| Genetic variations in sex steroid-related genes as predictors of serum estrogen levels in men. Eriksson A.L., Lorentzon M., Vandenput L., Labrie F., Lindersson M., Syvanen A.C., Orwoll E.S., Cummings S.R., Zmuda J.M., Ljunggren O. et al.
J. Clin. Endocrinol. Metab. 94:1033-1041(2009) · Mapped (9) |
| Crystal structures of human Delta4-3-ketosteroid 5beta-reductase (AKR1D1) reveal the presence of an alternative binding site responsible for substrate inhibition. Faucher F., Cantin L., Luu-The V., Labrie F., Breton R.
Biochemistry 47:13537-13546(2008) · Mapped (7) |
| Expression of 17beta-hydroxysteroid dehydrogenase type 2 and type 5 in breast cancer and adjacent non-malignant tissue: a correlation to clinicopathological parameters. Han B., Li S., Song D., Poisson-Pare D., Liu G., Luu-The V., Ouellet J., Li S., Labrie F., Pelletier G.
J. Steroid Biochem. Mol. Biol. 112:194-200(2008) · Mapped (5) |
| The crystal structure of human Delta4-3-ketosteroid 5beta-reductase defines the functional role of the residues of the catalytic tetrad in the steroid double bond reduction mechanism. Faucher F., Cantin L., Luu-The V., Labrie F., Breton R.
Biochemistry 47:8261-8270(2008) · Mapped (1) |
| Identification of novel glucocorticoid receptor-regulated genes involved in epidermal homeostasis and hair follicle differentiation. Donet E., Bayo P., Calvo E., Labrie F., Perez P.
J. Steroid Biochem. Mol. Biol. 108:8-16(2008) · Mapped (6) |
| Structural characterization of the human androgen receptor ligand-binding domain complexed with EM5744, a rationally designed steroidal ligand bearing a bulky chain directed toward helix 12. Cantin L., Faucher F., Couture J.-F., de Jesus-Tran K.P., Legrand P., Ciobanu L.C., Frechette Y., Labrecque R., Singh S.M., Labrie F. et al.
J. Biol. Chem. 282:30910-30919(2007) · UniProtKB (1) |
| The uridine diphosphate glucuronosyltransferase 2B15 D85Y and 2B17 deletion polymorphisms predict the glucuronidation pattern of androgens and fat mass in men. Swanson C., Mellstrom D., Lorentzon M., Vandenput L., Jakobsson J., Rane A., Karlsson M., Ljunggren O., Smith U., Eriksson A.L. et al.
J. Clin. Endocrinol. Metab. 92:4878-4882(2007) · Mapped (4) |
| Sex steroid levels and cortical bone size in young men are associated with a uridine diphosphate glucuronosyltransferase 2B7 polymorphism (H268Y). Swanson C., Lorentzon M., Vandenput L., Labrie F., Rane A., Jakobsson J., Chouinard S., Belanger A., Ohlsson C.
J. Clin. Endocrinol. Metab. 92:3697-3704(2007) · Mapped (4) |
| Mouse 17alpha-hydroxysteroid dehydrogenase (AKR1C21) binds steroids differently from other aldo-keto reductases: identification and characterization of amino acid residues critical for substrate binding. Faucher F., Cantin L., Pereira de Jesus-Tran K., Lemieux M., Luu-The V., Labrie F., Breton R.
J. Mol. Biol. 369:525-540(2007) · UniProtKB (1) · Mapped (1) |
| Oestrogenic regulation of pro-opiomelanocortin, neuropeptide Y and corticotrophin-releasing hormone mRNAs in mouse hypothalamus. Pelletier G., Li S., Luu-The V., Labrie F.
J. Neuroendocrinol. 19:426-431(2007) · Mapped (3) |
| Evaluation of AIbZIP and Cdc47 as markers for human prostatic diseases. Levesque M.H., El-Alfy M., Berger L., Labrie F., Labrie C.
Urology 69:196-201(2007) · UniProtKB (1) |
| Expression of sulfotransferase 1E1 in human prostate as studied by in situ hybridization and immunocytochemistry. Takase Y., Luu-The V., Poisson-Pare D., Labrie F., Pelletier G.
Prostate 67:405-409(2007) · Mapped (2) |
| Structure-based inhibitor design for an enzyme that binds different steroids: a potent inhibitor for human type 5 17beta-hydroxysteroid dehydrogenase. Qiu W., Zhou M., Mazumdar M., Azzi A., Ghanmi D., Luu-The V., Labrie F., Lin S.X.
