| The extracellular and transmembrane domains of the gammaC and interleukin (IL)-13 receptor alpha1 chains, not their cytoplasmic domains, dictate the nature of signaling responses to IL-4 and IL-13. Heller N.M., Qi X., Gesbert F., Keegan A.D.
J. Biol. Chem. 287:31948-31961(2012) · Mapped (5) |
| IL-4 engagement of the type I IL-4 receptor complex enhances mouse eosinophil migration to eotaxin-1 in vitro. Heller N.M., Gwinn W.M., Donnelly R.P., Constant S.L., Keegan A.D.
PLoS ONE 7:e39673-e39673(2012) · Mapped (6) |
| Insulin receptor substrate 1 expression enhances the sensitivity of 32D cells to chemotherapy-induced cell death. Porter H.A., Carey G.B., Keegan A.D.
Exp. Cell Res. 318:1745-1758(2012) · Mapped (3) |
| Neuroimmune semaphorin 4A downregulates the severity of allergic response. Nkyimbeng-Takwi E.H., Shanks K., Smith E., Iyer A., Lipsky M.M., Detolla L.J., Kikutani H., Keegan A.D., Chapoval S.P.
Mucosal Immunol 5:409-419(2012) · Mapped (1) |
| Transfer of in vivo primed transgenic T cells supports allergic lung inflammation and FIZZ1 and Ym1 production in an IL-4Ralpha and STAT6 dependent manner. Dasgupta P., Chapoval S.P., Smith E.P., Keegan A.D.
BMC Immunol. 12:60-60(2011) · Mapped (4) |
| NF-kappaB signaling participates in both RANKL- and IL-4-induced macrophage fusion: receptor cross-talk leads to alterations in NF-kappaB pathways. Yu M., Qi X., Moreno J.L., Farber D.L., Keegan A.D.
J. Immunol. 187:1797-1806(2011) · Mapped (12) |
| Transcriptional control of rapid recall by memory CD4 T cells. Lai W., Yu M., Huang M.N., Okoye F., Keegan A.D., Farber D.L.
J. Immunol. 187:133-140(2011) · Mapped (7) |
| TLR2 signaling and Th2 responses drive Tannerella forsythia-induced periodontal bone loss. Myneni S.R., Settem R.P., Connell T.D., Keegan A.D., Gaffen S.L., Sharma A.
J. Immunol. 187:501-509(2011) · Mapped (8) |
| Expression of neuroimmune semaphorins 4A and 4D and their receptors in the lung is enhanced by allergen and vascular endothelial growth factor. Smith E.P., Shanks K., Lipsky M.M., DeTolla L.J., Keegan A.D., Chapoval S.P.
BMC Immunol. 12:30-30(2011) · Mapped (5) |
| Alternatively spliced variants of interleukin-4 promote inflammation differentially. Luzina I.G., Lockatell V., Todd N.W., Highsmith K., Keegan A.D., Hasday J.D., Atamas S.P.
J. Leukoc. Biol. 89:763-770(2011) · Mapped (4) |
| STAT6 expression in multiple cell types mediates the cooperative development of allergic airway disease. Chapoval S.P., Dasgupta P., Smith E.P., DeTolla L.J., Lipsky M.M., Kelly-Welch A.E., Keegan A.D.
J. Immunol. 186:2571-2583(2011) · Mapped (5) |
| Control of RSV-induced lung injury by alternatively activated macrophages is IL-4R alpha-, TLR4-, and IFN-beta-dependent. Shirey K.A., Pletneva L.M., Puche A.C., Keegan A.D., Prince G.A., Blanco J.C., Vogel S.N.
Mucosal Immunol 3:291-300(2010) · Mapped (1) |
| Complex regulation of tartrate-resistant acid phosphatase (TRAP) expression by interleukin 4 (IL-4): IL-4 indirectly suppresses receptor activator of NF-kappaB ligand (RANKL)-mediated TRAP expression but modestly induces its expression directly. Yu M., Moreno J.L., Stains J.P., Keegan A.D.
