17 results for author:"Lawrence N.J." in Literature citations
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| Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2). Pireddu R., Forinash K.D., Sun N.N., Martin M.P., Sung S.S., Alexander B., Zhu J.Y., Guida W.C., Schonbrunn E., Sebti S.M. et al. Medchemcomm 3:699-709(2012) · Mapped (1) |
| Regulation of interlocking gene regulatory network subcircuits by a small molecule inhibitor of retinoblastoma protein (RB) phosphorylation: cancer cell expression of HLA-DR. Pillai S., Szekeres K., Lawrence N.J., Chellappan S.P., Blanck G. Gene 512:403-407(2013) · Mapped (18) |
| RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer. Patel R.A., Forinash K.D., Pireddu R., Sun Y., Sun N., Martin M.P., Schonbrunn E., Lawrence N.J., Sebti S.M. Cancer Res. 72:5025-5034(2012) · Mapped (1) |
| Development of o-chlorophenyl substituted pyrimidines as exceptionally potent aurora kinase inhibitors. Lawrence H.R., Martin M.P., Luo Y., Pireddu R., Yang H., Gevariya H., Ozcan S., Zhu J.Y., Kendig R., Rodriguez M. et al. J. Med. Chem. 55:7392-7416(2012) · Mapped (1) |
| Ack1-mediated androgen receptor phosphorylation modulates radiation resistance in castration-resistant prostate cancer. Mahajan K., Coppola D., Rawal B., Chen Y.A., Lawrence H.R., Engelman R.W., Lawrence N.J., Mahajan N.P. J. Biol. Chem. 287:22112-22122(2012) · Mapped (6) |
| Ack1 tyrosine kinase activation correlates with pancreatic cancer progression. Mahajan K., Coppola D., Chen Y.A., Zhu W., Lawrence H.R., Lawrence N.J., Mahajan N.P. Am. J. Pathol. 180:1386-1393(2012) · Mapped (12) |
| Fragment-based and structure-guided discovery and optimization of Rho kinase inhibitors. Li R., Martin M.P., Liu Y., Wang B., Patel R.A., Zhu J.Y., Sun N., Pireddu R., Lawrence N.J., Li J. et al. J. Med. Chem. 55:2474-2478(2012) · Mapped (1) |
| A novel mechanism by which small molecule inhibitors induce the DFG flip in Aurora A. Martin M.P., Zhu J.Y., Lawrence H.R., Pireddu R., Luo Y., Alam R., Ozcan S., Sebti S.M., Lawrence N.J., Schonbrunn E. ACS Chem. Biol. 7:698-706(2012) · Mapped (2) |
| Critical role of IRF-8 in negative regulation of TLR3 expression by Src homology 2 domain-containing protein tyrosine phosphatase-2 activity in human myeloid dendritic cells. Fragale A., Stellacci E., Ilari R., Remoli A.L., Lanciotti A., Perrotti E., Shytaj I., Orsatti R., Lawrence H.R., Lawrence N.J. et al. J. Immunol. 186:1951-1962(2011) · Mapped (7) |
| Effect of Ack1 tyrosine kinase inhibitor on ligand-independent androgen receptor activity. Mahajan K., Challa S., Coppola D., Lawrence H., Luo Y., Gevariya H., Zhu W., Chen Y.A., Lawrence N.J., Mahajan N.P. Prostate 70:1274-1285(2010) · UniProtKB (2) |
| Cell shape changes indicate a role for extrinsic tensile forces in Drosophila germ-band extension. Butler L.C., Blanchard G.B., Kabla A.J., Lawrence N.J., Welchman D.P., Mahadevan L., Adams R.J., Sanson B. Nat. Cell Biol. 11:859-864(2009) · Mapped (8) |
| The pro-apoptotic K-Ras 4A proto-oncoprotein does not affect tumorigenesis in the ApcMin/+ mouse small intestine. Patek C.E., Arends M.J., Rose L., Luo F., Walker M., Devenney P.S., Berry R.L., Lawrence N.J., Ridgway R.A., Sansom O.J. et al. BMC Gastroenterol 8:24-24(2008) · Mapped (18) |
| A neurological phenotype in mice with DNA repair gene Ercc1 deficiency. Lawrence N.J., Sacco J.J., Brownstein D.G., Gillingwater T.H., Melton D.W. DNA Repair (Amst.) 7:281-291(2008) · Mapped (2) |
| Effects on kidney disease, fertility and development in mice inheriting a protein-truncating Denys-Drash syndrome allele (Wt1tmT396). Patek C.E., Brownstein D.G., Fleming S., Wroe C., Rose L., Webb A., Berry R.L., Devenney P.S., Walker M., Maddocks O.D. et al. Transgenic Res. 17:459-475(2008) · Mapped (8) |
| Deletion of genes implicated in protecting the integrity of male germ cells has differential effects on the incidence of DNA breaks and germ cell loss. Paul C., Povey J.E., Lawrence N.J., Selfridge J., Melton D.W., Saunders P.T. PLoS ONE 2:e989-e989(2007) · Mapped (24) |
| Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity. Siddiquee K., Zhang S., Guida W.C., Blaskovich M.A., Greedy B., Lawrence H.R., Yip M.L., Jove R., McLaughlin M.M., Lawrence N.J. et al. Proc. Natl. Acad. Sci. U.S.A. 104:7391-7396(2007) · Mapped (14) |
| Mice with skin-specific DNA repair gene (Ercc1) inactivation are hypersensitive to ultraviolet irradiation-induced skin cancer and show more rapid actinic progression. Doig J., Anderson C., Lawrence N.J., Selfridge J., Brownstein D.G., Melton D.W. Oncogene 25:6229-6238(2006) · Mapped (8) |