| Structural conservation of an ancient tRNA sensor in eukaryotic glutaminyl-tRNA synthetase. Grant T.D., Snell E.H., Luft J.R., Quartley E., Corretore S., Wolfley J.R., Snell M.E., Hadd A., Perona J.J., Phizicky E.M. et al.
Nucleic Acids Res. 40:3723-3731(2012) · Mapped (1) |
| Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies. Arakaki T.L., Buckner F.S., Gillespie J.R., Malmquist N.A., Phillips M.A., Kalyuzhniy O., Luft J.R., DeTitta G.T., Verlinde C.L.M.J., Van Voorhis W.C. et al.
Mol. Microbiol. 68:37-50(2008) · UniProtKB (1) |
| Blocking S-adenosylmethionine synthesis in yeast allows selenomethionine incorporation and multiwavelength anomalous dispersion phasing. Malkowski M.G., Quartley E., Friedman A.E., Babulski J., Kon Y., Wolfley J., Said M., Luft J.R., Phizicky E.M., DeTitta G.T. et al.
Proc. Natl. Acad. Sci. U.S.A. 104:6678-6683(2007) · Mapped (4) |
| Using fragment cocktail crystallography to assist inhibitor design of Trypanosoma brucei nucleoside 2-deoxyribosyltransferase. Bosch J., Robien M.A., Mehlin C., Boni E., Riechers A., Buckner F.S., Van Voorhis W.C., Myler P.J., Worthey E.A., DeTitta G. et al.
J. Med. Chem. 49:5939-5946(2006) · UniProtKB (1) |
| Crystal structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum at 2.25 A resolution reveals intriguing extra electron density in the active site. Robien M.A., Bosch J., Buckner F.S., Van Voorhis W.C., Worthey E.A., Myler P., Mehlin C., Boni E.E., Kalyuzhniy O., Anderson L. et al.
Proteins 62:570-577(2006) · UniProtKB (1) |
| Structures of Plasmodium falciparum purine nucleoside phosphorylase complexed with sulfate and its natural substrate inosine. Schnick C., Robien M.A., Brzozowski A.M., Dodson E.J., Murshudov G.N., Anderson L., Luft J.R., Mehlin C., Hol W.G., Brannigan J.A. et al.
Acta Crystallogr. D Biol. Crystallogr. 61:1245-1254(2005) · UniProtKB (1) |
| Understanding the role of Leu22 variants in methotrexate resistance: comparison of wild-type and Leu22Arg variant mouse and human dihydrofolate reductase ternary crystal complexes with methotrexate and NADPH. Cody V., Luft J.R., Pangborn W.
Acta Crystallogr. D 61:147-155(2005) · UniProtKB (2) |
| Comparison of ternary complexes of Pneumocystis carinii and wild-type human dihydrofolate reductase with coenzyme NADPH and a novel classical antitumor furo[2,3-d]pyrimidine antifolate. Cody V., Galitsky N., Luft J.R., Pangborn W., Gangjee A., Devraj R., Queener S.F., Blakley R.L.
Acta Crystallogr. D Biol. Crystallogr. 53:638-649(1997) · Mapped (1) |
| Structures of human transthyretin complexed with thyroxine at 2.0 A resolution and 3',5'-dinitro-N-acetyl-L-thyronine at 2.2 A resolution. Wojtczak A., Cody V., Luft J.R., Pangborn W.
Acta Crystallogr. D Biol. Crystallogr. 52:758-765(1996) · Mapped (1) |
| Structure determination of tetrahydroquinazoline antifolates in complex with human and Pneumocystis carinii dihydrofolate reductase: correlations between enzyme selectivity and stereochemistry. Cody V., Luft J.R., Pangborn W., Gangjee A., Queener S.F.
Acta Crystallogr. D 60:646-655(2004) · UniProtKB (2) |
| Analysis of three crystal structure determinations of a 5-methyl-6-N-methylanilino pyridopyrimidine antifolate complex with human dihydrofolate reductase. Cody V., Luft J.R., Pangborn W., Gangjee A.
Acta Crystallogr. D 59:1603-1609(2003) · UniProtKB (1) |
| Analysis of two polymorphic forms of a pyrido[2,3-d]pyrimidine N9-C10 reversed-bridge antifolate binary complex with human dihydrofolate reductase. Cody V., Galitsky N., Luft J.R., Pangborn W., Gangjee A.
