1 - 25 of 40 results for author:"Leppla S.H." in Literature citations
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| Anthrax lethal factor cleaves mouse nlrp1b in both toxin-sensitive and toxin-resistant macrophages. Hellmich K.A., Levinsohn J.L., Fattah R., Newman Z.L., Maier N., Sastalla I., Liu S., Leppla S.H., Moayeri M. PLoS ONE 7:e49741-e49741(2012) · Mapped (9) |
| Broad expression analysis of human ANTXR1/TEM8 transcripts reveals differential expression and novel splizce variants. Vargas M., Karamsetty R., Leppla S.H., Chaudry G.J. |
| Rapid induction of inflammatory lipid mediators by the inflammasome in vivo. von Moltke J., Trinidad N.J., Moayeri M., Kintzer A.F., Wang S.B., van Rooijen N., Brown C.R., Krantz B.A., Leppla S.H., Gronert K. et al. Nature 490:107-111(2012) · Mapped (21) |
| Diphthamide modification on eukaryotic elongation factor 2 is needed to assure fidelity of mRNA translation and mouse development. Liu S., Bachran C., Gupta P., Miller-Randolph S., Wang H., Crown D., Zhang Y., Wein A.N., Singh R., Fattah R. et al. Proc. Natl. Acad. Sci. U.S.A. 109:13817-13822(2012) · Mapped (22) |
| Capillary morphogenesis protein-2 is required for mouse parturition by maintaining uterine collagen homeostasis. Peters D.E., Zhang Y., Molinolo A.A., Miller-Randolph S., Szabo R., Bugge T.H., Leppla S.H., Liu S. Biochem. Biophys. Res. Commun. 422:393-397(2012) · Mapped (2) |
| Mutation in the platelet-derived growth factor receptor alpha inhibits adeno-associated virus type 5 transduction. Pilz I.H., Di Pasquale G., Rzadzinska A., Leppla S.H., Chiorini J.A. Virology 428:58-63(2012) · UniProtKB (1) |
| Anthrax lethal factor cleavage of Nlrp1 is required for activation of the inflammasome. Levinsohn J.L., Newman Z.L., Hellmich K.A., Fattah R., Getz M.A., Liu S., Sastalla I., Leppla S.H., Moayeri M. PLoS Pathog. 8:e1002638-e1002638(2012) · Mapped (6) |
| Antidotes to anthrax lethal factor intoxication. Part 3: Evaluation of core structures and further modifications to the C2-side chain. Jiao G.S., Kim S., Moayeri M., Crown D., Thai A., Cregar-Hernandez L., McKasson L., Sankaran B., Lehrer A., Wong T. et al. Bioorg. Med. Chem. Lett. 22:2242-2246(2012) · Mapped (1) |
| Anthrax edema toxin impairs clearance in mice. Sastalla I., Tang S., Crown D., Liu S., Eckhaus M.A., Hewlett I.K., Leppla S.H., Moayeri M. Infect. Immun. 80:529-538(2012) · Mapped (3) |
| Inflammasome sensor Nlrp1b-dependent resistance to anthrax is mediated by caspase-1, IL-1 signaling and neutrophil recruitment. Moayeri M., Crown D., Newman Z.L., Okugawa S., Eckhaus M., Cataisson C., Liu S., Sastalla I., Leppla S.H. PLoS Pathog. 6:e1001222-e1001222(2010) · Mapped (17) |
| MyD88-dependent signaling protects against anthrax lethal toxin-induced impairment of intestinal barrier function. Okugawa S., Moayeri M., Eckhaus M.A., Crown D., Miller-Randolph S., Liu S., Akira S., Leppla S.H. Infect. Immun. 79:118-124(2011) · Mapped (9) |
| Anthrax lethal toxin activates the inflammasome in sensitive rat macrophages. Newman Z.L., Crown D., Leppla S.H., Moayeri M. Biochem. Biophys. Res. Commun. 398:785-789(2010) · Mapped (3) |
| Susceptibility to anthrax lethal toxin-induced rat death is controlled by a single chromosome 10 locus that includes rNlrp1. Newman Z.L., Printz M.P., Liu S., Crown D., Breen L., Miller-Randolph S., Flodman P., Leppla S.H., Moayeri M. PLoS Pathog. 6:e1000906-e1000906(2010) · UniProtKB (5) · Mapped (1) |
| Selective abrogation of the uPA-uPAR interaction in vivo reveals a novel role in suppression of fibrin-associated inflammation. Connolly B.M., Choi E.Y., Gardsvoll H., Bey A.L., Currie B.M., Chavakis T., Liu S., Molinolo A., Ploug M., Leppla S.H. et al. Blood 116:1593-1603(2010) · Mapped (8) |
| Capillary morphogenesis protein-2 is the major receptor mediating lethality of anthrax toxin in vivo. Liu S., Crown D., Miller-Randolph S., Moayeri M., Wang H., Hu H., Morley T., Leppla S.H. Proc. Natl. Acad. Sci. U.S.A. 106:12424-12429(2009) · Mapped (3) |
| The heart is an early target of anthrax lethal toxin in mice: a protective role for neuronal nitric oxide synthase (nNOS). Moayeri M., Crown D., Dorward D.W., Gardner D., Ward J.M., Li Y., Cui X., Eichacker P., Leppla S.H. PLoS Pathog. 5:e1000456-e1000456(2009) · Mapped (2) |
| Heat shock inhibits caspase-1 activity while also preventing its inflammasome-mediated activation by anthrax lethal toxin. Levin T.C., Wickliffe K.E., Leppla S.H., Moayeri M. Cell. Microbiol. 10:2434-2446(2008) · Mapped (1) |
| Dph3, a small protein required for diphthamide biosynthesis, is essential in mouse development. Liu S., Wiggins J.F., Sreenath T., Kulkarni A.B., Ward J.M., Leppla S.H. Mol. Cell. Biol. 26:3835-3841(2006) · UniProtKB (1) · Mapped (4) |
| The LDL receptor-related protein LRP6 mediates internalization and lethality of anthrax toxin. Wei W., Lu Q., Chaudry G.J., Leppla S.H., Cohen S.N. Cell 124:1141-1154(2006) · Mapped (10) |
| Receptor palmitoylation and ubiquitination regulate anthrax toxin endocytosis. Abrami L., Leppla S.H., van der Goot F.G. J. Cell Biol. 172:309-320(2006) · Mapped (9) |
| Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2. Liu S., Milne G.T., Kuremsky J.G., Fink G.R., Leppla S.H. Mol. Cell. Biol. 24:9487-9497(2004) · UniProtKB (7) · Mapped (6) |
| Membrane insertion of anthrax protective antigen and cytoplasmic delivery of lethal factor occur at different stages of the endocytic pathway. Abrami L., Lindsay M., Parton R.G., Leppla S.H., van der Goot F.G. J. Cell Biol. 166:645-651(2004) · UniProtKB (1) |
| Mouse susceptibility to anthrax lethal toxin is influenced by genetic factors in addition to those controlling macrophage sensitivity. Moayeri M., Martinez N.W., Wiggins J., Young H.A., Leppla S.H. Infect. Immun. 72:4439-4447(2004) · Mapped (13) |
| Crystal structure of a complex between anthrax toxin and its host cell receptor. Santelli E., Bankston L.A., Leppla S.H., Liddington R.C. |
| The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor. Turk B.E., Wong T.Y., Schwarzenbacher R., Jarrell E.T., Leppla S.H., Collier R.J., Liddington R.C., Cantley L.C. Nat. Struct. Mol. Biol. 11:60-66(2004) · UniProtKB (1) |