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A noncoding RNA regulates the neurogenin1 gene locus during mouse neocortical development.

Onoguchi M., Hirabayashi Y., Koseki H., Gotoh Y.

Proc. Natl. Acad. Sci. U.S.A. 109:16939-16944(2012) · Mapped (2)

Histone H2A mono-ubiquitination is a crucial step to mediate PRC1-dependent repression of developmental genes to maintain ES cell identity.

Endoh M., Endo T.A., Endoh T., Isono K., Sharif J., Ohara O., Toyoda T., Ito T., Eskeland R., Bickmore W.A. et al.

PLoS Genet. 8:e1002774-e1002774(2012) · Mapped (12)

SF3B1 haploinsufficiency leads to formation of ring sideroblasts in myelodysplastic syndromes.

Visconte V., Rogers H.J., Singh J., Barnard J., Bupathi M., Traina F., McMahon J., Makishima H., Szpurka H., Jankowska A. et al.

Blood 120:3173-3186(2012) · Mapped (17)

Ezh2 augments leukemogenicity by reinforcing differentiation blockage in acute myeloid leukemia.

Tanaka S., Miyagi S., Sashida G., Chiba T., Yuan J., Mochizuki-Kashio M., Suzuki Y., Sugano S., Nakaseko C., Yokote K. et al.

Blood 120:1107-1117(2012) · Mapped (19)

Ring1a/b polycomb proteins regulate the mesenchymal stem cell niche in continuously growing incisors.

Lapthanasupkul P., Feng J., Mantesso A., Takada-Horisawa Y., Vidal M., Koseki H., Wang L., An Z., Miletich I., Sharpe P.T.

Dev. Biol. 367:140-153(2012) · Mapped (2)

Type II membrane protein CD69 regulates the formation of resting T-helper memory.

Shinoda K., Tokoyoda K., Hanazawa A., Hayashizaki K., Zehentmeier S., Hosokawa H., Iwamura C., Koseki H., Tumes D.J., Radbruch A. et al.

Proc. Natl. Acad. Sci. U.S.A. 109:7409-7414(2012) · Mapped (2)

Lethal myelofibrosis induced by Bmi1-deficient hematopoietic cells unveils a tumor suppressor function of the polycomb group genes.

Oguro H., Yuan J., Tanaka S., Miyagi S., Mochizuki-Kashio M., Ichikawa H., Yamazaki S., Koseki H., Nakauchi H., Iwama A.

J. Exp. Med. 209:445-454(2012) · Mapped (10)

Development and function of invariant natural killer T cells producing T(h)2- and T(h)17-cytokines.

Watarai H., Sekine-Kondo E., Shigeura T., Motomura Y., Yasuda T., Satoh R., Yoshida H., Kubo M., Kawamoto H., Koseki H. et al.

PLoS Biol. 10:e1001255-e1001255(2012) · Mapped (16)

Membrane-bound human SCF/KL promotes in vivo human hematopoietic engraftment and myeloid differentiation.

Takagi S., Saito Y., Hijikata A., Tanaka S., Watanabe T., Hasegawa T., Mochizuki S., Kunisawa J., Kiyono H., Koseki H. et al.

Blood 119:2768-2777(2012) · Mapped (6)

RYBP represses endogenous retroviruses and preimplantation- and germ line-specific genes in mouse embryonic stem cells.

Hisada K., Sanchez C., Endo T.A., Endoh M., Roman-Trufero M., Sharif J., Koseki H., Vidal M.

Mol. Cell. Biol. 32:1139-1149(2012) · Mapped (28)

CBX8, a polycomb group protein, is essential for MLL-AF9-induced leukemogenesis.

Tan J., Jones M., Koseki H., Nakayama M., Muntean A.G., Maillard I., Hess J.L.

Cancer Cell 20:563-575(2011) · Mapped (2)

S phase-dependent interaction with DNMT1 dictates the role of UHRF1 but not UHRF2 in DNA methylation maintenance.

Zhang J., Gao Q., Li P., Liu X., Jia Y., Wu W., Li J., Dong S., Koseki H., Wong J.

Cell Res. 21:1723-1739(2011) · Mapped (8)

Dependency on the polycomb gene Ezh2 distinguishes fetal from adult hematopoietic stem cells.

