| Alpha-synuclein aggregation involves a bafilomycin A 1-sensitive autophagy pathway. Klucken J., Poehler A.M., Ebrahimi-Fakhari D., Schneider J., Nuber S., Rockenstein E., Schlotzer-Schrehardt U., Hyman B.T., McLean P.J., Masliah E. et al.
Autophagy 8:754-766(2012) · Mapped (7) |
| SIRT1 protects against alpha-synuclein aggregation by activating molecular chaperones. Donmez G., Arun A., Chung C.Y., McLean P.J., Lindquist S., Guarente L.
J. Neurosci. 32:124-132(2012) · Mapped (8) |
| Distinct roles in vivo for the ubiquitin-proteasome system and the autophagy-lysosomal pathway in the degradation of alpha-synuclein. Ebrahimi-Fakhari D., Cantuti-Castelvetri I., Fan Z., Rockenstein E., Masliah E., Hyman B.T., McLean P.J., Unni V.K.
J. Neurosci. 31:14508-14520(2011) · Mapped (7) |
| Gaucher disease glucocerebrosidase and alpha-synuclein form a bidirectional pathogenic loop in synucleinopathies. Mazzulli J.R., Xu Y.H., Sun Y., Knight A.L., McLean P.J., Caldwell G.A., Sidransky E., Grabowski G.A., Krainc D.
Cell 146:37-52(2011) · Mapped (30) |
| Ubiquitinylation of alpha-synuclein by carboxyl terminus Hsp70-interacting protein (CHIP) is regulated by Bcl-2-associated athanogene 5 (BAG5). Kalia L.V., Kalia S.K., Chau H., Lozano A.M., Hyman B.T., McLean P.J.
PLoS ONE 6:e14695-e14695(2011) · Mapped (10) |
| Heat-shock protein 70 modulates toxic extracellular alpha-synuclein oligomers and rescues trans-synaptic toxicity. Danzer K.M., Ruf W.P., Putcha P., Joyner D., Hashimoto T., Glabe C., Hyman B.T., McLean P.J.
FASEB J. 25:326-336(2011) · Mapped (23) |
| In vivo imaging of alpha-synuclein in mouse cortex demonstrates stable expression and differential subcellular compartment mobility. Unni V.K., Weissman T.A., Rockenstein E., Masliah E., McLean P.J., Hyman B.T.
PLoS ONE 5:e10589-e10589(2010) · Mapped (1) |
| Tyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation. Chen L., Periquet M., Wang X., Negro A., McLean P.J., Hyman B.T., Feany M.B.
J. Clin. Invest. 119:3257-3265(2009) · Mapped (8) |
| Targeted overexpression of human alpha-synuclein triggers microglial activation and an adaptive immune response in a mouse model of Parkinson disease. Theodore S., Cao S., McLean P.J., Standaert D.G.
J. Neuropathol. Exp. Neurol. 67:1149-1158(2008) · Mapped (7) |
| Direct quantification of CSF alpha-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration. Mollenhauer B., Cullen V., Kahn I., Krastins B., Outeiro T.F., Pepivani I., Ng J., Schulz-Schaeffer W., Kretzschmar H.A., McLean P.J. et al.
Exp. Neurol. 213:315-325(2008) · Mapped (7) |
| CHIP targets toxic alpha-Synuclein oligomers for degradation. Tetzlaff J.E., Putcha P., Outeiro T.F., Ivanov A., Berezovska O., Hyman B.T., McLean P.J.
J. Biol. Chem. 283:17962-17968(2008) · Mapped (1) |
| Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease. Outeiro T.F., Kontopoulos E., Altmann S.M., Kufareva I., Strathearn K.E., Amore A.M., Volk C.B., Maxwell M.M., Rochet J.C., McLean P.J. et al.
Science 317:516-519(2007) · Mapped (1) |
| Detection of novel intracellular alpha-synuclein oligomeric species by fluorescence lifetime imaging. Klucken J., Outeiro T.F., Nguyen P., McLean P.J., Hyman B.T.
FASEB J. 20:2050-2057(2006) · Mapped (23) |
| The co-chaperone carboxyl terminus of Hsp70-interacting protein (CHIP) mediates alpha-synuclein degradation decisions between proteasomal and lysosomal pathways. Shin Y., Klucken J., Patterson C., Hyman B.T., McLean P.J.
J. Biol. Chem. 280:23727-23734(2005) · Mapped (16) |
| A single amino acid substitution differentiates Hsp70-dependent effects on alpha-synuclein degradation and toxicity. Klucken J., Shin Y., Hyman B.T., McLean P.J.
Biochem. Biophys. Res. Commun. 325:367-373(2004) · Mapped (7) |
| Mapping of the alpha 4 subunit gene (GABRA4) to human chromosome 4 defines an alpha 2-alpha 4-beta 1-gamma 1 gene cluster: further evidence that modern GABAA receptor gene clusters are derived from an ancestral cluster. McLean P.J., Farb D.H., Russek S.J.
Genomics 26:580-586(1995) · UniProtKB (1) |