J. Biol. Chem. 284:32968-32979(2009) · Mapped (13) |
| An atopy-associated polymorphism in the ectodomain of the IL-4R(alpha) chain (V50) regulates the persistence of STAT6 phosphorylation. Ford A.Q., Heller N.M., Stephenson L., Boothby M.R., Keegan A.D.
J. Immunol. 183:1607-1616(2009) · Mapped (15) |
| Lung vascular endothelial growth factor expression induces local myeloid dendritic cell activation. Chapoval S.P., Lee C.G., Tang C., Keegan A.D., Cohn L., Bottomly K., Elias J.A.
Clin. Immunol. 132:371-384(2009) · Mapped (5) |
| Type I IL-4Rs selectively activate IRS-2 to induce target gene expression in macrophages. Heller N.M., Qi X., Junttila I.S., Shirey K.A., Vogel S.N., Paul W.E., Keegan A.D.
Sci Signal 1:ra17-ra17(2008) · Mapped (10) |
| Francisella tularensis live vaccine strain induces macrophage alternative activation as a survival mechanism. Shirey K.A., Cole L.E., Keegan A.D., Vogel S.N.
J. Immunol. 181:4159-4167(2008) · Mapped (14) |
| Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system. LaPorte S.L., Juo Z.S., Vaclavikova J., Colf L.A., Qi X., Heller N.M., Keegan A.D., Garcia K.C.
Cell 132:259-272(2008) · UniProtKB (1) · Mapped (15) |
| IL-4 protects the B-cell lymphoma cell line CH31 from anti-IgM-induced growth arrest and apoptosis: contribution of the PI-3 kinase/AKT pathway. Carey G.B., Semenova E., Qi X., Keegan A.D.
Cell Res. 17:942-955(2007) · Mapped (8) |
| IL-4 promotes the formation of multinucleated giant cells from macrophage precursors by a STAT6-dependent, homotypic mechanism: contribution of E-cadherin. Moreno J.L., Mikhailenko I., Tondravi M.M., Keegan A.D.
J. Leukoc. Biol. 82:1542-1553(2007) · Mapped (9) |
| Induction of uteroglobin-related protein 2 (Ugrp2) gene expression by the Th2 cytokines IL-4 and IL-13. Yamada A., Sheikh F., Niimi T., DeMayo F.J., Keegan A.D., Donnelly R.P., Kimura S.
J. Immunol. 175:5708-5715(2005) · Mapped (4) |
| Chronic morphine treatment promotes specific Th2 cytokine production by murine T cells in vitro via a Fas/Fas ligand-dependent mechanism. Greeneltch K.M., Kelly-Welch A.E., Shi Y., Keegan A.D.
J. Immunol. 175:4999-5005(2005) · Mapped (5) |
| Abnormal Th1 cell differentiation and IFN-gamma production in T lymphocytes from motheaten viable mice mutant for Src homology 2 domain-containing protein tyrosine phosphatase-1. Yu W.M., Wang S., Keegan A.D., Williams M.S., Qu C.K.
J. Immunol. 174:1013-1019(2005) · Mapped (11) |
| Increased numbers of committed myeloid progenitors but not primitive hematopoietic stem/progenitors in mice lacking STAT6 expression. Bunting K.D., Yu W.M., Bradley H.L., Haviernikova E., Kelly-Welch A.E., Keegan A.D., Qu C.K.
J. Leukoc. Biol. 76:484-490(2004) · Mapped (4) |
| Complex role of the IL-4 receptor alpha in a murine model of airway inflammation: expression of the IL-4 receptor alpha on nonlymphoid cells of bone marrow origin contributes to severity of inflammation. Kelly-Welch A.E., Melo M.E., Smith E., Ford A.Q., Haudenschild C., Noben-Trauth N., Keegan A.D.
J. Immunol. 172:4545-4555(2004) · Mapped (6) |