Acta Crystallogr. D 59:654-661(2003) · UniProtKB (1) |
| Analysis of quinazoline and pyrido[2,3-d]pyrimidine N9-C10 reversed-bridge antifolates in complex with NADP+ and Pneumocystis carinii dihydrofolate reductase. Cody V., Galitsky N., Luft J.R., Pangborn W., Queener S.F., Gangjee A.
Acta Crystallogr. D 58:1393-1399(2002) · UniProtKB (1) |
| Structure-based enzyme inhibitor design: modeling studies and crystal structure analysis of Pneumocystis carinii dihydrofolate reductase ternary complex with PT653 and NADPH. Cody V., Galitsky N., Luft J.R., Pangborn W., Rosowsky A., Queener S.F.
Acta Crystallogr. D 58:946-954(2002) · UniProtKB (1) |
| Complex of rat transthyretin with tetraiodothyroacetic acid refined at 2.1 and 1.8 A resolution. Muziol T., Cody V., Luft J.R., Pangborn W., Wojtczak A.
Acta Biochim. Pol. 48:877-884(2001) · UniProtKB (1) |
| Structure of the insecticidal bacterial delta-endotoxin Cry3Bb1 of Bacillus thuringiensis. Galitsky N., Cody V., Wojtczak A., Ghosh D., Luft J.R., Pangborn W., English L.
Acta Crystallogr. D Biol. Crystallogr. 57:1101-1109(2001) · Mapped (1) |
| Structure of rat transthyretin (rTTR) complex with thyroxine at 2.5 A resolution: first non-biased insight into thyroxine binding reveals different hormone orientation in two binding sites. Wojtczak A., Cody V., Luft J.R., Pangborn W.
Acta Crystallogr. D Biol. Crystallogr. 57:1061-1070(2001) · Mapped (1) |
| Structural studies on bioactive compounds. 30. Crystal structure and molecular modeling studies on the Pneumocystis carinii dihydrofolate reductase cofactor complex with TAB, a highly selective antifolate. Cody V., Chan D., Galitsky N., Rak D., Luft J.R., Pangborn W., Queener S.F., Laughton C.A., Stevens M.F.
Biochemistry 39:3556-3564(2000) · UniProtKB (1) |
| Ligand-induced conformational changes in the crystal structures of Pneumocystis carinii dihydrofolate reductase complexes with folate and NADP+. Cody V., Galitsky N., Rak D., Luft J.R., Pangborn W., Queener S.F.
Biochemistry 38:4303-4312(1999) · UniProtKB (1) |
| Structure-based design and synthesis of lipophilic 2,4-diamino-6-substituted quinazolines and their evaluation as inhibitors of dihydrofolate reductases and potential antitumor agents. Gangjee A., Vidwans A.P., Vasudevan A., Queener S.F., Kisliuk R.L., Cody V., Li R., Galitsky N., Luft J.R., Pangborn W.
J. Med. Chem. 41:3426-3434(1998) · UniProtKB (1) |
| Comparison of ternary crystal complexes of F31 variants of human dihydrofolate reductase with NADPH and a classical antitumor furopyrimidine. Cody V., Galitsky N., Luft J.R., Pangborn W., Blakley R.L., Gangjee A.
Anticancer Drug Des. 13:307-315(1998) · Mapped (1) |
| Comparison of two independent crystal structures of human dihydrofolate reductase ternary complexes reduced with nicotinamide adenine dinucleotide phosphate and the very tight-binding inhibitor PT523. Cody V., Galitsky N., Luft J.R., Pangborn W., Blakley R.L., Gangjee A.
Biochemistry 36:13897-13903(1997) · UniProtKB (1) |
| Structural aspects of inotropic bipyridine binding. Crystal structure determination to 1.9 A of the human serum transthyretin-milrinone complex. Wojtczak A., Luft J.R., Cody V.
J. Biol. Chem. 268:6202-6206(1993) · Mapped (1) |
| Methotrexate-resistant variants of human dihydrofolate reductase with substitutions of leucine 22. Kinetics, crystallography, and potential as selectable markers. Lewis W.S., Cody V., Galitsky N., Luft J.R., Pangborn W., Chunduru S.K., Spencer H.T., Appleman J.R., Blakley R.L.
J. Biol. Chem. 270:5057-5064(1995) · UniProtKB (1) |
| Crystal structure determination at 2.3-A resolution of human transthyretin-3',5'-dibromo-2',4,4',6-tetrahydroxyaurone complex. Ciszak E., Cody V., Luft J.R.
Proc. Natl. Acad. Sci. U.S.A. 89:6644-6648(1992) · Mapped (1) |
