| The extracellular signal-regulated kinase 3 (mitogen-activated protein kinase 6 [MAPK6])-MAPK-activated protein kinase 5 signaling complex regulates septin function and dendrite morphology. Brand F., Schumacher S., Kant S., Menon M.B., Simon R., Turgeon B., Britsch S., Meloche S., Gaestel M., Kotlyarov A.
Mol. Cell. Biol. 32:2467-2478(2012) · Mapped (14) |
| Distinct functions of the mitogen-activated protein kinase-activated protein (MAPKAP) kinases MK2 and MK3: MK2 mediates lipopolysaccharide-induced signal transducers and activators of transcription 3 (STAT3) activation by preventing negative regulatory effects of MK3. Ehlting C., Ronkina N., Bohmer O., Albrecht U., Bode K.A., Lang K.S., Kotlyarov A., Radzioch D., Gaestel M., Haussinger D. et al.
J. Biol. Chem. 286:24113-24124(2011) · Mapped (10) |
| p38 MAP kinase and MAPKAP kinases MK2/3 cooperatively phosphorylate epithelial keratins. Menon M.B., Schwermann J., Singh A.K., Franz-Wachtel M., Pabst O., Seidler U., Omary M.B., Kotlyarov A., Gaestel M.
J. Biol. Chem. 285:33242-33251(2010) · UniProtKB (5) · Mapped (8) |
| MAPKAP kinases MK2 and MK3 in inflammation: complex regulation of TNF biosynthesis via expression and phosphorylation of tristetraprolin. Ronkina N., Menon M.B., Schwermann J., Tiedje C., Hitti E., Kotlyarov A., Gaestel M.
Biochem. Pharmacol. 80:1915-1920(2010) · UniProtKB (1) |
| MAPKAP kinase MK2 maintains self-renewal capacity of haematopoietic stem cells. Schwermann J., Rathinam C., Schubert M., Schumacher S., Noyan F., Koseki H., Kotlyarov A., Klein C., Gaestel M.
EMBO J. 28:1392-1406(2009) · Mapped (3) |
| MAP-kinase-activated protein kinase 2 expression and activity is induced after neuronal depolarization. Thomas T., Hitti E., Kotlyarov A., Potschka H., Gaestel M.
Eur. J. Neurosci. 28:642-654(2008) · Mapped (3) |
| MK2 and MK3--a pair of isoenzymes? Ronkina N., Kotlyarov A., Gaestel M.
Front. Biosci. 13:5511-5521(2008) · UniProtKB (2) |
| The mitogen-activated protein kinase (MAPK)-activated protein kinases MK2 and MK3 cooperate in stimulation of tumor necrosis factor biosynthesis and stabilization of p38 MAPK. Ronkina N., Kotlyarov A., Dittrich-Breiholz O., Kracht M., Hitti E., Milarski K., Askew R., Marusic S., Lin L.L., Gaestel M. et al.
Mol. Cell. Biol. 27:170-181(2007) · UniProtKB (2) · Mapped (13) |
| Characterization of the atypical MAPK ERK4 and its activation of the MAPK-activated protein kinase MK5. Kant S., Schumacher S., Singh M.K., Kispert A., Kotlyarov A., Gaestel M.
J. Biol. Chem. 281:35511-35519(2006) · UniProtKB (3) · Mapped (14) |
| Analysis of properties of small heat shock protein Hsp25 in MAPK-activated protein kinase 2 (MK2)-deficient cells: MK2-dependent insolubilization of Hsp25 oligomers correlates with susceptibility to stress. Vertii A., Hakim C., Kotlyarov A., Gaestel M.
J. Biol. Chem. 281:26966-26975(2006) · Mapped (9) |
| Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor mRNA stability and translation mainly by altering tristetraprolin expression, stability, and binding to adenine/uridine-rich element. Hitti E., Iakovleva T., Brook M., Deppenmeier S., Gruber A.D., Radzioch D., Clark A.R., Blackshear P.J., Kotlyarov A., Gaestel M.
Mol. Cell. Biol. 26:2399-2407(2006) · Mapped (11) |
| Gene deletion of MK2 inhibits TNF-alpha and IL-6 and protects against cerulein-induced pancreatitis. Tietz A.B., Malo A., Diebold J., Kotlyarov A., Herbst A., Kolligs F.T., Brandt-Nedelev B., Halangk W., Gaestel M., Goke B. et al.
