| Nrf2 deficiency improves glucose tolerance in mice fed a high-fat diet. Zhang Y.K., Wu K.C., Liu J., Klaassen C.D.
Toxicol. Appl. Pharmacol. 264:305-314(2012) · Mapped (6) |
| Effect of graded Nrf2 activation on phase-I and -II drug metabolizing enzymes and transporters in mouse liver. Wu K.C., Cui J.Y., Klaassen C.D.
PLoS ONE 7:e39006-e39006(2012) · Mapped (6) |
| Nrf2 activation prevents cadmium-induced acute liver injury. Wu K.C., Liu J.J., Klaassen C.D.
Toxicol. Appl. Pharmacol. 263:14-20(2012) · Mapped (6) |
| Hormonal and chemical regulation of paraoxonases in mice. Cheng X., Klaassen C.D.
J. Pharmacol. Exp. Ther. 342:688-695(2012) · Mapped (5) |
| Role of Nrf2 in preventing ethanol-induced oxidative stress and lipid accumulation. Wu K.C., Liu J., Klaassen C.D.
Toxicol. Appl. Pharmacol. 262:321-329(2012) · Mapped (6) |
| Dysfunction of organic anion transporting polypeptide 1a1 alters intestinal bacteria and bile acid metabolism in mice. Zhang Y., Limaye P.B., Lehman-McKeeman L.D., Klaassen C.D.
PLoS ONE 7:e34522-e34522(2012) · Mapped (3) |
| Coordinated regulation of hepatic phase I and II drug-metabolizing genes and transporters using AhR-, CAR-, PXR-, PPARalpha-, and Nrf2-null mice. Aleksunes L.M., Klaassen C.D.
Drug Metab. Dispos. 40:1366-1379(2012) · Mapped (11) |
| Organic anion transporting polypeptide 1a1 null mice are sensitive to cholestatic liver injury. Zhang Y., Csanaky I.L., Cheng X., Lehman-McKeeman L.D., Klaassen C.D.
Toxicol. Sci. 127:451-462(2012) · Mapped (4) |
| RNA-Seq reveals different mRNA abundance of transporters and their alternative transcript isoforms during liver development. Cui J.Y., Gunewardena S.S., Yoo B., Liu J., Renaud H.J., Lu H., Zhong X.B., Klaassen C.D.
Toxicol. Sci. 127:592-608(2012) · Mapped (28) |
| Bile acids via FXR initiate the expression of major transporters involved in the enterohepatic circulation of bile acids in newborn mice. Cui J.Y., Aleksunes L.M., Tanaka Y., Fu Z.D., Guo Y., Guo G.L., Lu H., Zhong X.B., Klaassen C.D.
Am. J. Physiol. Gastrointest. Liver Physiol. 302:G979-96(2012) · Mapped (4) |
| Th2 skewing by activation of Nrf2 in CD4(+) T cells. Rockwell C.E., Zhang M., Fields P.E., Klaassen C.D.
J. Immunol. 188:1630-1637(2012) · Mapped (2) |
| Impaired generation of 12-hydroxylated bile acids links hepatic insulin signaling with dyslipidemia. Haeusler R.A., Pratt-Hyatt M., Welch C.L., Klaassen C.D., Accili D.
Cell Metab. 15:65-74(2012) · Mapped (21) |
| Glucose and insulin induction of bile acid synthesis: mechanisms and implication in diabetes and obesity. Li T., Francl J.M., Boehme S., Ochoa A., Zhang Y., Klaassen C.D., Erickson S.K., Chiang J.Y.
J. Biol. Chem. 287:1861-1873(2012) · Mapped (9) |
| Loss of organic anion transporting polypeptide 1a1 increases deoxycholic acid absorption in mice by increasing intestinal permeability. Zhang Y., Csanaky I.L., Lehman-McKeeman L.D., Klaassen C.D.
Toxicol. Sci. 124:251-260(2011) · Mapped (4) |
| CYP2D plays a major role in berberine metabolism in liver of mice and humans. Guo Y., Li F., Ma X., Cheng X., Zhou H., Klaassen C.D.
Xenobiotica 41:996-1005(2011) · Mapped (18) |
| Beneficial role of Nrf2 in regulating NADPH generation and consumption. Wu K.C., Cui J.Y., Klaassen C.D.
Toxicol. Sci. 123:590-600(2011) · Mapped (6) |
| Characterization of organic anion-transporting polypeptide (Oatp) 1a1 and 1a4 null mice reveals altered transport function and urinary metabolomic profiles. Gong L., Aranibar N., Han Y.H., Zhang Y., Lecureux L., Bhaskaran V., Khandelwal P., Klaassen C.D., Lehman-McKeeman L.D.
Toxicol. Sci. 122:587-597(2011) · Mapped (7) |
| ChIPing the cistrome of PXR in mouse liver. Cui J.Y., Gunewardena S.S., Rockwell C.E., Klaassen C.D.
Nucleic Acids Res. 38:7943-7963(2010) · Mapped (3) |
| Enhanced expression of Nrf2 in mice attenuates the fatty liver produced by a methionine- and choline-deficient diet. Zhang Y.K., Yeager R.L., Tanaka Y., Klaassen C.D.
Toxicol. Appl. Pharmacol. 245:326-334(2010) · Mapped (2) |
| Nuclear factor erythroid 2-related factor 2 deletion impairs glucose tolerance and exacerbates hyperglycemia in type 1 diabetic mice. Aleksunes L.M., Reisman S.A., Yeager R.L., Goedken M.J., Klaassen C.D.
J. Pharmacol. Exp. Ther. 333:140-151(2010) · Mapped (2) |
| Characterization of peroxisome proliferator-activated receptor alpha--independent effects of PPARalpha activators in the rodent liver: di-(2-ethylhexyl) phthalate also activates the constitutive-activated receptor. Ren H., Aleksunes L.M., Wood C., Vallanat B., George M.H., Klaassen C.D., Corton J.C.
Toxicol. Sci. 113:45-59(2010) · Mapped (6) |
| Tissue distribution, ontogeny, and hormonal regulation of xenobiotic transporters in mouse kidneys. Cheng X., Klaassen C.D.
Drug Metab. Dispos. 37:2178-2185(2009) · Mapped (42) |
| Role of hepatic transporters in prevention of bile acid toxicity after partial hepatectomy in mice. Csanaky I.L., Aleksunes L.M., Tanaka Y., Klaassen C.D.
Am. J. Physiol. Gastrointest. Liver Physiol. 297:G419-33(2009) · Mapped (8) |
| Application of multivariate statistical procedures to identify transcription factors that correlate with MRP2, 3, and 4 mRNA in adult human livers. Aleksunes L.M., Yeager R.L., Klaassen C.D.
Xenobiotica 39:514-522(2009) · Mapped (10) |
| Introducing the "TCDD-inducible AhR-Nrf2 gene battery". Yeager R.L., Reisman S.A., Aleksunes L.M., Klaassen C.D.
Toxicol. Sci. 111:238-246(2009) · Mapped (16) |
