22 results for author:"Pandit J." in Literature citations
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| Discovery and optimization of a novel spiropyrrolidine inhibitor of beta-secretase (BACE1) through fragment-based drug design. Efremov I.V., Vajdos F.F., Borzilleri K.A., Capetta S., Chen H., Dorff P.H., Dutra J.K., Goldstein S.W., Mansour M., McColl A. et al. J. Med. Chem. 55:9069-9088(2012) · Mapped (1) |
| Use of structure-based design to discover a potent, selective, in vivo active phosphodiesterase 10A inhibitor lead series for the treatment of schizophrenia. Helal C.J., Kang Z., Hou X., Pandit J., Chappie T.A., Humphrey J.M., Marr E.S., Fennell K.F., Chenard L.K., Fox C. et al. J. Med. Chem. 54:4536-4547(2011) · Mapped (1) |
| 6-amino-4-(pyrimidin-4-yl)pyridones: novel glycogen synthase kinase-3beta inhibitors. Coffman K., Brodney M., Cook J., Lanyon L., Pandit J., Sakya S., Schachter J., Tseng-Lovering E., Wessel M. Bioorg. Med. Chem. Lett. 21:1429-1433(2011) · Mapped (1) |
| Design of selective, ATP-competitive inhibitors of Akt. Freeman-Cook K.D., Autry C., Borzillo G., Gordon D., Barbacci-Tobin E., Bernardo V., Briere D., Clark T., Corbett M., Jakubczak J. et al. J. Med. Chem. 53:4615-4622(2010) · UniProtKB (2) · Mapped (1) |
| Mechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length construct. Pandit J., Forman M.D., Fennell K.F., Dillman K.S., Menniti F.S. Proc. Natl. Acad. Sci. U.S.A. 106:18225-18230(2009) · UniProtKB (1) · Mapped (8) |
| Potent and cellularly active 4-aminoimidazole inhibitors of cyclin-dependent kinase 5/p25 for the treatment of Alzheimer's disease. Helal C.J., Kang Z., Lucas J.C., Gant T., Ahlijanian M.K., Schachter J.B., Richter K.E., Cook J.M., Menniti F.S., Kelly K. et al. Bioorg. Med. Chem. Lett. 19:5703-5707(2009) · Mapped (1) |
| Discovery of a novel class of phosphodiesterase 10A inhibitors and identification of clinical candidate 2-[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the treatment of schizophrenia. Verhoest P.R., Chapin D.S., Corman M., Fonseca K., Harms J.F., Hou X., Marr E.S., Menniti F.S., Nelson F., O'Connor R. et al. J. Med. Chem. 52:5188-5196(2009) · Mapped (1) |
| Synthesis and structure based optimization of novel Akt inhibitors. Lippa B., Pan G., Corbett M., Li C., Kauffman G.S., Pandit J., Robinson S., Wei L., Kozina E., Marr E.S. et al. Bioorg. Med. Chem. Lett. 18:3359-3363(2008) · UniProtKB (1) · Mapped (1) |
| The 2.0 A crystal structure of the ERalpha ligand-binding domain complexed with lasofoxifene. Vajdos F.F., Hoth L.R., Geoghegan K.F., Simons S.P., LeMotte P.K., Danley D.E., Ammirati M.J., Pandit J. Protein Sci. 16:897-905(2007) · Mapped (1) |
| Discovery of a series of 6,7-dimethoxy-4-pyrrolidylquinazoline PDE10A inhibitors. Chappie T.A., Humphrey J.M., Allen M.P., Estep K.G., Fox C.B., Lebel L.A., Liras S., Marr E.S., Menniti F.S., Pandit J. et al. J. Med. Chem. 50:182-185(2007) · UniProtKB (1) |
| Theoretical and experimental design of atypical kinase inhibitors: application to p38 MAP kinase. McClure K.F., Abramov Y.A., Laird E.R., Barberia J.T., Cai W., Carty T.J., Cortina S.R., Danley D.E., Dipesa A.J., Donahue K.M. et al. J. Med. Chem. 48:5728-5737(2005) · Mapped (1) |