Am. J. Physiol. Gastrointest. Liver Physiol. 290:G1298-306(2006) · Mapped (8) |
| Scaffolding by ERK3 regulates MK5 in development. Schumacher S., Laass K., Kant S., Shi Y., Visel A., Gruber A.D., Kotlyarov A., Gaestel M.
EMBO J. 23:4770-4779(2004) · UniProtKB (2) · Mapped (8) |
| A requirement of MAPKAPK2 in the uropod localization of PTEN during FMLP-induced neutrophil chemotaxis. Wu Y., Hannigan M.O., Kotlyarov A., Gaestel M., Wu D., Huang C.K.
Biochem. Biophys. Res. Commun. 316:666-672(2004) · Mapped (4) |
| Elimination of protein kinase MK5/PRAK activity by targeted homologous recombination. Shi Y., Kotlyarov A., Laabeta K., Gruber A.D., Butt E., Marcus K., Meyer H.E., Friedrich A., Volk H.D., Gaestel M.
Mol. Cell. Biol. 23:7732-7741(2003) · UniProtKB (1) · Mapped (6) |
| Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease. Kontoyiannis D., Boulougouris G., Manoloukos M., Armaka M., Apostolaki M., Pizarro T., Kotlyarov A., Forster I., Flavell R., Gaestel M. et al.
J. Exp. Med. 196:1563-1574(2002) · Mapped (59) |
| Is MK2 (mitogen-activated protein kinase-activated protein kinase 2) the key for understanding post-transcriptional regulation of gene expression? Kotlyarov A., Gaestel M.
Biochem. Soc. Trans. 30:959-963(2002) · Mapped (5) |
| Distinct cellular functions of MK2. Kotlyarov A., Yannoni Y., Fritz S., Laass K., Telliez J.B., Pitman D., Lin L.L., Gaestel M.
Mol. Cell. Biol. 22:4827-4835(2002) · UniProtKB (1) · Mapped (7) |
| Mitogen-activated protein kinase-activated protein kinase 2-deficient mice show increased susceptibility to Listeria monocytogenes infection. Lehner M.D., Schwoebel F., Kotlyarov A., Leist M., Gaestel M., Hartung T.
J. Immunol. 168:4667-4673(2002) · Mapped (3) |
| MK2 targets AU-rich elements and regulates biosynthesis of tumor necrosis factor and interleukin-6 independently at different post-transcriptional levels. Neininger A., Kontoyiannis D., Kotlyarov A., Winzen R., Eckert R., Volk H.D., Holtmann H., Kollias G., Gaestel M.
J. Biol. Chem. 277:3065-3068(2002) · Mapped (3) |
| Abnormal migration phenotype of mitogen-activated protein kinase-activated protein kinase 2-/- neutrophils in Zigmond chambers containing formyl-methionyl-leucyl-phenylalanine gradients. Hannigan M.O., Zhan L., Ai Y., Kotlyarov A., Gaestel M., Huang C.K.
J. Immunol. 167:3953-3961(2001) · Mapped (3) |
| Interleukin-10 targets p38 MAPK to modulate ARE-dependent TNF mRNA translation and limit intestinal pathology. Kontoyiannis D., Kotlyarov A., Carballo E., Alexopoulou L., Blackshear P.J., Gaestel M., Davis R., Flavell R., Kollias G.
EMBO J. 20:3760-3770(2001) · Mapped (27) |
| MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis. Kotlyarov A., Neininger A., Schubert C., Eckert R., Birchmeier C., Volk H.D., Gaestel M.
Nat. Cell Biol. 1:94-97(1999) · UniProtKB (1) · Mapped (2) |
| Regulation of Hsp27 oligomerization, chaperone function, and protective activity against oxidative stress/tumor necrosis factor alpha by phosphorylation. Rogalla T., Ehrnsperger M., Preville X., Kotlyarov A., Lutsch G., Ducasse C., Paul C., Wieske M., Arrigo A.P., Buchner J. et al.
J. Biol. Chem. 274:18947-18956(1999) · UniProtKB (3) |
| Leptomycin B-sensitive nuclear export of MAPKAP kinase 2 is regulated by phosphorylation. Engel K., Kotlyarov A., Gaestel M.
EMBO J. 17:3363-3371(1998) · UniProtKB (1) · Mapped (2) |
