1 - 25 of 56 results for author:"Prodromou C." in Literature citations
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| Co-crystalization and in vitro biological characterization of 5-aryl-4-(5-substituted-2-4-dihydroxyphenyl)-1,2,3-thiadiazole Hsp90 inhibitors. Sharp S.Y., Roe S.M., Kazlauskas E., Cikotiene I., Workman P., Matulis D., Prodromou C. PLoS ONE 7:e44642-e44642(2012) · Mapped (1) |
| Dynamic tyrosine phosphorylation modulates cycling of the HSP90-P50(CDC37)-AHA1 chaperone machine. Xu W., Mollapour M., Prodromou C., Wang S., Scroggins B.T., Palchick Z., Beebe K., Siderius M., Lee M.J., Couvillon A. et al. Mol. Cell 47:434-443(2012) · Mapped (5) |
| Charged linker sequence modulates eukaryotic heat shock protein 90 (Hsp90) chaperone activity. Tsutsumi S., Mollapour M., Prodromou C., Lee C.T., Panaretou B., Yoshida S., Mayer M.P., Neckers L.M. Proc. Natl. Acad. Sci. U.S.A. 109:2937-2942(2012) · Mapped (8) |
| Targeting the Hsp90 molecular chaperone with novel macrolactams. Synthesis, structural, binding, and cellular studies. Day J.E., Sharp S.Y., Rowlands M.G., Aherne W., Hayes A., Raynaud F.I., Lewis W., Roe S.M., Prodromou C., Pearl L.H. et al. ACS Chem. Biol. 6:1339-1347(2011) · Mapped (1) |
| Features of the Streptomyces hygroscopicus HtpG reveal how partial geldanamycin resistance can arise with mutation to the ATP binding pocket of a eukaryotic Hsp90. Millson S.H., Chua C.S., Roe S.M., Polier S., Solovieva S., Pearl L.H., Sim T.S., Prodromou C., Piper P.W. |
| Threonine 22 phosphorylation attenuates Hsp90 interaction with cochaperones and affects its chaperone activity. Mollapour M., Tsutsumi S., Truman A.W., Xu W., Vaughan C.K., Beebe K., Konstantinova A., Vourganti S., Panaretou B., Piper P.W. et al. Mol. Cell 41:672-681(2011) · Mapped (8) |
| Structural basis for assembly of Hsp90-Sgt1-CHORD protein complexes: implications for chaperoning of NLR innate immunity receptors. Zhang M., Kadota Y., Prodromou C., Shirasu K., Pearl L.H. Mol. Cell 39:269-281(2010) · UniProtKB (3) |
| Inhibition of Hsp90 with resorcylic acid macrolactones: synthesis and binding studies. Day J.E., Sharp S.Y., Rowlands M.G., Aherne W., Lewis W., Roe S.M., Prodromou C., Pearl L.H., Workman P., Moody C.J. Chemistry 16:10366-10372(2010) · Mapped (2) |
| Swe1Wee1-dependent tyrosine phosphorylation of Hsp90 regulates distinct facets of chaperone function. Mollapour M., Tsutsumi S., Donnelly A.C., Beebe K., Tokita M.J., Lee M.J., Lee S., Morra G., Bourboulia D., Scroggins B.T. et al. Mol. Cell 37:333-343(2010) · Mapped (9) |
| Detection of the ATPase activity of the molecular chaperones Hsp90 and Hsp72 using the TranscreenerTM ADP assay kit. Rowlands M., McAndrew C., Prodromou C., Pearl L., Kalusa A., Jones K., Workman P., Aherne W. J Biomol Screen 15:279-286(2010) · Mapped (3) |
| A simple yeast-based system for analyzing inhibitor resistance in the human cancer drug targets Hsp90alpha/beta. Millson S.H., Prodromou C., Piper P.W. Biochem. Pharmacol. 79:1581-1588(2010) · Mapped (11) |
| Hsp90 charged-linker truncation reverses the functional consequences of weakened hydrophobic contacts in the N domain. Tsutsumi S., Mollapour M., Graf C., Lee C.T., Scroggins B.T., Xu W., Haslerova L., Hessling M., Konstantinova A.A., Trepel J.B. et al. Nat. Struct. Mol. Biol. 16:1141-1147(2009) · Mapped (2) |
