| Impaired associative taste learning and abnormal brain activation in kinase-defective eEF2K mice. Gildish I., Manor D., David O., Sharma V., Williams D., Agarwala U., Wang X., Kenney J.W., Proud C.G., Rosenblum K.
Learn. Mem. 19:116-125(2012) · Mapped (6) |
| Identification of autophosphorylation sites in eukaryotic elongation factor-2 kinase. Pyr Dit Ruys S., Wang X., Smith E.M., Herinckx G., Hussain N., Rider M.H., Vertommen D., Proud C.G.
Biochem. J. 442:681-692(2012) · UniProtKB (1) |
| Insights into the regulation of eukaryotic elongation factor 2 kinase and the interplay between its domains. Pigott C.R., Mikolajek H., Moore C.E., Finn S.J., Phippen C.W., Werner J.M., Proud C.G.
Biochem. J. 442:105-118(2012) · Mapped (1) |
| Adult-onset leukoencephalopathies with vanishing white matter with novel missense mutations in EIF2B2, EIF2B3, and EIF2B5. Matsukawa T., Wang X., Liu R., Wortham N.C., Onuki Y., Kubota A., Hida A., Kowa H., Fukuda Y., Ishiura H. et al.
Neurogenetics 12:259-261(2011) · UniProtKB (3) |
| mTOR Signalling in Health and Disease. Proud C.G.
Biochem. Soc. Trans. 39:431-436(2011) · Mapped (5) |
| Functional analysis of recently identified mutations in eukaryotic translation initiation factor 2Bɛ (eIF2Bɛ) identified in Chinese patients with vanishing white matter disease. Leng X., Wu Y., Wang X., Pan Y., Wang J., Li J., Du L., Dai L., Wu X., Proud C.G. et al.
J. Hum. Genet. 56:300-305(2011) · Mapped (2) |
| Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling. Balgi A.D., Fonseca B.D., Donohue E., Tsang T.C., Lajoie P., Proud C.G., Nabi I.R., Roberge M.
PLoS ONE 4:e7124-e7124(2009) · Mapped (5) |
| ABC50 promotes translation initiation in mammalian cells. Paytubi S., Wang X., Lam Y.W., Izquierdo L., Hunter M.J., Jan E., Hundal H.S., Proud C.G.
J. Biol. Chem. 284:24061-24073(2009) · UniProtKB (1) · Mapped (4) |
| Re-evaluating the roles of proposed modulators of mammalian target of rapamycin complex 1 (mTORC1) signaling. Wang X., Fonseca B.D., Tang H., Liu R., Elia A., Clemens M.J., Bommer U.A., Proud C.G.
J. Biol. Chem. 283:30482-30492(2008) · Mapped (4) |
| Protein kinase D is a key regulator of cardiomyocyte lipoprotein lipase secretion after diabetes. Kim M.S., Wang F., Puthanveetil P., Kewalramani G., Hosseini-Beheshti E., Ng N., Wang Y., Kumar U., Innis S., Proud C.G. et al.
Circ. Res. 103:252-260(2008) · Mapped (1) |
| The Mnks: MAP kinase-interacting kinases (MAP kinase signal-integrating kinases). Buxade M., Parra-Palau J.L., Proud C.G.
Front. Biosci. 13:5359-5373(2008) · UniProtKB (1) |
| Analysis of the regulatory motifs in eukaryotic initiation factor 4E-binding protein 1. Lee V.H., Healy T., Fonseca B.D., Hayashi A., Proud C.G.
FEBS J. 275:2185-2199(2008) · Mapped (1) |
| cdc2-cyclin B regulates eEF2 kinase activity in a cell cycle- and amino acid-dependent manner. Smith E.M., Proud C.G.
EMBO J. 27:1005-1016(2008) · UniProtKB (1) · Mapped (18) |
| The binding of PRAS40 to 14-3-3 proteins is not required for activation of mTORC1 signalling by phorbol esters/ERK. Fonseca B.D., Lee V.H., Proud C.G.
Biochem. J. 411:141-149(2008) · Mapped (12) |
| A novel mechanism for the control of translation initiation by amino acids, mediated by phosphorylation of eukaryotic initiation factor 2B. Wang X., Proud C.G.
Mol. Cell. Biol. 28:1429-1442(2008) · Mapped (7) |
| The PSF.p54nrb complex is a novel Mnk substrate that binds the mRNA for tumor necrosis factor alpha. Buxade M., Morrice N., Krebs D.L., Proud C.G.
J. Biol. Chem. 283:57-65(2008) · UniProtKB (2) · Mapped (6) |
| The N-terminal region of ABC50 interacts with eukaryotic initiation factor eIF2 and is a target for regulatory phosphorylation by CK2. Paytubi S., Morrice N.A., Boudeau J., Proud C.G.
Biochem. J. 409:223-231(2008) · UniProtKB (2) · Mapped (12) |
| Regulation of cyclin D1 expression by mTORC1 signaling requires eukaryotic initiation factor 4E-binding protein 1. Averous J., Fonseca B.D., Proud C.G.
Oncogene 27:1106-1113(2008) · Mapped (1) |
| PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex. Fonseca B.D., Smith E.M., Lee V.H., MacKintosh C., Proud C.G.
J. Biol. Chem. 282:24514-24524(2007) · Mapped (16) |
| Structure of the eukaryotic initiation factor (eIF) 5 reveals a fold common to several translation factors. Conte M.R., Kelly G., Babon J., Sanfelice D., Youell J., Smerdon S.J., Proud C.G.
Biochemistry 45:4550-4558(2006) · Mapped (5) |
| Exercise rapidly increases eukaryotic elongation factor 2 phosphorylation in skeletal muscle of men. Rose A.J., Broholm C., Kiillerich K., Finn S.G., Proud C.G., Rider M.H., Richter E.A., Kiens B.
J. Physiol. (Lond.) 569:223-228(2005) · Mapped (3) |
| Features of the catalytic domains and C termini of the MAPK signal-integrating kinases Mnk1 and Mnk2 determine their differing activities and regulatory properties. Parra J.L., Buxade M., Proud C.G.
J. Biol. Chem. 280:37623-37633(2005) · UniProtKB (3) · Mapped (11) |
| The Mnks are novel components in the control of TNF alpha biosynthesis and phosphorylate and regulate hnRNP A1. Buxade M., Parra J.L., Rousseau S., Shpiro N., Marquez R., Morrice N., Bain J., Espel E., Proud C.G.
Immunity 23:177-189(2005) · UniProtKB (2) |
| Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1. Tee A.R., Blenis J., Proud C.G.
FEBS Lett. 579:4763-4768(2005) · UniProtKB (2) · Mapped (3) |
| The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses. Smith E.M., Finn S.G., Tee A.R., Browne G.J., Proud C.G.
J. Biol. Chem. 280:18717-18727(2005) · Mapped (15) |
