| A single gene encodes isopentenyl diphosphate isomerase isoforms targeted to plastids, mitochondria and peroxisomes in Catharanthus roseus. Guirimand G., Guihur A., Phillips M.A., Oudin A., Glevarec G., Melin C., Papon N., Clastre M., St-Pierre B., Rodriguez-Concepcion M. et al.
Plant Mol. Biol. 79:443-459(2012) · UniProtKB (1) |
| Alternative spermidine biosynthetic route is critical for growth of Campylobacter jejuni and is the dominant polyamine pathway in human gut microbiota. Hanfrey C.C., Pearson B.M., Hazeldine S., Lee J., Gaskin D.J., Woster P.M., Phillips M.A., Michael A.J.
J. Biol. Chem. 286:43301-43312(2011) · UniProtKB (1) |
| Structure-guided lead optimization of triazolopyrimidine-ring substituents identifies potent Plasmodium falciparum dihydroorotate dehydrogenase inhibitors with clinical candidate potential. Coteron J.M., Marco M., Esquivias J., Deng X., White K.L., White J., Koltun M., El Mazouni F., Kokkonda S., Katneni K. et al.
J. Med. Chem. 54:5540-5561(2011) · Mapped (1) |
| Localization of hair shaft protein VSIG8 in the hair follicle, nail unit, and oral cavity. Rice R.H., Phillips M.A., Sundberg J.P.
J. Invest. Dermatol. 131:1936-1938(2011) · Mapped (1) |
| Novel inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with anti-malarial activity in the mouse model. Booker M.L., Bastos C.M., Kramer M.L., Barker R.H. Jr., Skerlj R., Sidhu A.B., Deng X., Celatka C., Cortese J.F., Guerrero Bravo J.E. et al.
J. Biol. Chem. 285:33054-33064(2010) · UniProtKB (1) |
| Evolution of substrate specificity within a diverse family of beta/alpha-barrel-fold basic amino acid decarboxylases: X-ray structure determination of enzymes with specificity for L-arginine and carboxynorspermidine. Deng X., Lee J., Michael A.J., Tomchick D.R., Goldsmith E.J., Phillips M.A.
J. Biol. Chem. 285:25708-25719(2010) · UniProtKB (2) · Mapped (1) |
| PLEIOTROPIC REGULATORY LOCUS 1 (PRL1) integrates the regulation of sugar responses with isoprenoid metabolism in Arabidopsis. Flores-Perez U., Perez-Gil J., Closa M., Wright L.P., Botella-Pavia P., Phillips M.A., Ferrer A., Gershenzon J., Rodriguez-Concepcion M.
Mol. Plant 3:101-112(2010) · UniProtKB (1) · Mapped (1) |
| Structural plasticity of malaria dihydroorotate dehydrogenase allows selective binding of diverse chemical scaffolds. Deng X., Gujjar R., El Mazouni F., Kaminsky W., Malmquist N.A., Goldsmith E.J., Rathod P.K., Phillips M.A.
J. Biol. Chem. 284:26999-27009(2009) · UniProtKB (1) |
| An alternative polyamine biosynthetic pathway is widespread in bacteria and essential for biofilm formation in Vibrio cholerae. Lee J., Sperandio V., Frantz D.E., Longgood J., Camilli A., Phillips M.A., Michael A.J.
J. Biol. Chem. 284:9899-9907(2009) · UniProtKB (2) |
| The plastidial MEP pathway: unified nomenclature and resources. Phillips M.A., Leon P., Boronat A., Rodriguez-Concepcion M.
Trends Plant Sci. 13:619-623(2008) · UniProtKB (1) · Mapped (7) |
| Arsenite suppresses Notch1 signaling in human keratinocytes. Reznikova T.V., Phillips M.A., Rice R.H.
J. Invest. Dermatol. 129:155-161(2009) · Mapped (3) |
| The Arabidopsis thaliana type I Isopentenyl Diphosphate Isomerases are targeted to multiple subcellular compartments and have overlapping functions in isoprenoid biosynthesis. Phillips M.A., D'Auria J.C., Gershenzon J., Pichersky E.
