| Role of calcium-independent phospholipase A(2)beta in human pancreatic islet beta-cell apoptosis. Lei X., Zhang S., Bohrer A., Barbour S.E., Ramanadham S.
Am. J. Physiol. Endocrinol. Metab. 303:E1386-95(2012) · Mapped (10) |
| Evidence for proteolytic processing and stimulated organelle redistribution of iPLA(2)beta. Song H., Bao S., Lei X., Jin C., Zhang S., Turk J., Ramanadham S.
Biochim. Biophys. Acta 1801:547-558(2010) · Mapped (1) |
| HIV-protease inhibitors suppress skeletal muscle fatty acid oxidation by reducing CD36 and CPT1 fatty acid transporters. Richmond S.R., Carper M.J., Lei X., Zhang S., Yarasheski K.E., Ramanadham S.
Biochim. Biophys. Acta 1801:559-566(2010) · Mapped (11) |
| Spontaneous development of endoplasmic reticulum stress that can lead to diabetes mellitus is associated with higher calcium-independent phospholipase A2 expression: a role for regulation by SREBP-1. Lei X., Zhang S., Barbour S.E., Bohrer A., Ford E.L., Koizumi A., Papa F.R., Ramanadham S.
J. Biol. Chem. 285:6693-6705(2010) · Mapped (4) |
| Skeletal muscle group VIA phospholipase A2 (iPLA2beta): expression and role in fatty acid oxidation. Carper M.J., Zhang S., Turk J., Ramanadham S.
Biochemistry 47:12241-12249(2008) · Mapped (8) |
| Calcium-independent phospholipase A2 (iPLA2 beta)-mediated ceramide generation plays a key role in the cross-talk between the endoplasmic reticulum (ER) and mitochondria during ER stress-induced insulin-secreting cell apoptosis. Lei X., Zhang S., Bohrer A., Ramanadham S.
J. Biol. Chem. 283:34819-34832(2008) · Mapped (1) |
| Age-related changes in bone morphology are accelerated in group VIA phospholipase A2 (iPLA2beta)-null mice. Ramanadham S., Yarasheski K.E., Silva M.J., Wohltmann M., Novack D.V., Christiansen B., Tu X., Zhang S., Lei X., Turk J.
Am. J. Pathol. 172:868-881(2008) · Mapped (7) |
| HIV-protease inhibitors induce expression of suppressor of cytokine signaling-1 in insulin-sensitive tissues and promote insulin resistance and type 2 diabetes mellitus. Carper M.J., Cade W.T., Cam M., Zhang S., Shalev A., Yarasheski K.E., Ramanadham S.
Am. J. Physiol. Endocrinol. Metab. 294:E558-67(2008) · Mapped (4) |
| The group VIA calcium-independent phospholipase A2 participates in ER stress-induced INS-1 insulinoma cell apoptosis by promoting ceramide generation via hydrolysis of sphingomyelins by neutral sphingomyelinase. Lei X., Zhang S., Bohrer A., Bao S., Song H., Ramanadham S.
Biochemistry 46:10170-10185(2007) · Mapped (1) |
| Attenuated free cholesterol loading-induced apoptosis but preserved phospholipid composition of peritoneal macrophages from mice that do not express group VIA phospholipase A2. Bao S., Li Y., Lei X., Wohltmann M., Jin W., Bohrer A., Semenkovich C.F., Ramanadham S., Tabas I., Turk J.
J. Biol. Chem. 282:27100-27114(2007) · Mapped (7) |
| Insulin secretory responses and phospholipid composition of pancreatic islets from mice that do not express Group VIA phospholipase A2 and effects of metabolic stress on glucose homeostasis. Bao S., Song H., Wohltmann M., Ramanadham S., Jin W., Bohrer A., Turk J.
