Willebrand factor: two sides of a coin. Sadler J.E.
J. Thromb. Haemost. 3:1702-1709(2005) · Mapped (6) |
| Binding of ADAMTS13 to von Willebrand factor. Majerus E.M., Anderson P.J., Sadler J.E.
J. Biol. Chem. 280:21773-21778(2005) · Mapped (6) |
| Binding of platelet glycoprotein Ibalpha to von Willebrand factor domain A1 stimulates the cleavage of the adjacent domain A2 by ADAMTS13. Nishio K., Anderson P.J., Zheng X.L., Sadler J.E.
Proc. Natl. Acad. Sci. U.S.A. 101:10578-10583(2004) · Mapped (13) |
| A recombinant murine meizothrombin precursor, prothrombin R157A/R268A, inhibits thrombosis in a model of acute carotid artery injury. Shim K., Zhu H., Westfield L.A., Sadler J.E.
Blood 104:415-419(2004) · Mapped (3) |
| Cleavage of the ADAMTS13 propeptide is not required for protease activity. Majerus E.M., Zheng X., Tuley E.A., Sadler J.E.
J. Biol. Chem. 278:46643-46648(2003) · UniProtKB (1) |
| Crystal structure of von Willebrand factor A1 domain complexed with snake venom, bitiscetin: insight into glycoprotein Ibalpha binding mechanism induced by snake venom proteins. Maita N., Nishio K., Nishimoto E., Matsui T., Shikamoto Y., Morita T., Sadler J.E., Mizuno H.
J. Biol. Chem. 278:37777-37781(2003) · UniProtKB (2) · Mapped (1) |
| Cleavage of von Willebrand factor requires the spacer domain of the metalloprotease ADAMTS13. Zheng X., Nishio K., Majerus E.M., Sadler J.E.
J. Biol. Chem. 278:30136-30141(2003) · UniProtKB (1) |
| Identification of the regulatory elements of the human von Willebrand factor for binding to platelet GPIb. Importance of structural integrity of the regions flanked by the CYS1272-CYS1458 disulfide bond. Nakayama T., Matsushita T., Dong Z., Sadler J.E., Jorieux S., Mazurier C., Meyer D., Kojima T., Saito H.
J. Biol. Chem. 277:22063-22072(2002) · Mapped (13) |
| Mutations in the proenteropeptidase gene are the molecular cause of congenital enteropeptidase deficiency. Holzinger A., Maier E.M., Buck C., Mayerhofer P.U., Kappler M., Haworth J.C., Moroz S.P., Hadorn H.-B., Sadler J.E., Roscher A.A.
Am. J. Hum. Genet. 70:20-25(2002) · UniProtKB (1) · Mapped (1) |
| Type 1 von Willebrand disease mutation Cys1149Arg causes intracellular retention and degradation of heterodimers: a possible general mechanism for dominant mutations of oligomeric proteins. Bodo I., Katsumi A., Tuley E.A., Eikenboom J.C., Dong Z., Sadler J.E.
Blood 98:2973-2979(2001) · UniProtKB (1) |
| Structure of von Willebrand factor-cleaving protease (ADAMTS13), a metalloprotease involved in thrombotic thrombocytopenic purpura. Zheng X., Chung D., Takayama T.K., Majerus E.M., Sadler J.E., Fujikawa K.
J. Biol. Chem. 276:41059-41063(2001) · UniProtKB (1) |
| Crystal structure of the human alpha-thrombin-haemadin complex: an exosite II-binding inhibitor. Richardson J.L., Kroger B., Hoeffken W., Sadler J.E., Pereira P., Huber R., Bode W., Fuentes-Prior P.
EMBO J. 19:5650-5660(2000) · UniProtKB (1) · Mapped (1) |
| Structure of the Ser195Ala mutant of human alpha--thrombin complexed with fibrinopeptide A(7--16): evidence for residual catalytic activity. Krishnan R., Sadler J.E., Tulinsky A.
Acta Crystallogr. D Biol. Crystallogr. 56:406-410(2000) · Mapped (2) |
| Crystal structure of enteropeptidase light chain complexed with an analog of the trypsinogen activation peptide. Lu D., Futterer K., Korolev S., Zheng X., Tan K., Waksman G., Sadler J.E.
J. Mol. Biol. 292:361-373(1999) · Mapped (1) |
