| Severe methylenetetrahydrofolate reductase deficiency in mice results in behavioral anomalies with morphological and biochemical changes in hippocampus. Jadavji N.M., Deng L., Leclerc D., Malysheva O., Bedell B.J., Caudill M.A., Rozen R.
Mol. Genet. Metab. 106:149-159(2012) · Mapped (13) |
| Dysregulation of gene expression in a lysosomal storage disease varies between brain regions implicating unexpected mechanisms of neuropathology. Parente M.K., Rozen R., Cearley C.N., Wolfe J.H.
PLoS ONE 7:e32419-e32419(2012) · Mapped (6) |
| Disturbed one-carbon metabolism causing adverse reproductive outcomes in mice is associated with altered expression of apolipoprotein AI and inflammatory mediators PPARalpha, interferon-gamma, and interleukin-10. Mikael L.G., Pancer J., Wu Q., Rozen R.
J. Nutr. 142:411-418(2012) · Mapped (22) |
| Targeted insertion of two Mthfr promoters in mice reveals temporal- and tissue-specific regulation. Pickell L., Wu Q., Wang X.L., Leclerc D., Friedman H., Peterson A.C., Rozen R.
Mamm. Genome 22:635-647(2011) · Mapped (14) |
| A novel transgenic mouse model of CBS-deficient homocystinuria does not incur hepatic steatosis or fibrosis and exhibits a hypercoagulative phenotype that is ameliorated by betaine treatment. Maclean K.N., Sikora J., Kozich V., Jiang H., Greiner L.S., Kraus E., Krijt J., Overdier K.H., Collard R., Brodsky G.L. et al.
Mol. Genet. Metab. 101:153-162(2010) · Mapped (23) |
| Complete deficiency of methylenetetrahydrofolate reductase in mice is associated with impaired retinal function and variable mortality, hematological profiles, and reproductive outcomes. Lawrance A.K., Racine J., Deng L., Wang X., Lachapelle P., Rozen R.
J. Inherit. Metab. Dis. 34:147-157(2011) · Mapped (11) |
| Strain-specific defects in testicular development and sperm epigenetic patterns in 5,10-methylenetetrahydrofolate reductase-deficient mice. Chan D., Cushnie D.W., Neaga O.R., Lawrance A.K., Rozen R., Trasler J.M.
Endocrinology 151:3363-3373(2010) · Mapped (13) |
| Methylenetetrahydrofolate reductase (MTHFR) deficiency enhances resistance against cytomegalovirus infection. Fodil-Cornu N., Kozij N., Wu Q., Rozen R., Vidal S.M.
Genes Immun. 10:662-666(2009) · Mapped (11) |
| Hyperhomocysteinemia is associated with hypertriglyceridemia in mice with methylenetetrahydrofolate reductase deficiency. Mikael L.G., Wang X.L., Wu Q., Jiang H., Maclean K.N., Rozen R.
Mol. Genet. Metab. 98:187-194(2009) · Mapped (27) |
| Vasculopathic and thrombophilic risk factors for spontaneous preterm birth. Kramer M.S., Kahn S.R., Rozen R., Evans R., Platt R.W., Chen M.F., Goulet L., Seguin L., Dassa C., Lydon J. et al.
Int J Epidemiol 38:715-723(2009) · Mapped (33) |
| Methylenetetrahydrofolate reductase deficiency and low dietary folate increase embryonic delay and placental abnormalities in mice. Pickell L., Li D., Brown K., Mikael L.G., Wang X.L., Wu Q., Luo L., Jerome-Majewska L., Rozen R.
Birth Defects Res. Part A Clin. Mol. Teratol. 85:531-541(2009) · Mapped (11) |
| Intestinal neoplasia induced by low dietary folate is associated with altered tumor expression profiles and decreased apoptosis in mouse normal intestine. Garcia-Crespo D., Knock E., Jabado N., Rozen R.