| Structural-thermodynamic relationships of interactions in the N-terminal ATP-binding domain of Hsp90. Nilapwar S., Williams E., Fu C., Prodromou C., Pearl L.H., Williams M.A., Ladbury J.E. J. Mol. Biol. 392:923-936(2009) · Mapped (2) |
| Structural basis of the radicicol resistance displayed by a fungal hsp90. Prodromou C., Nuttall J.M., Millson S.H., Roe S.M., Sim T.S., Tan D., Workman P., Pearl L.H., Piper P.W. ACS Chem. Biol. 4:289-297(2009) · UniProtKB (2) |
| A common conformationally coupled ATPase mechanism for yeast and human cytoplasmic HSP90s. Vaughan C.K., Piper P.W., Pearl L.H., Prodromou C. FEBS J. 276:199-209(2009) · Mapped (2) |
| Hsp90-dependent activation of protein kinases is regulated by chaperone-targeted dephosphorylation of Cdc37. Vaughan C.K., Mollapour M., Smith J.R., Truman A., Hu B., Good V.M., Panaretou B., Neckers L., Clarke P.A., Workman P. et al. Mol. Cell 31:886-895(2008) · Mapped (15) |
| Structural and functional coupling of Hsp90- and Sgt1-centred multi-protein complexes. Zhang M., Boter M., Li K., Kadota Y., Panaretou B., Prodromou C., Shirasu K., Pearl L.H. |
| Optimizing natural products by biosynthetic engineering: discovery of nonquinone Hsp90 inhibitors. Zhang M.Q., Gaisser S., Nur-E-Alam M., Sheehan L.S., Vousden W.A., Gaitatzis N., Peck G., Coates N.J., Moss S.J., Radzom M. et al. J. Med. Chem. 51:5494-5497(2008) · Mapped (1) |
| Chaperone ligand-discrimination by the TPR-domain protein Tah1. Millson S.H., Vaughan C.K., Zhai C., Ali M.M., Panaretou B., Piper P.W., Pearl L.H., Prodromou C. Biochem. J. 413:261-268(2008) · Mapped (13) |
| Molecular characterization of macbecin as an Hsp90 inhibitor. Martin C.J., Gaisser S., Challis I.R., Carletti I., Wilkinson B., Gregory M., Prodromou C., Roe S.M., Pearl L.H., Boyd S.M. et al. J. Med. Chem. 51:2853-2857(2008) · UniProtKB (1) |
| The ATPase-dependent chaperoning activity of Hsp90a regulates thick filament formation and integration during skeletal muscle myofibrillogenesis. Hawkins T.A., Haramis A.P., Etard C., Prodromou C., Vaughan C.K., Ashworth R., Ray S., Behra M., Holder N., Talbot W.S. et al. Development 135:1147-1156(2008) · UniProtKB (3) · Mapped (2) |
| 4,5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer. Brough P.A., Aherne W., Barril X., Borgognoni J., Boxall K., Cansfield J.E., Cheung K.M., Collins I., Davies N.G., Drysdale M.J. et al. J. Med. Chem. 51:196-218(2008) · Mapped (1) |
| DNA fragmentation based combinatorial approaches to soluble protein expression Part II: library expression, screening and scale-up. Savva R., Prodromou C., Driscoll P.C. Drug Discov. Today 12:939-947(2007) · Mapped (1) |
| Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues. Sharp S.Y., Prodromou C., Boxall K., Powers M.V., Holmes J.L., Box G., Matthews T.P., Cheung K.M., Kalusa A., James K. et al. Mol. Cancer Ther. 6:1198-1211(2007) · Mapped (1) |
| In the yeast heat shock response, Hsf1-directed induction of Hsp90 facilitates the activation of the Slt2 (Mpk1) mitogen-activated protein kinase required for cell integrity. Truman A.W., Millson S.H., Nuttall J.M., Mollapour M., Prodromou C., Piper P.W. Eukaryotic Cell 6:744-752(2007) · Mapped (9) |