1 - 25 of 27 results for author:"McLean K." in Literature citations
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| Application of fragment screening and merging to the discovery of inhibitors of the Mycobacterium tuberculosis cytochrome P450 CYP121. Hudson S.A., McLean K.J., Surade S., Yang Y.Q., Leys D., Ciulli A., Munro A.W., Abell C. Angew. Chem. Int. Ed. Engl. 51:9311-9316(2012) · Mapped (1) |
| Unusual spectroscopic and ligand binding properties of the cytochrome P450-flavodoxin fusion enzyme XplA. Bui S.H., McLean K.J., Cheesman M.R., Bradley J.M., Rigby S.E., Levy C.W., Leys D., Munro A.W. J. Biol. Chem. 287:19699-19714(2012) · UniProtKB (1) |
| Wnt5a is strongly expressed at the leading edge in non-melanoma skin cancer, forming active gradients, while canonical Wnt signalling is repressed. Pourreyron C., Reilly L., Proby C., Panteleyev A., Fleming C., McLean K., South A.P., Foerster J. PLoS ONE 7:e31827-e31827(2012) · Mapped (4) |
| The in vivo performance of an enzyme-assisted self-assembled peptide/protein hydrogel. Williams R.J., Hall T.E., Glattauer V., White J., Pasic P.J., Sorensen A.B., Waddington L., McLean K.M., Currie P.D., Hartley P.G. Biomaterials 32:5304-5310(2011) · Mapped (4) |
| FdC1, a novel ferredoxin protein capable of alternative electron partitioning, increases in conditions of acceptor limitation at photosystem I. Voss I., Goss T., Murozuka E., Altmann B., McLean K.J., Rigby S.E., Munro A.W., Scheibe R., Hase T., Hanke G.T. J. Biol. Chem. 286:50-59(2011) · Mapped (1) |
| Structural and biochemical characterization of Mycobacterium tuberculosis CYP142: evidence for multiple cholesterol 27-hydroxylase activities in a human pathogen. Driscoll M.D., McLean K.J., Levy C., Mast N., Pikuleva I.A., Lafite P., Rigby S.E., Leys D., Munro A.W. J. Biol. Chem. 285:38270-38282(2010) · Mapped (1) |
| Expression and characterization of Mycobacterium tuberculosis CYP144: common themes and lessons learned in the M. tuberculosis P450 enzyme family. Driscoll M.D., McLean K.J., Cheesman M.R., Jowitt T.A., Howard M., Carroll P., Parish T., Munro A.W. Biochim. Biophys. Acta 1814:76-87(2011) · UniProtKB (1) |
| The Rho guanine nucleotide exchange factor AKAP13 (BRX) is essential for cardiac development in mice. Mayers C.M., Wadell J., McLean K., Venere M., Malik M., Shibata T., Driggers P.H., Kino T., Guo X.C., Koide H. et al. J. Biol. Chem. 285:12344-12354(2010) · Mapped (40) |
| The Structure of Mycobacterium tuberculosis CYP125: molecular basis for cholesterol binding in a P450 needed for host infection. McLean K.J., Lafite P., Levy C., Cheesman M.R., Mast N., Pikuleva I.A., Leys D., Munro A.W. J. Biol. Chem. 284:35524-35533(2009) · UniProtKB (1) |
| Placental IL-10 dysregulation and association with bronchopulmonary dysplasia risk. McGowan E.C., Kostadinov S., McLean K., Gotsch F., Venturini D., Romero R., Laptook A.R., Sharma S. Pediatr. Res. 66:455-460(2009) · Mapped (7) |
| Wnt5a exhibits layer-specific expression in adult skin, is upregulated in psoriasis, and synergizes with type 1 interferon. Romanowska M., Evans A., Kellock D., Bray S.E., McLean K., Donandt S., Foerster J. PLoS ONE 4:e5354-e5354(2009) · Mapped (4) |
| Characterization of active site structure in CYP121. A cytochrome P450 essential for viability of Mycobacterium tuberculosis H37Rv. McLean K.J., Carroll P., Lewis D.G., Dunford A.J., Seward H.E., Neeli R., Cheesman M.R., Marsollier L., Douglas P., Smith W.E. et al. J. Biol. Chem. 283:33406-33416(2008) · Mapped (1) |
