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Impact of ACE2 deficiency and oxidative stress on cerebrovascular function with aging.

Pena Silva R.A., Chu Y., Miller J.D., Mitchell I.J., Penninger J.M., Faraci F.M., Heistad D.D.

Stroke 43:3358-3363(2012) · Mapped (5)

Developmentally regulated availability of RANKL and CD40 ligand reveals distinct mechanisms of fetal and adult cross-talk in the thymus medulla.

Desanti G.E., Cowan J.E., Baik S., Parnell S.M., White A.J., Penninger J.M., Lane P.J., Jenkinson E.J., Jenkinson W.E., Anderson G.

J. Immunol. 189:5519-5526(2012) · Mapped (5)

Hedgehog partial agonism drives Warburg-like metabolism in muscle and brown fat.

Teperino R., Amann S., Bayer M., McGee S.L., Loipetzberger A., Connor T., Jaeger C., Kammerer B., Winter L., Wiche G. et al.

Cell 151:414-426(2012) · Mapped (4)

Converging evidence that sequence variations in the novel candidate gene MAP2K7 (MKK7) are functionally associated with schizophrenia.

Winchester C.L., Ohzeki H., Vouyiouklis D.A., Thompson R., Penninger J.M., Yamagami K., Norrie J.D., Hunter R., Pratt J.A., Morris B.J.

Hum. Mol. Genet. 21:4910-4921(2012) · Mapped (1)

ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation.

Hashimoto T., Perlot T., Rehman A., Trichereau J., Ishiguro H., Paolino M., Sigl V., Hanada T., Hanada R., Lipinski S. et al.

Nature 487:477-481(2012) · Mapped (13)

Defective intestinal amino acid absorption in Ace2 null mice.

Singer D., Camargo S.M., Ramadan T., Schafer M., Mariotta L., Herzog B., Huggel K., Wolfer D., Werner S., Penninger J.M. et al.

Am. J. Physiol. Gastrointest. Liver Physiol. 303:G686-95(2012) · Mapped (5)

Bnip3 and AIF cooperate to induce apoptosis and cavitation during epithelial morphogenesis.

Qi Y., Tian X., Liu J., Han Y., Graham A.M., Simon M.C., Penninger J.M., Carmeliet P., Li S.

J. Cell Biol. 198:103-114(2012) · Mapped (11)

ACE2 deficiency enhances angiotensin II-mediated aortic profilin-1 expression, inflammation and peroxynitrite production.

Jin H.Y., Song B., Oudit G.Y., Davidge S.T., Yu H.M., Jiang Y.Y., Gao P.J., Zhu D.L., Ning G., Kassiri Z. et al.

PLoS ONE 7:e38502-e38502(2012) · Mapped (4)

Spleen serves as a reservoir of osteoclast precursors through vitamin D-induced IL-34 expression in osteopetrotic op/op mice.

Nakamichi Y., Mizoguchi T., Arai A., Kobayashi Y., Sato M., Penninger J.M., Yasuda H., Kato S., DeLuca H.F., Suda T. et al.

Proc. Natl. Acad. Sci. U.S.A. 109:10006-10011(2012) · Mapped (16)

Fos plays an essential role in the upregulation of RANK expression in osteoclast precursors within the bone microenvironment.

Arai A., Mizoguchi T., Harada S., Kobayashi Y., Nakamichi Y., Yasuda H., Penninger J.M., Yamada K., Udagawa N., Takahashi N.

J. Cell. Sci. 125:2910-2917(2012) · Mapped (1)

Rank signaling links the development of invariant gammadelta T cell progenitors and Aire(+) medullary epithelium.

Roberts N.A., White A.J., Jenkinson W.E., Turchinovich G., Nakamura K., Withers D.R., McConnell F.M., Desanti G.E., Benezech C., Parnell S.M. et al.

Immunity 36:427-437(2012) · Mapped (36)

Loss of angiotensin-converting enzyme 2 enhances TGF-beta/Smad-mediated renal fibrosis and NF-kappaB-driven renal inflammation in a mouse model of obstructive nephropathy.

Liu Z., Huang X.R., Chen H.Y., Penninger J.M., Lan H.Y.