J. Biol. Chem. 281:20958-20973(2006) · Mapped (7) |
| Group VIA phospholipase A2 forms a signaling complex with the calcium/calmodulin-dependent protein kinase IIbeta expressed in pancreatic islet beta-cells. Wang Z., Ramanadham S., Ma Z.A., Bao S., Mancuso D.J., Gross R.W., Turk J.
J. Biol. Chem. 280:6840-6849(2005) · Mapped (7) |
| The expression and function of a group VIA calcium-independent phospholipase A2 (iPLA2beta) in beta-cells. Turk J., Ramanadham S.
Can. J. Physiol. Pharmacol. 82:824-832(2004) · Mapped (10) |
| Male mice that do not express group VIA phospholipase A2 produce spermatozoa with impaired motility and have greatly reduced fertility. Bao S., Miller D.J., Ma Z., Wohltmann M., Eng G., Ramanadham S., Moley K., Turk J.
J. Biol. Chem. 279:38194-38200(2004) · Mapped (7) |
| Beta-cell calcium-independent group VIA phospholipase A(2) (iPLA(2)beta): tracking iPLA(2)beta movements in response to stimulation with insulin secretagogues in INS-1 cells. Bao S., Jin C., Zhang S., Turk J., Ma Z., Ramanadham S.
Diabetes 53 Suppl 1:S186-9(2004) · Mapped (10) |
| Studies of insulin secretory responses and of arachidonic acid incorporation into phospholipids of stably transfected insulinoma cells that overexpress group VIA phospholipase A2 (iPLA2beta ) indicate a signaling rather than a housekeeping role for iPLA2beta. Ma Z., Ramanadham S., Wohltmann M., Bohrer A., Hsu F.F., Turk J.
J. Biol. Chem. 276:13198-13208(2001) · Mapped (1) |
| Human pancreatic islets express mRNA species encoding two distinct catalytically active isoforms of group VI phospholipase A2 (iPLA2) that arise from an exon-skipping mechanism of alternative splicing of the transcript from the iPLA2 gene on chromosome 22q13.1. Ma Z., Wang X., Nowatzke W., Ramanadham S., Turk J.
J. Biol. Chem. 274:9607-9616(1999) · UniProtKB (1) |
| Cloning and expression of a group IV cytosolic Ca2+-dependent phospholipase A2 from rat pancreatic islets. Comparison of the expressed activity with that of an islet group VI cytosolic Ca2+-independent phospholipase A2. Ma Z., Ramanadham S., Hu Z., Turk J.
Biochim. Biophys. Acta 1391:384-400(1998) · UniProtKB (1) · Mapped (2) |
| Type IB secretory phospholipase A2 is contained in insulin secretory granules of pancreatic islet beta-cells and is co-secreted with insulin from glucose-stimulated islets. Ramanadham S., Ma Z., Arita H., Zhang S., Turk J.
Biochim. Biophys. Acta 1390:301-312(1998) · Mapped (3) |
| Pancreatic islets express a Ca2+-independent phospholipase A2 enzyme that contains a repeated structural homologous to the integral membrane protein binding domain of ankyrin. Ma Z., Ramanadham S., Kempe K., Chi X.S., Ladenson J., Turk J.
J. Biol. Chem. 272:11118-11127(1997) · UniProtKB (1) |
| Characterization of expression of phosphofructokinase isoforms in isolated rat pancreatic islets and purified beta cells and cloning and expression of the rat phosphofructokinase-A isoform. Ma Z., Ramanadham S., Turk J., Kempe K., Hu Z., Ladenson J.
Biochim. Biophys. Acta 1308:151-163(1996) · UniProtKB (1) · Mapped (2) |
| Pancreatic islet cells express a family of inwardly rectifying K+ channel subunits which interact to form G-protein-activated channels. Ferrer J., Nichols C.G., Makhina E.N., Salkoff L., Bernstein J., Gerhard D., Wasson J., Ramanadham S., Permutt A.
J. Biol. Chem. 270:26086-26091(1995) · UniProtKB (2) |