Mochizuki-Kashio M., Mishima Y., Miyagi S., Negishi M., Saraya A., Konuma T., Shinga J., Koseki H., Iwama A.

Blood 118:6553-6561(2011) · Mapped (16)

HP1gamma links histone methylation marks to meiotic synapsis in mice.

Takada Y., Naruse C., Costa Y., Shirakawa T., Tachibana M., Sharif J., Kezuka-Shiotani F., Kakiuchi D., Masumoto H., Shinkai Y. et al.

Development 138:4207-4217(2011) · Mapped (14)

The Hbo1-Brd1/Brpf2 complex is responsible for global acetylation of H3K14 and required for fetal liver erythropoiesis.

Mishima Y., Miyagi S., Saraya A., Negishi M., Endoh M., Endo T.A., Toyoda T., Shinga J., Katsumoto T., Chiba T. et al.

Blood 118:2443-2453(2011) · Mapped (24)

Gab2, via PI-3K, regulates ARF1 in FcepsilonRI-mediated granule translocation and mast cell degranulation.

Nishida K., Yamasaki S., Hasegawa A., Iwamatsu A., Koseki H., Hirano T.

J. Immunol. 187:932-941(2011) · Mapped (11)

The zinc transporter SLC39A14/ZIP14 controls G-protein coupled receptor-mediated signaling required for systemic growth.

Hojyo S., Fukada T., Shimoda S., Ohashi W., Bin B.H., Koseki H., Hirano T.

PLoS ONE 6:e18059-e18059(2011) · Mapped (15)

Polycomblike 2 facilitates the recruitment of PRC2 Polycomb group complexes to the inactive X chromosome and to target loci in embryonic stem cells.

Casanova M., Preissner T., Cerase A., Poot R., Yamada D., Li X., Appanah R., Bezstarosti K., Demmers J., Koseki H. et al.

Development 138:1471-1482(2011) · UniProtKB (1) · Mapped (11)

Bmi1 regulates cell fate via tumor suppressor WWOX repression in small-cell lung cancer cells.

Kimura M., Takenobu H., Akita N., Nakazawa A., Ochiai H., Shimozato O., Fujimura Y., Koseki H., Yoshino I., Kimura H. et al.

Cancer Sci. 102:983-990(2011) · Mapped (3)

Irxl1 mutant mice show reduced tendon differentiation and no patterning defects in musculoskeletal system development.

Kimura W., Machii M., Xue X., Sultana N., Hikosaka K., Sharkar M.T., Uezato T., Matsuda M., Koseki H., Miura N.

Genesis 49:2-9(2011) · Mapped (34)

Mammalian polycomb-like Pcl2/Mtf2 is a novel regulatory component of PRC2 that can differentially modulate polycomb activity both at the Hox gene cluster and at Cdkn2a genes.

Li X., Isono K., Yamada D., Endo T.A., Endoh M., Shinga J., Mizutani-Koseki Y., Otte A.P., Casanova M., Kitamura H. et al.

Mol. Cell. Biol. 31:351-364(2011) · UniProtKB (1) · Mapped (41)

A novel zinc finger protein Zfp277 mediates transcriptional repression of the Ink4a/arf locus through polycomb repressive complex 1.

Negishi M., Saraya A., Mochizuki S., Helin K., Koseki H., Iwama A.

PLoS ONE 5:e12373-e12373(2010) · Mapped (13)

Selective ablation of basophils in mice reveals their nonredundant role in acquired immunity against ticks.

Wada T., Ishiwata K., Koseki H., Ishikura T., Ugajin T., Ohnuma N., Obata K., Ishikawa R., Yoshikawa S., Mukai K. et al.

J. Clin. Invest. 120:2867-2875(2010) · Mapped (18)

ESCs require PRC2 to direct the successful reprogramming of differentiated cells toward pluripotency.

Pereira C.F., Piccolo F.M., Tsubouchi T., Sauer S., Ryan N.K., Bruno L., Landeira D., Santos J., Banito A., Gil J. et al.

Cell Stem Cell 6:547-556(2010) · Mapped (17)

Polycomb group molecule PHC3 regulates polycomb complex composition and prognosis of osteosarcoma.

Iwata S., Takenobu H., Kageyama H., Koseki H., Ishii T., Nakazawa A., Tatezaki S., Nakagawara A., Kamijo T.

Cancer Sci. 101:1646-1652(2010) · Mapped (5)

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