| Identification, characterization, and structure/function analysis of a corrin reductase involved in adenosylcobalamin biosynthesis. Lawrence A.D., Deery E., McLean K.J., Munro A.W., Pickersgill R.W., Rigby S.E., Warren M.J. J. Biol. Chem. 283:10813-10821(2008) · UniProtKB (1) |
| Crystal structure of the Mycobacterium tuberculosis P450 CYP121-fluconazole complex reveals new azole drug-P450 binding mode. Seward H.E., Roujeinikova A., McLean K.J., Munro A.W., Leys D. J. Biol. Chem. 281:39437-39443(2006) · Mapped (1) |
| Eukaryotic expression of recombinant Pso o 1, an allergen from Psoroptes ovis, and its localization in the mite. Nisbet A.J., MacKellar A., McLean K., Brennan G.P., Huntley J.F. Parasitology 134:83-89(2007) · UniProtKB (1) |
| Biophysical characterization of the sterol demethylase P450 from Mycobacterium tuberculosis, its cognate ferredoxin, and their interactions. McLean K.J., Warman A.J., Seward H.E., Marshall K.R., Girvan H.M., Cheesman M.R., Waterman M.R., Munro A.W. Biochemistry 45:8427-8443(2006) |
| Methylation-independent binding to histone H3 and cell cycle-dependent incorporation of HP1beta into heterochromatin. Dialynas G.K., Makatsori D., Kourmouli N., Theodoropoulos P.A., McLean K., Terjung S., Singh P.B., Georgatos S.D. J. Biol. Chem. 281:14350-14360(2006) · Mapped (6) |
| Inhibition of p38 reduces myocardial infarction injury in the mouse but not pig after ischemia-reperfusion. Kaiser R.A., Lyons J.M., Duffy J.Y., Wagner C.J., McLean K.M., O'Neill T.P., Pearl J.M., Molkentin J.D. Am. J. Physiol. Heart Circ. Physiol. 289:H2747-51(2005) · Mapped (3) |
| The discovery of fluoropyridine-based inhibitors of the Factor VIIa/TF complex. Kohrt J.T., Filipski K.J., Cody W.L., Cai C., Dudley D.A., Van Huis C.A., Willardsen J.A., Rapundalo S.T., Saiya-Cork K., Leadley R.J. et al. Bioorg. Med. Chem. Lett. 15:4752-4756(2005) · Mapped (2) |
| Identification and characterization of the terminal enzyme of siroheme biosynthesis from Arabidopsis thaliana: a plastid-located sirohydrochlorin ferrochelatase containing a 2FE-2S center. Raux-Deery E., Leech H.K., Nakrieko K.A., McLean K.J., Munro A.W., Heathcote P., Rigby S.E., Smith A.G., Warren M.J. J. Biol. Chem. 280:4713-4721(2005) · Mapped (1) |
| Polymorphisms in BRCA1 and BRCA2 and risk of epithelial ovarian cancer. Wenham R.M., Schildkraut J.M., McLean K., Calingaert B., Bentley R.C., Marks J., Berchuck A. Clin. Cancer Res. 9:4396-4403(2003) · Mapped (18) |
| Characterization of the cobaltochelatase CbiXL: evidence for a 4Fe-4S center housed within an MXCXXC motif. Leech H.K., Raux E., McLean K.J., Munro A.W., Robinson N.J., Borrelly G.P.M., Malten M., Jahn D., Rigby S.E.J., Heathcote P. et al. J. Biol. Chem. 278:41900-41907(2003) · UniProtKB (2) |
| Kinetic, spectroscopic and thermodynamic characterization of the Mycobacterium tuberculosis adrenodoxin reductase homologue FprA. McLean K.J., Scrutton N.S., Munro A.W. Biochem. J. 372:317-327(2003) · UniProtKB (1) |
| Atomic structure of Mycobacterium tuberculosis CYP121 to 1.06 A reveals novel features of cytochrome P450. Leys D., Mowat C.G., McLean K.J., Richmond A., Chapman S.K., Walkinshaw M.D., Munro A.W. J. Biol. Chem. 278:5141-5147(2003) · UniProtKB (1) |
| Expression, purification and spectroscopic characterization of the cytochrome P450 CYP121 from Mycobacterium tuberculosis. McLean K.J., Cheesman M.R., Rivers S.L., Richmond A., Leys D., Chapman S.K., Reid G.A., Price N.C., Kelly S.M., Clarkson J. et al. J. Inorg. Biochem. 91:527-541(2002) · UniProtKB (1) |