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A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora B.

De Antoni A., Maffini S., Knapp S., Musacchio A., Santaguida S.

J. Cell Biol. 199:269-284(2012)

Crystal structure of human aurora B in complex with INCENP and VX-680.

Elkins J.M., Santaguida S., Musacchio A., Knapp S.

J. Med. Chem. 55:7841-7848(2012) · Mapped (2)

Structural analysis reveals features of the spindle checkpoint kinase Bub1-kinetochore subunit Knl1 interaction.

Krenn V., Wehenkel A., Li X., Santaguida S., Musacchio A.

J. Cell Biol. 196:451-467(2012) · Mapped (16)

Selective aurora kinase inhibitors identified using a taxol-induced checkpoint sensitivity screen.

Kwiatkowski N., Deng X., Wang J., Tan L., Villa F., Santaguida S., Huang H.C., Mitchison T., Musacchio A., Gray N.

ACS Chem. Biol. 7:185-196(2012) · Mapped (2)

Structure of the HECT:ubiquitin complex and its role in ubiquitin chain elongation.

Maspero E., Mari S., Valentini E., Musacchio A., Fish A., Pasqualato S., Polo S.

EMBO Rep. 12:342-349(2011) · UniProtKB (1) · Mapped (1)

Direct binding of Cenp-C to the Mis12 complex joins the inner and outer kinetochore.

Screpanti E., De Antoni A., Alushin G.M., Petrovic A., Melis T., Nogales E., Musacchio A.

Curr. Biol. 21:391-398(2011) · Mapped (5)

Abnormal kinetochore-generated pulling forces from expressing a N-terminally modified Hec1.

Mattiuzzo M., Vargiu G., Totta P., Fiore M., Ciferri C., Musacchio A., Degrassi F.

PLoS ONE 6:e16307-e16307(2011) · Mapped (3)

The Ndc80 loop region facilitates formation of kinetochore attachment to the dynamic microtubule plus end.

Maure J.F., Komoto S., Oku Y., Mino A., Pasqualato S., Natsume K., Clayton L., Musacchio A., Tanaka T.U.

Curr. Biol. 21:207-213(2011) · Mapped (4)

The Ndc80 kinetochore complex forms oligomeric arrays along microtubules.

Alushin G.M., Ramey V.H., Pasqualato S., Ball D.A., Grigorieff N., Musacchio A., Nogales E.

Nature 467:805-810(2010) · Mapped (3)

Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine.

Santaguida S., Tighe A., D'Alise A.M., Taylor S.S., Musacchio A.

J. Cell Biol. 190:73-87(2010) · Mapped (1)

Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1-C-Mad2 core complex.

Hewitt L., Tighe A., Santaguida S., White A.M., Jones C.D., Musacchio A., Green S., Taylor S.S.

J. Cell Biol. 190:25-34(2010) · Mapped (6)

Structural analysis of the RZZ complex reveals common ancestry with multisubunit vesicle tethering machinery.

Civril F., Wehenkel A., Giorgi F.M., Santaguida S., Di Fonzo A., Grigorean G., Ciccarelli F.D., Musacchio A.

Structure 18:616-626(2010) · UniProtKB (1)

Crystal structure of the catalytic domain of Haspin, an atypical kinase implicated in chromatin organization.

Villa F., Capasso P., Tortorici M., Forneris F., de Marco A., Mattevi A., Musacchio A.

Proc. Natl. Acad. Sci. U.S.A. 106:20204-20209(2009) · UniProtKB (1)

The C-terminal domain of CENP-C displays multiple and critical functions for mammalian centromere formation.

Trazzi S., Perini G., Bernardoni R., Zoli M., Reese J.C., Musacchio A., Della Valle G.

PLoS ONE 4:E5832-E5832(2009) · UniProtKB (2) · Mapped (2)

The influence of catalysis on mad2 activation dynamics.

Simonetta M., Manzoni R., Mosca R., Mapelli M., Massimiliano L., Vink M., Novak B., Musacchio A., Ciliberto A.

PLoS Biol. 7:e10-e10(2009) · Mapped (2)

The Aurora B kinase activity is required for the maintenance of the differentiated state of murine myoblasts.

Amabile G., D'Alise A.M., Iovino M., Jones P., Santaguida S., Musacchio A., Taylor S., Cortese R.

Cell Death Differ. 16:321-330(2009) · Mapped (4)

Molecular basis of drug resistance in aurora kinases.

Girdler F., Sessa F., Patercoli S., Villa F., Musacchio A., Taylor S.

Chem. Biol. 15:552-562(2008) · Mapped (2)

Reversine, a novel Aurora kinases inhibitor, inhibits colony formation of human acute myeloid leukemia cells.

D'Alise A.M., Amabile G., Iovino M., Di Giorgio F.P., Bartiromo M., Sessa F., Villa F., Musacchio A., Cortese R.

Mol. Cancer Ther. 7:1140-1149(2008) · Mapped (2)

Implications for kinetochore-microtubule attachment from the structure of an engineered Ndc80 complex.

Ciferri C., Pasqualato S., Screpanti E., Varetti G., Santaguida S., Dos Reis G., Maiolica A., Polka J., De Luca J.G., De Wulf P. et al.

Cell 133:427-439(2008) · Mapped (6)

Discovery of selective aminothiazole aurora kinase inhibitors.

Andersen C.B., Wan Y., Chang J.W., Riggs B., Lee C., Liu Y., Sessa F., Villa F., Kwiatkowski N., Suzuki M. et al.

ACS Chem. Biol. 3:180-192(2008) · Mapped (2)

The Mad2 conformational dimer: structure and implications for the spindle assembly checkpoint.

Mapelli M., Massimiliano L., Santaguida S., Musacchio A.

Cell 131:730-743(2007) · UniProtKB (1) · Mapped (1)

The structure of the coiled-coil domain of Ndel1 and the basis of its interaction with Lis1, the causal protein of Miller-Dieker lissencephaly.

Derewenda U., Tarricone C., Choi W.C., Cooper D.R., Lukasik S., Perrina F., Tripathy A., Kim M.H., Cafiso D.S., Musacchio A. et al.

Structure 15:1467-1481(2007) · Mapped (4)

The Ndc80 complex: hub of kinetochore activity.

Ciferri C., Musacchio A., Petrovic A.

FEBS Lett. 581:2862-2869(2007) · Mapped (4)

Kinetochore microtubule dynamics and attachment stability are regulated by Hec1.

DeLuca J.G., Gall W.E., Ciferri C., Cimini D., Musacchio A., Salmon E.D.

Cell 127:969-982(2006) · Mapped (3)

Accumulation of Mad2-Cdc20 complex during spindle checkpoint activation requires binding of open and closed conformers of Mad2 in Saccharomyces cerevisiae.

Nezi L., Rancati G., De Antoni A., Pasqualato S., Piatti S., Musacchio A.

J. Cell Biol. 174:39-51(2006) · Mapped (3)

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