| Structure of a bacterial cytoplasmic cyclophilin A in complex with a tetrapeptide. Christoforides E., Dimou M., Katinakis P., Bethanis K., Karpusas M.
Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 68:259-264(2012) · UniProtKB (1) · Mapped (1) |
| Evaluation of antitumor activity of gefitinib in pediatric glioblastoma and neuroblastoma cells. Hatziagapiou K., Braoudaki M., Karpusas M., Tzortzatou-Stathopoulou F.
Clin. Lab. 57:781-784(2011) · Mapped (19) |
| Discovery of a novel class of non-ATP site DFG-out state p38 inhibitors utilizing computationally assisted virtual fragment-based drug design (vFBDD). Moffett K., Konteatis Z., Nguyen D., Shetty R., Ludington J., Fujimoto T., Lee K.J., Chai X., Namboodiri H., Karpusas M. et al.
Bioorg. Med. Chem. Lett. 21:7155-7165(2011) · Mapped (1) |
| Analysis of imatinib and sorafenib binding to p38alpha compared with c-Abl and b-Raf provides structural insights for understanding the selectivity of inhibitors targeting the DFG-out form of protein kinases. Namboodiri H.V., Bukhtiyarova M., Ramcharan J., Karpusas M., Lee Y., Springman E.B.
Biochemistry 49:3611-3618(2010) · Mapped (1) |
| Frequency of FLT3 mutations in childhood acute lymphoblastic leukemia. Braoudaki M., Karpusas M., Katsibardi K., Papathanassiou C.h., Karamolegou K., Tzortzatou-Stathopoulou F.
Med. Oncol. 26:460-462(2009) · Mapped (2) |
| Mutagenesis of p38alpha MAP kinase establishes key roles of Phe169 in function and structural dynamics and reveals a novel DFG-OUT state. Bukhtiyarova M., Karpusas M., Northrop K., Namboodiri H.V., Springman E.B.
Biochemistry 46:5687-5696(2007) · Mapped (4) |
| Two classes of p38alpha MAP kinase inhibitors having a common diphenylether core but exhibiting divergent binding modes. Michelotti E.L., Moffett K.K., Nguyen D., Kelly M.J., Shetty R., Chai X., Northrop K., Namboodiri V., Campbell B., Flynn G.A. et al.
Bioorg. Med. Chem. Lett. 15:5274-5279(2005) · UniProtKB (1) |
| Structure of a functional fragment of VCAM-1 refined at 1.9-A resolution. Wang J.-H., Stehle T., Pepinsky R.B., Liu J.-H., Karpusas M., Osborn L.
Acta Crystallogr. D 52:369-379(1996) · UniProtKB (1) |
| Crystal structure of the alpha1beta1 integrin I domain in complex with an antibody Fab fragment. Karpusas M., Ferrant J., Weinreb P.H., Carmillo A., Taylor F.R., Garber E.A.
J. Mol. Biol. 327:1031-1041(2003) · Mapped (3) |
| Substitution of Ser for Arg-443 in the regulatory domain of human housekeeping (GLUD1) glutamate dehydrogenase virtually abolishes basal activity and markedly alters the activation of the enzyme by ADP and L-leucine. Zaganas I., Spanaki C., Karpusas M., Plaitakis A.
J. Biol. Chem. 277:46552-46558(2002) · Mapped (12) |
| Crystal structure of extracellular human BAFF, a TNF family member that stimulates B lymphocytes. Karpusas M., Cachero T.G., Qian F., Boriack-Sjodin A., Mullen C., Strauch K., Hsu Y.-M., Kalled S.L.
J. Mol. Biol. 315:1145-1154(2002) · UniProtKB (1) · Mapped (4) |
| Structure of CD40 ligand in complex with the Fab fragment of a neutralizing humanized antibody. Karpusas M., Lucci J., Ferrant J., Benjamin C., Taylor F.R., Strauch K., Garber E., Hsu Y.M.
Structure 9:321-329(2001) · Mapped (1) |
| CD154 variants associated with hyper-IgM syndrome can form oligomers and trigger CD40-mediated signals. Garber E., Su L., Ehrenfels B., Karpusas M., Hsu Y.M.
J. Biol. Chem. 274:33545-33550(1999) · Mapped (5) |
| Crystal structure of the alpha1beta1 integrin I-domain: insights into integrin I-domain function. Nolte M., Pepinsky R.B., Venyaminov S.Y., Koteliansky V., Gotwals P.J., Karpusas M.
FEBS Lett. 452:379-385(1999) · UniProtKB (1) |
| The crystal structure of human interferon beta at 2.2-A resolution. Karpusas M., Nolte M., Benton C.B., Meier W., Lipscomb W.N., Goelz S.
Proc. Natl. Acad. Sci. U.S.A. 94:11813-11818(1997) · UniProtKB (1) |
| The three-dimensional structure of a class I major histocompatibility complex molecule missing the alpha 3 domain of the heavy chain. Collins E.J., Garboczi D.N., Karpusas M.N., Wiley D.C.
Proc. Natl. Acad. Sci. U.S.A. 92:1218-1221(1995) · UniProtKB (2) |
| The crystal structure of an N-terminal two-domain fragment of vascular cell adhesion molecule 1 (VCAM-1): a cyclic peptide based on the domain 1 C-D loop can inhibit VCAM-1-alpha 4 integrin interaction. Wang J.-H., Pepinsky R.B., Stehle T., Liu J.-H., Karpusas M., Browning B., Osborn L.
Proc. Natl. Acad. Sci. U.S.A. 92:5714-5718(1995) · UniProtKB (1) |
| Proposed mechanism for the condensation reaction of citrate synthase: 1.9-A structure of the ternary complex with oxaloacetate and carboxymethyl coenzyme A. Karpusas M., Branchaud B., Remington S.J.
Biochemistry 29:2213-2219(1990) · UniProtKB (1) |
| Crystal structure of an open conformation of citrate synthase from chicken heart at 2.8-A resolution. Liao D.-I., Karpusas M., Remington S.J.
Biochemistry 30:6031-6036(1991) · UniProtKB (1) |
| 1.9-A structures of ternary complexes of citrate synthase with D- and L-malate: mechanistic implications. Karpusas M., Holland D., Remington S.J.
Biochemistry 30:6024-6031(1991) · Mapped (1) |