| Potent pyrimidinetrione-based inhibitors of MMP-13 with enhanced selectivity over MMP-14. Blagg J.A., Noe M.C., Wolf-Gouveia L.A., Reiter L.A., Laird E.R., Chang S.P., Danley D.E., Downs J.T., Elliott N.C., Eskra J.D. et al. Bioorg. Med. Chem. Lett. 15:1807-1810(2005) · Mapped (1) |
| 3-(2-carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid: an allosteric inhibitor of fructose-1,6-bisphosphatase at the AMP site. Wright S.W., Carlo A.A., Danley D.E., Hageman D.L., Karam G.A., Mansour M.N., McClure L.D., Pandit J., Schulte G.K., Treadway J.L. et al. Bioorg. Med. Chem. Lett. 13:2055-2058(2003) · Mapped (1) |
| Discovery of a novel series of 6-azauracil-based thyroid hormone receptor ligands: potent, TR beta subtype-selective thyromimetics. Dow R.L., Schneider S.R., Paight E.S., Hank R.F., Chiang P., Cornelius P., Lee E., Newsome W.P., Swick A.G., Spitzer J. et al. Bioorg. Med. Chem. Lett. 13:379-382(2003) · Mapped (1) |
| Anilinoquinazoline inhibitors of fructose 1,6-bisphosphatase bind at a novel allosteric site: synthesis, in vitro characterization, and X-ray crystallography. Wright S.W., Carlo A.A., Carty M.D., Danley D.E., Hageman D.L., Karam G.A., Levy C.B., Mansour M.N., Mathiowetz A.M., McClure L.D. et al. J. Med. Chem. 45:3865-3877(2002) · Mapped (1) |
| Activation of human liver glycogen phosphorylase by alteration of the secondary structure and packing of the catalytic core. Rath V.L., Ammirati M., LeMotte P.K., Fennell K.F., Mansour M.N., Danley D.E., Hynes T.R., Schulte G.K., Wasilko D.J., Pandit J. Mol. Cell 6:139-148(2000) · UniProtKB (1) |
| Crystal structure of human squalene synthase. A key enzyme in cholesterol biosynthesis. Pandit J., Danley D.E., Schulte G.K., Mazzalupo S., Pauly T.A., Hayward C.M., Hamanaka E.S., Thompson J.F., Harwood H.J. Jr. J. Biol. Chem. 275:30610-30617(2000) · UniProtKB (1) · Mapped (2) |
| Identification, characterization, and crystal structure of the Omega class glutathione transferases. Board P.G., Coggan M., Chelvanayagam G., Easteal S., Jermiin L.S., Schulte G.K., Danley D.E., Hoth L.R., Griffor M.C., Kamath A.V. et al. J. Biol. Chem. 275:24798-24806(2000) · UniProtKB (1) · Mapped (3) |
| High-resolution structures of the ligand binding domain of the wild-type bacterial aspartate receptor. Yeh J.I., Biemann H.-P., Prive G.G., Pandit J., Koshland D.E. Jr., Kim S.-H. J. Mol. Biol. 262:186-201(1996) · UniProtKB (1) |
| Three-dimensional structures of the periplasmic lysine/arginine/ornithine-binding protein with and without a ligand. Oh B.-H., Pandit J., Kang C.-H., Nikaido K., Gokcen S., Ames G.F.-L., Kim S.-H. J. Biol. Chem. 268:11348-11355(1993) · UniProtKB (1) |
| The three-dimensional structure of the ligand-binding domain of a wild-type bacterial chemotaxis receptor. Structural comparison to the cross-linked mutant forms and conformational changes upon ligand binding. Yeh J.I., Biemann H.-P., Pandit J., Koshland D.E. Jr., Kim S.-H. J. Biol. Chem. 268:9787-9792(1993) · UniProtKB (1) |
| Three-dimensional structure of dimeric human recombinant macrophage colony-stimulating factor. Pandit J., Bohm A., Jancarik J., Halenbeck R., Koths K., Kim S.H. Science 258:1358-1362(1992) · UniProtKB (1) |