J. Biol. Chem. 282:8368-8379(2007) · Mapped (3) |
| Crystal structures of mouse 17alpha-hydroxysteroid dehydrogenase (apoenzyme and enzyme-NADP(H) binary complex): identification of molecular determinants responsible for the unique 17alpha-reductive activity of this enzyme. Faucher F., Pereira de Jesus-Tran K., Cantin L., Luu-The V., Labrie F., Breton R.
J. Mol. Biol. 364:747-763(2006) · UniProtKB (1) · Mapped (1) |
| Expression of aromatase and 17beta-hydroxysteroid dehydrogenase types 1, 7 and 12 in breast cancer. An immunocytochemical study. Song D., Liu G., Luu-The V., Zhao D., Wang L., Zhang H., Xueling G., Li S., Desy L., Labrie F. et al.
J. Steroid Biochem. Mol. Biol. 101:136-144(2006) · Mapped (10) |
| SHBG gene promoter polymorphisms in men are associated with serum sex hormone-binding globulin, androgen and androgen metabolite levels, and hip bone mineral density. Eriksson A.L., Lorentzon M., Mellstrom D., Vandenput L., Swanson C., Andersson N., Hammond G.L., Jakobsson J., Rane A., Orwoll E.S. et al.
J. Clin. Endocrinol. Metab. 91:5029-5037(2006) · Mapped (8) |
| Comparison of crystal structures of human androgen receptor ligand-binding domain complexed with various agonists reveals molecular determinants responsible for binding affinity. Pereira de Jesus-Tran K., Cote P.-L., Cantin L., Blanchet J., Labrie F., Breton R.
Protein Sci. 15:987-999(2006) · UniProtKB (1) · Mapped (7) |
| Isolation and characterization of a cDNA encoding mouse 3alpha-hydroxysteroid dehydrogenase: an androgen-inactivating enzyme selectively expressed in female tissues. Bellemare V., Labrie F., Luu-The V.
J. Steroid Biochem. Mol. Biol. 98:18-24(2006) · UniProtKB (1) |
| Characterization of type 12 17beta-hydroxysteroid dehydrogenase, an isoform of type 3 17beta-hydroxysteroid dehydrogenase responsible for estradiol formation in women. Luu-The V., Tremblay P., Labrie F.
Mol. Endocrinol. 20:437-443(2006) · UniProtKB (1) · Mapped (3) |
| Comparison of crystal structures of human type 3 3alpha-hydroxysteroid dehydrogenase reveals an "induced-fit" mechanism and a conserved basic motif involved in the binding of androgen. Couture J.F., de Jesus-Tran K.P., Roy A.M., Cantin L., Cote P.L., Legrand P., Luu-The V., Labrie F., Breton R.
Protein Sci. 14:1485-1497(2005) · Mapped (1) |
| Localization of type 8 17beta-hydroxysteroid dehydrogenase mRNA in mouse tissues as studied by in situ hybridization. Pelletier G., Luu-The V., Li S., Labrie F.
J. Histochem. Cytochem. 53:1257-1271(2005) · UniProtKB (1) |
| Estradiol is required for a proper immune response to bacterial and viral pathogens in the female brain. Soucy G., Boivin G., Labrie F., Rivest S.
J. Immunol. 174:6391-6398(2005) · Mapped (4) |
| Quantitative appreciation of steroidogenic gene expression in mouse tissues: new roles for type 2 5alpha-reductase, 20alpha-hydroxysteroid dehydrogenase and estrogen sulfotransferase. Luu-The V., Pelletier G., Labrie F.
J. Steroid Biochem. Mol. Biol. 93:269-276(2005) · Mapped (3) |
| Specificity and regioselectivity of the conjugation of estradiol, estrone, and their catecholestrogen and methoxyestrogen metabolites by human uridine diphospho-glucuronosyltransferases expressed in endometrium. Lepine J., Bernard O., Plante M., Tetu B., Pelletier G., Labrie F., Belanger A., Guillemette C.
J. Clin. Endocrinol. Metab. 89:5222-5232(2004) · Mapped (10) |
| Structure of primate and rodent orthologs of the prostate cancer susceptibility gene ELAC2. Dumont M., Frank D., Moisan A.-M., Tranchant M., Soucy P., Breton R., Labrie F., Tavtigian S.V., Simard J.
Biochim. Biophys. Acta 1679:230-247(2004) · UniProtKB (3) |
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