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Induction of the stem-like cell regulator CD44 by Rho kinase inhibition contributes to the maintenance of colon cancer-initiating cells.

Ohata H., Ishiguro T., Aihara Y., Sato A., Sakai H., Sekine S., Taniguchi H., Akasu T., Fujita S., Nakagama H. et al.

Cancer Res. 72:5101-5110(2012) · Mapped (6)

The tail nick augments Aeromonas sobria serine protease (ASP) activity in plasma through retarding inhibition by alpha2-macroglobulin.

Murakami Y., Wada Y., Kobayashi H., Hasegawa M., Okamoto K., Eto M., Imamura T.

FEBS Lett. 586:3613-3617(2012) · Mapped (2)

Modulation of lipid metabolism with the overexpression of NPC1L1 in mouse liver.

Kurano M., Hara M., Tsuneyama K., Okamoto K., Iso-O N., Matsushima T., Koike K., Tsukamoto K.

J. Lipid Res. 53:2275-2285(2012) · Mapped (13)

Thrombosis from a prothrombin mutation conveying antithrombin resistance.

Miyawaki Y., Suzuki A., Fujita J., Maki A., Okuyama E., Murata M., Takagi A., Murate T., Kunishima S., Sakai M. et al.

N. Engl. J. Med. 366:2390-2396(2012) · Mapped (8)

Angiotensin II enhances epithelial-to-mesenchymal transition through the interaction between activated hepatic stellate cells and the stromal cell-derived factor-1/CXCR4 axis in intrahepatic cholangiocarcinoma.

Okamoto K., Tajima H., Nakanuma S., Sakai S., Makino I., Kinoshita J., Hayashi H., Nakamura K., Oyama K., Nakagawara H. et al.

Int. J. Oncol. 41:573-582(2012) · Mapped (11)

Inhibition of glucose-stimulated insulin secretion by KCNJ15, a newly identified susceptibility gene for type 2 diabetes.

Okamoto K., Iwasaki N., Doi K., Noiri E., Iwamoto Y., Uchigata Y., Fujita T., Tokunaga K.

Diabetes 61:1734-1741(2012) · Mapped (11)

Macrophage-derived angiopoietin-like protein 2 accelerates development of abdominal aortic aneurysm.

Tazume H., Miyata K., Tian Z., Endo M., Horiguchi H., Takahashi O., Horio E., Tsukano H., Kadomatsu T., Nakashima Y. et al.

Arterioscler. Thromb. Vasc. Biol. 32:1400-1409(2012) · Mapped (4)

3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor simvastatin ameliorates renal fibrosis through HOXA13-USAG-1 pathway.

Hamasaki Y., Doi K., Okamoto K., Ijichi H., Seki G., Maeda-Mamiya R., Fujita T., Noiri E.

Lab. Invest. 92:1161-1170(2012) · Mapped (1)

The active stem cell specific expression of sponge Musashi homolog EflMsiA suggests its involvement in maintaining the stem cell state.

Okamoto K., Nakatsukasa M., Alie A., Masuda Y., Agata K., Funayama N.

Mech. Dev. 129:24-37(2012) · UniProtKB (2)

Reduced expression of BTBD10, an Akt activator, leads to motor neuron death.

Nawa M., Kage-Nakadai E., Aiso S., Okamoto K., Mitani S., Matsuoka M.

Cell Death Differ. 19:1398-1407(2012) · Mapped (8)

Rapid downregulation of cyclin D1 induced by geranylgeranoic acid in human hepatoma cells.

Shimonishi S., Muraguchi T., Mitake M., Sakane C., Okamoto K., Shidoji Y.

Nutr Cancer 64:473-480(2012) · Mapped (5)

Autophagy-related protein 32 acts as autophagic degron and directly initiates mitophagy.

Kondo-Okamoto N., Noda N.N., Suzuki S.W., Nakatogawa H., Takahashi I., Matsunami M., Hashimoto A., Inagaki F., Ohsumi Y., Okamoto K.

J. Biol. Chem. 287:10631-10638(2012) · UniProtKB (1) · Mapped (2)

Comparison of phosphorylated TDP-43-positive inclusions in oculomotor neurons in patients with non-ALS and ALS disorders.