Lab. Invest. 92:650-661(2012) · Mapped (8)

Development and function of murine B cells lacking RANK.

Perlot T., Penninger J.M.

J. Immunol. 188:1201-1205(2012) · Mapped (2)

Stress-activated protein kinase MKK7 regulates axon elongation in the developing cerebral cortex.

Yamasaki T., Kawasaki H., Arakawa S., Shimizu K., Shimizu S., Reiner O., Okano H., Nishina S., Azuma N., Penninger J.M. et al.

J. Neurosci. 31:16872-16883(2011) · Mapped (81)

A RANKL G278R mutation causing osteopetrosis identifies a functional amino acid essential for trimer assembly in RANKL and TNF.

Douni E., Rinotas V., Makrinou E., Zwerina J., Penninger J.M., Eliopoulos E., Schett G., Kollias G.

Hum. Mol. Genet. 21:784-798(2012) · Mapped (2)

Osteoclasts are dispensable for hematopoietic stem cell maintenance and mobilization.

Miyamoto K., Yoshida S., Kawasumi M., Hashimoto K., Kimura T., Sato Y., Kobayashi T., Miyauchi Y., Hoshi H., Iwasaki R. et al.

J. Exp. Med. 208:2175-2181(2011) · Mapped (12)

Gab2 promotes colony-stimulating factor 1-regulated macrophage expansion via alternate effectors at different stages of development.

Lee A.W., Mao Y., Penninger J.M., Yu S.

Mol. Cell. Biol. 31:4563-4581(2011) · Mapped (18)

TrpA1 regulates thermal nociception in Drosophila.

Neely G.G., Keene A.C., Duchek P., Chang E.C., Wang Q.P., Aksoy Y.A., Rosenzweig M., Costigan M., Woolf C.J., Garrity P.A. et al.

PLoS ONE 6:e24343-e24343(2011) · Mapped (1)

Evidence for osteocyte regulation of bone homeostasis through RANKL expression.

Nakashima T., Hayashi M., Fukunaga T., Kurata K., Oh-Hora M., Feng J.Q., Bonewald L.F., Kodama T., Wutz A., Wagner E.F. et al.

Nat. Med. 17:1231-1234(2011) · Mapped (2)

[Central regulation of body temperature by RANKL/RANK pathway].

Hanada R., Penninger J.M.

Clin Calcium 21:1201-1208(2011) · Mapped (6)

Variants in STAT5B associate with serum TC and LDL-C levels.

Kornfeld J.W., Isaacs A., Vitart V., Pospisilik J.A., Meitinger T., Gyllensten U., Wilson J.F., Rudan I., Campbell H., Penninger J.M. et al.

J. Clin. Endocrinol. Metab. 96:E1496-501(2011) · Mapped (3)

Phosphatidylinositol-3-kinase gamma plays a central role in blood-brain barrier dysfunction in acute experimental stroke.

Jin R., Song Z., Yu S., Piazza A., Nanda A., Penninger J.M., Granger D.N., Li G.

Stroke 42:2033-2044(2011) · Mapped (8)

Monoglyceride lipase deficiency in mice impairs lipolysis and attenuates diet-induced insulin resistance.

Taschler U., Radner F.P., Heier C., Schreiber R., Schweiger M., Schoiswohl G., Preiss-Landl K., Jaeger D., Reiter B., Koefeler H.C. et al.

J. Biol. Chem. 286:17467-17477(2011) · Mapped (7)

Lymphotoxin signal promotes thymic organogenesis by eliciting RANK expression in the embryonic thymic stroma.

Mouri Y., Yano M., Shinzawa M., Shimo Y., Hirota F., Nishikawa Y., Nii T., Kiyonari H., Abe T., Uehara H. et al.

J. Immunol. 186:5047-5057(2011) · Mapped (23)

Reinforcement of cancer immunotherapy by adoptive transfer of cblb-deficient CD8+ T cells combined with a DC vaccine.

Lutz-Nicoladoni C., Wallner S., Stoitzner P., Pircher M., Gruber T., Wolf A.M., Gastl G., Penninger J.M., Baier G., Wolf D.

Immunol. Cell Biol. 90:130-134(2012) · Mapped (3)

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