Plant Cell 20:677-696(2008) · Mapped (2) |
| Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies. Arakaki T.L., Buckner F.S., Gillespie J.R., Malmquist N.A., Phillips M.A., Kalyuzhniy O., Luft J.R., DeTitta G.T., Verlinde C.L.M.J., Van Voorhis W.C. et al.
Mol. Microbiol. 68:37-50(2008) · UniProtKB (1) |
| cpg15 and cpg15-2 constitute a family of activity-regulated ligands expressed differentially in the nervous system to promote neurite growth and neuronal survival. Fujino T., Wu Z., Lin W.C., Phillips M.A., Nedivi E.
J. Comp. Neurol. 507:1831-1845(2008) · UniProtKB (1) · Mapped (6) |
| Functional identification and differential expression of 1-deoxy-D-xylulose 5-phosphate synthase in induced terpenoid resin formation of Norway spruce (Picea abies). Phillips M.A., Walter M.H., Ralph S.G., Dabrowska P., Luck K., Uros E.M., Boland W., Strack D., Rodriguez-Concepcion M., Bohlmann J. et al.
Plant Mol. Biol. 65:243-257(2007) · UniProtKB (3) |
| Phylogenetic diversity and the structural basis of substrate specificity in the beta/alpha-barrel fold basic amino acid decarboxylases. Lee J., Michael A.J., Martynowski D., Goldsmith E.J., Phillips M.A.
J. Biol. Chem. 282:27115-27125(2007) · UniProtKB (1) |
| X-ray structure of Paramecium bursaria Chlorella virus arginine decarboxylase: insight into the structural basis for substrate specificity. Shah R., Akella R., Goldsmith E.J., Phillips M.A.
Biochemistry 46:2831-2841(2007) · UniProtKB (1) |
| Multiple active site conformations revealed by distant site mutation in ornithine decarboxylase. Jackson L.K., Baldwin J., Akella R., Goldsmith E.J., Phillips M.A.
Biochemistry 43:12990-12999(2004) · Mapped (1) |
| The thrH gene product of Pseudomonas aeruginosa is a dual activity enzyme with a novel phosphoserine:homoserine phosphotransferase activity. Singh S.K., Yang K., Karthikeyan S., Huynh T., Zhang X., Phillips M.A., Zhang H.
J. Biol. Chem. 279:13166-13173(2004) · UniProtKB (1) |
| Distinct light-mediated pathways regulate the biosynthesis and exchange of isoprenoid precursors during Arabidopsis seedling development. Rodriguez-Concepcion M., Fores O., Martinez-Garcia J.F., Gonzalez V., Phillips M.A., Ferrer A., Boronat A.
Plant Cell 16:144-156(2004) · Mapped (1) |
| X-ray structure determination of Trypanosoma brucei ornithine decarboxylase bound to D-ornithine and to G418: insights into substrate binding and ODC conformational flexibility. Jackson L.K., Goldsmith E.J., Phillips M.A.
J. Biol. Chem. 278:22037-22043(2003) · UniProtKB (1) |
| cDNA isolation, functional expression, and characterization of (+)-alpha-pinene synthase and (-)-alpha-pinene synthase from loblolly pine (Pinus taeda): stereocontrol in pinene biosynthesis. Phillips M.A., Wildung M.R., Williams D.C., Hyatt D.C., Croteau R.
Arch. Biochem. Biophys. 411:267-276(2003) · UniProtKB (5) |
| Altering the reaction specificity of eukaryotic ornithine decarboxylase. Jackson L.K., Brooks H.B., Osterman A.L., Goldsmith E.J., Phillips M.A.
Biochemistry 39:11247-11257(2000) · UniProtKB (1) |
| Crystal structure of human ornithine decarboxylase at 2.1 A resolution: structural insights to antizyme binding. Almrud J.J., Oliveira M.A., Kern A.D., Grishin N.V., Phillips M.A., Hackert M.L.
J. Mol. Biol. 295:7-16(2000) · UniProtKB (1) · Mapped (3) |
| X-ray structure of ornithine decarboxylase from Trypanosoma brucei: the native structure and the structure in complex with alpha-difluoromethylornithine. Grishin N.V., Osterman A.L., Brooks H.B., Phillips M.A., Goldsmith E.J.
Biochemistry 38:15174-15184(1999) · UniProtKB (1) |