Mizuno Y., Fujita Y., Takatama M., Okamoto K.

J. Neurol. Sci. 315:20-25(2012) · Mapped (5)

Microregional antitumor activity of a small-molecule hypoxia-inducible factor 1 inhibitor.

Okamoto K., Ito D., Miyazaki K., Watanabe S., Tohyama O., Yokoi A., Ozawa Y., Asano M., Kawamura T., Yamane Y. et al.

Int. J. Mol. Med. 29:541-549(2012) · Mapped (3)

Dengue virus strain DEN2 16681 utilizes a specific glycochain of syndecan-2 proteoglycan as a receptor.

Okamoto K., Kinoshita H., Parquet M.d.e.l. C., Raekiansyah M., Kimura D., Yui K., Islam M.A., Hasebe F., Morita K.

J. Gen. Virol. 93:761-770(2012) · Mapped (4)

Protein conformational gating of enzymatic activity in xanthine oxidoreductase.

Ishikita H., Eger B.T., Okamoto K., Nishino T., Pai E.F.

J. Am. Chem. Soc. 134:999-1009(2012) · Mapped (1)

Role of the transcription factor Sp1 in regulating the expression of the murine cathepsin E gene.

Okamoto K., Okamoto Y., Kawakubo T., Iwata J., Yasuda Y., Tsukuba T., Yamamoto K.

J. Biochem. 151:263-272(2012) · Mapped (4)

Differential expression of nanog1 and nanogp8 in colon cancer cells.

Ishiguro T., Sato A., Ohata H., Sakai H., Nakagama H., Okamoto K.

Biochem. Biophys. Res. Commun. 418:199-204(2012) · Mapped (3)

Overcoming erlotinib resistance in EGFR mutation-positive non-small cell lung cancer cells by targeting survivin.

Okamoto K., Okamoto I., Hatashita E., Kuwata K., Yamaguchi H., Kita A., Yamanaka K., Ono M., Nakagawa K.

Mol. Cancer Ther. 11:204-213(2012) · Mapped (31)

Increased expression of S100 calcium binding protein A8 in GM-CSF-stimulated neutrophils leads to the increased expressions of IL-8 and IL-16.

Katano M., Okamoto K., Suematsu N., Kurokawa M.S., Nakamura H., Masuko K., Yudoh K., Kato T.

Clin. Exp. Rheumatol. 29:768-775(2011) · Mapped (7)

Different clinical and neuropathologic phenotypes of familial ALS with A315E TARDBP mutation.

Fujita Y., Ikeda M., Yanagisawa T., Senoo Y., Okamoto K.

Neurology 77:1427-1431(2011) · Mapped (5)

Discovery of the first insect nidovirus, a missing evolutionary link in the emergence of the largest RNA virus genomes.

Nga P.T., Parquet M.d.e.l. C., Lauber C., Parida M., Nabeshima T., Yu F., Thuy N.T., Inoue S., Ito T., Okamoto K. et al.

PLoS Pathog. 7:e1002215-e1002215(2011) · UniProtKB (6)

MET tyrosine kinase inhibitor crizotinib (PF-02341066) shows differential antitumor effects in non-small cell lung cancer according to MET alterations.

Tanizaki J., Okamoto I., Okamoto K., Takezawa K., Kuwata K., Yamaguchi H., Nakagawa K.

J Thorac Oncol 6:1624-1631(2011) · Mapped (22)

The role of the BH3-only protein Noxa in bone homeostasis.

Idrus E., Nakashima T., Wang L., Hayashi M., Okamoto K., Kodama T., Tanaka N., Taniguchi T., Takayanagi H.

Biochem. Biophys. Res. Commun. 410:620-625(2011) · Mapped (1)

Arthritogenicity of annexin VII revealed by phosphoproteomics of rheumatoid synoviocytes.

Matsuo K., Arito M., Noyori K., Nakamura H., Kurokawa M.S., Masuko K., Okamoto K., Nagai K., Suematsu N., Yudoh K. et al.

Ann. Rheum. Dis. 70:1489-1495(2011) · Mapped (7)

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