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Early growth response 1 loops the CYP2B6 promoter for synergistic activation by the distal and proximal nuclear receptors CAR and HNF4alpha.

Inoue K., Negishi M.

FEBS Lett. 583:2126-2130(2009) · Mapped (18)

Plexin-B1 is a GTPase activating protein for M-Ras, remodelling dendrite morphology.

Saito Y., Oinuma I., Fujimoto S., Negishi M.

EMBO Rep. 10:614-621(2009) · Mapped (7)

Beta2-chimaerin binds to EphA receptors and regulates cell migration.

Takeuchi S., Yamaki N., Iwasato T., Negishi M., Katoh H.

FEBS Lett. 583:1237-1242(2009) · Mapped (25)

Regulation of dendrite growth by the Cdc42 activator Zizimin1/Dock9 in hippocampal neurons.

Kuramoto K., Negishi M., Katoh H.

J. Neurosci. Res. 87:1794-1805(2009) · Mapped (7)

Different requirement for Rnd GTPases of R-Ras GAP activity of Plexin-C1 and Plexin-D1.

Uesugi K., Oinuma I., Katoh H., Negishi M.

J. Biol. Chem. 284:6743-6751(2009) · Mapped (14)

Lysophosphatidic acid and thrombin receptors require both G alpha12 and G alpha13 to regulate axonal morphology in hippocampal neurons.

Yamazaki J., Katoh H., Negishi M.

Biol. Pharm. Bull. 31:2216-2222(2008) · Mapped (2)

2-o-phosphorylation of xylose and 6-o-sulfation of galactose in the protein linkage region of glycosaminoglycans influence the glucuronyltransferase-I activity involved in the linkage region synthesis.

Tone Y., Pedersen L.C., Yamamoto T., Izumikawa T., Kitagawa H., Nishihara J., Tamura J., Negishi M., Sugahara K.

J. Biol. Chem. 283:16801-16807(2008) · Mapped (4)

Expression of CAR in SW480 and HepG2 cells during G1 is associated with cell proliferation.

Osabe M., Sugatani J., Takemura A., Yamazaki Y., Ikari A., Kitamura N., Negishi M., Miwa M.

Biochem. Biophys. Res. Commun. 369:1027-1033(2008) · Mapped (25)

The roles of nuclear receptors CAR and PXR in hepatic energy metabolism.

Konno Y., Negishi M., Kodama S.

Drug Metab. Pharmacokinet. 23:8-13(2008) · Mapped (30)

Nuclear receptor CAR requires early growth response 1 to activate the human cytochrome P450 2B6 gene.

Inoue K., Negishi M.

J. Biol. Chem. 283:10425-10432(2008) · Mapped (34)

PPP1R16A, the membrane subunit of protein phosphatase 1beta, signals nuclear translocation of the nuclear receptor constitutive active/androstane receptor.

Sueyoshi T., Moore R., Sugatani J., Matsumura Y., Negishi M.

Mol. Pharmacol. 73:1113-1121(2008) · Mapped (29)

Plexin-B1 mutations in prostate cancer.

Wong O.G., Nitkunan T., Oinuma I., Zhou C., Blanc V., Brown R.S., Bott S.R., Nariculam J., Box G., Munson P. et al.

Proc. Natl. Acad. Sci. U.S.A. 104:19040-19045(2007) · Mapped (6)

Overexpression of the Rho-guanine nucleotide exchange factor ECT2 inhibits nuclear translocation of nuclear receptor CAR in the mouse liver.

Hosseinpour F., Timsit Y., Koike C., Matsui K., Yamamoto Y., Moore R., Negishi M.

FEBS Lett. 581:4937-4942(2007) · Mapped (5)

Rac-GAP alpha-chimerin regulates motor-circuit formation as a key mediator of EphrinB3/EphA4 forward signaling.

Iwasato T., Katoh H., Nishimaru H., Ishikawa Y., Inoue H., Saito Y.M., Ando R., Iwama M., Takahashi R., Negishi M. et al.

Cell 130:742-753(2007) · UniProtKB (3) · Mapped (9)

Human nuclear pregnane X receptor cross-talk with CREB to repress cAMP activation of the glucose-6-phosphatase gene.

Kodama S., Moore R., Yamamoto Y., Negishi M.

Biochem. J. 407:373-381(2007) · Mapped (5)

RhoG regulates anoikis through a phosphatidylinositol 3-kinase-dependent mechanism.

Yamaki N., Negishi M., Katoh H.

Exp. Cell Res. 313:2821-2832(2007) · Mapped (7)

Extracellular signal-regulated kinase is an endogenous signal retaining the nuclear constitutive active/androstane receptor (CAR) in the cytoplasm of mouse primary hepatocytes.

Koike C., Moore R., Negishi M.

Mol. Pharmacol. 71:1217-1221(2007) · Mapped (6)

Nuclear pregnane X receptor cross-talk with FoxA2 to mediate drug-induced regulation of lipid metabolism in fasting mouse liver.

Nakamura K., Moore R., Negishi M., Sueyoshi T.

J. Biol. Chem. 282:9768-9776(2007) · Mapped (3)

Bmi1 cooperates with Dnmt1-associated protein 1 in gene silencing.

Negishi M., Saraya A., Miyagi S., Nagao K., Inagaki Y., Nishikawa M., Tajima S., Koseki H., Tsuda H., Takasaki Y. et al.

Biochem. Biophys. Res. Commun. 353:992-998(2007) · Mapped (3)

R-Ras controls axon specification upstream of glycogen synthase kinase-3beta through integrin-linked kinase.

Oinuma I., Katoh H., Negishi M.

J. Biol. Chem. 282:303-318(2007) · Mapped (7)

Dock4 is regulated by RhoG and promotes Rac-dependent cell migration.

Hiramoto K., Negishi M., Katoh H.

Exp. Cell Res. 312:4205-4216(2006) · Mapped (15)

The role of the nuclear receptor constitutive androstane receptor in the pathogenesis of non-alcoholic steatohepatitis.

Yamazaki Y., Kakizaki S., Horiguchi N., Sohara N., Sato K., Takagi H., Mori M., Negishi M.

Gut 56:565-574(2007) · Mapped (5)

Regulation of neuronal morphology by Toca-1, an F-BAR/EFC protein that induces plasma membrane invagination.

Kakimoto T., Katoh H., Negishi M.

J. Biol. Chem. 281:29042-29053(2006) · UniProtKB (1) · Mapped (11)

PKC phosphorylates MARCKS Ser159 not only directly but also through RhoA/ROCK.

Tanabe A., Kamisuki Y., Hidaka H., Suzuki M., Negishi M., Takuwa Y.

Biochem. Biophys. Res. Commun. 345:156-161(2006) · Mapped (3)

Cohesin protein SMC1 represses the nuclear receptor CAR-mediated synergistic activation of a human P450 gene by xenobiotics.

Inoue K., Borchers C.H., Negishi M.

Biochem. J. 398:125-133(2006) · Mapped (13)

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