J. Nutr. 139:488-494(2009) · Mapped (13) |
| Inherited thrombophilia and preeclampsia within a multicenter cohort: the Montreal Preeclampsia Study. Kahn S.R., Platt R., McNamara H., Rozen R., Chen M.F., Genest J. Jr., Goulet L., Lydon J., Seguin L., Dassa C. et al.
Am. J. Obstet. Gynecol. 200:151.e1-9(2009) · Mapped (21) |
| The MTHFD1 p.Arg653Gln variant alters enzyme function and increases risk for congenital heart defects. Christensen K.E., Rohlicek C.V., Andelfinger G.U., Michaud J., Bigras J.-L., Richter A., Mackenzie R.E., Rozen R.
Hum. Mutat. 30:212-220(2009) · UniProtKB (1) · Mapped (2) |
| Reduced folate carrier 80A-->G polymorphism, plasma folate, and risk of placental abruption. Ananth C.V., Peltier M.R., Moore D.F., Kinzler W.L., Leclerc D., Rozen R.R.
Hum. Genet. 124:137-145(2008) · Mapped (2) |
| Valproic acid increases expression of methylenetetrahydrofolate reductase (MTHFR) and induces lower teratogenicity in MTHFR deficiency. Roy M., Leclerc D., Wu Q., Gupta S., Kruger W.D., Rozen R.
J. Cell. Biochem. 105:467-476(2008) · Mapped (17) |
| Altered expression of methylenetetrahydrofolate reductase modifies response to methotrexate in mice. Celtikci B., Leclerc D., Lawrance A.K., Deng L., Friedman H.C., Krupenko N.I., Krupenko S.A., Melnyk S., James S.J., Peterson A.C. et al.
Pharmacogenet. Genomics 18:577-589(2008) · Mapped (11) |
| Homocysteine modulates the effect of simvastatin on expression of ApoA-I and NF-kappaB/iNOS. Mikael L.G., Rozen R.
Cardiovasc. Res. 80:151-158(2008) · Mapped (5) |
| Methionine synthase reductase deficiency results in adverse reproductive outcomes and congenital heart defects in mice. Deng L., Elmore C.L., Lawrance A.K., Matthews R.G., Rozen R.
Mol. Genet. Metab. 94:336-342(2008) · Mapped (1) |
| Strain differences in mice highlight the role of DNA damage in neoplasia induced by low dietary folate. Knock E., Deng L., Wu Q., Lawrance A.K., Wang X.L., Rozen R.
J. Nutr. 138:653-658(2008) · Mapped (13) |
| Endoplasmic reticulum stress increases the expression of methylenetetrahydrofolate reductase through the IRE1 transducer. Leclerc D., Rozen R.
J. Biol. Chem. 283:3151-3160(2008) · Mapped (28) |
| Associations between 2 polymorphisms in the methylenetetrahydrofolate reductase gene and placental abruption. Ananth C.V., Peltier M.R., De Marco C., Elsasser D.A., Getahun D., Rozen R., Smulian J.C.
Am. J. Obstet. Gynecol. 197:385.e1-7(2007) · Mapped (6) |
| Betaine supplementation improves the atherogenic risk factor profile in a transgenic mouse model of hyperhomocysteinemia. Schwahn B.C., Wang X.L., Mikael L.G., Wu Q., Cohn J., Jiang H., Maclean K.N., Rozen R.
Atherosclerosis 195:e100-7(2007) · Mapped (11) |
| Polymorphisms in methionine synthase reductase and betaine-homocysteine S-methyltransferase genes: risk of placental abruption. Ananth C.V., Elsasser D.A., Kinzler W.L., Peltier M.R., Getahun D., Leclerc D., Rozen R.R.
Mol. Genet. Metab. 91:104-110(2007) · Mapped (6) |
| Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase. Elmore C.L., Wu X., Leclerc D., Watson E.D., Bottiglieri T., Krupenko N.I., Krupenko S.A., Cross J.C., Rozen R., Gravel R.A. et al.
Mol. Genet. Metab. 91:85-97(2007) · Mapped (1) |
