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1 - 25 of 36 results for author:"Isom L.L." in Literature citations

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Identification of the cysteine residue responsible for disulfide linkage of Na+ channel alpha and beta2 subunits.

Chen C., Calhoun J.D., Zhang Y., Lopez-Santiago L., Zhou N., Davis T.H., Salzer J.L., Isom L.L.

J. Biol. Chem. 287:39061-39069(2012) · UniProtKB (1) · Mapped (7)

The sodium channel accessory subunit Navbeta1 regulates neuronal excitability through modulation of repolarizing voltage-gated K⁺ channels.

Marionneau C., Carrasquillo Y., Norris A.J., Townsend R.R., Isom L.L., Link A.J., Nerbonne J.M.

J. Neurosci. 32:5716-5727(2012) · Mapped (2)

Voltage-gated Na+ channel beta1B: a secreted cell adhesion molecule involved in human epilepsy.

Patino G.A., Brackenbury W.J., Bao Y., Lopez-Santiago L.F., O'Malley H.A., Chen C., Calhoun J.D., Lafreniere R.G., Cossette P., Rouleau G.A. et al.

J. Neurosci. 31:14577-14591(2011) · UniProtKB (1)

Interactions between ankyrin-G, Plakophilin-2, and Connexin43 at the cardiac intercalated disc.

Sato P.Y., Coombs W., Lin X., Nekrasova O., Green K.J., Isom L.L., Taffet S.M., Delmar M.

Circ. Res. 109:193-201(2011) · Mapped (17)

Na+ channel Scn1b gene regulates dorsal root ganglion nociceptor excitability in vivo.

Lopez-Santiago L.F., Brackenbury W.J., Chen C., Isom L.L.

J. Biol. Chem. 286:22913-22923(2011) · Mapped (1)

Efficacy loss of the anticonvulsant carbamazepine in mice lacking sodium channel beta subunits via paradoxical effects on persistent sodium currents.

Uebachs M., Opitz T., Royeck M., Dickhof G., Horstmann M.T., Isom L.L., Beck H.

J. Neurosci. 30:8489-8501(2010) · Mapped (3)

Ordered assembly of the adhesive and electrochemical connections within newly formed intercalated disks in primary cultures of adult rat cardiomyocytes.

Geisler S.B., Green K.J., Isom L.L., Meshinchi S., Martens J.R., Delmar M., Russell M.W.

J. Biomed. Biotechnol. 2010:624719-624719(2010) · Mapped (7)

Functional reciprocity between Na+ channel Nav1.6 and beta1 subunits in the coordinated regulation of excitability and neurite outgrowth.

Brackenbury W.J., Calhoun J.D., Chen C., Miyazaki H., Nukina N., Oyama F., Ranscht B., Isom L.L.

Proc. Natl. Acad. Sci. U.S.A. 107:2283-2288(2010) · Mapped (11)

Conduction block in PMP22 deficiency.

Bai Y., Zhang X., Katona I., Saporta M.A., Shy M.E., O'Malley H.A., Isom L.L., Suter U., Li J.

J. Neurosci. 30:600-608(2010) · Mapped (11)

A functional null mutation of SCN1B in a patient with Dravet syndrome.

Patino G.A., Claes L.R., Lopez-Santiago L.F., Slat E.A., Dondeti R.S., Chen C., O'Malley H.A., Gray C.B., Miyazaki H., Nukina N. et al.

J. Neurosci. 29:10764-10778(2009) · Mapped (5)

Loss of plakophilin-2 expression leads to decreased sodium current and slower conduction velocity in cultured cardiac myocytes.

Sato P.Y., Musa H., Coombs W., Guerrero-Serna G., Patino G.A., Taffet S.M., Isom L.L., Delmar M.

Circ. Res. 105:523-526(2009) · Mapped (5)

The voltage-gated Na+ channel beta3 subunit does not mediate trans homophilic cell adhesion or associate with the cell adhesion molecule contactin.

McEwen D.P., Chen C., Meadows L.S., Lopez-Santiago L., Isom L.L.

Neurosci. Lett. 462:272-275(2009) · Mapped (1)

Regulation of persistent Na current by interactions between beta subunits of voltage-gated Na channels.

Aman T.K., Grieco-Calub T.M., Chen C., Rusconi R., Slat E.A., Isom L.L., Raman I.M.

J. Neurosci. 29:2027-2042(2009) · Mapped (3)

scn1bb, a zebrafish ortholog of SCN1B expressed in excitable and nonexcitable cells, affects motor neuron axon morphology and touch sensitivity.

Fein A.J., Wright M.A., Slat E.A., Ribera A.B., Isom L.L.

J. Neurosci. 28:12510-12522(2008) · UniProtKB (1) · Mapped (1)

Loss of Na+ channel beta2 subunits is neuroprotective in a mouse model of multiple sclerosis.

O'Malley H.A., Shreiner A.B., Chen G.H., Huffnagle G.B., Isom L.L.

Mol. Cell. Neurosci. 40:143-155(2009) · Mapped (2)

Voltage-gated Na+ channel beta1 subunit-mediated neurite outgrowth requires Fyn kinase and contributes to postnatal CNS development in vivo.

Brackenbury W.J., Davis T.H., Chen C., Slat E.A., Detrow M.J., Dickendesher T.L., Ranscht B., Isom L.L.

J. Neurosci. 28:3246-3256(2008) · Mapped (8)

Sodium channel Scn1b null mice exhibit prolonged QT and RR intervals.

Lopez-Santiago L.F., Meadows L.S., Ernst S.J., Chen C., Malhotra J.D., McEwen D.P., Speelman A., Noebels J.L., Maier S.K., Lopatin A.N. et al.

J. Mol. Cell. Cardiol. 43:636-647(2007) · Mapped (41)

Floxed allele for conditional inactivation of the voltage-gated sodium channel beta1 subunit Scn1b.

Chen C., Dickendesher T.L., Oyama F., Miyazaki H., Nukina N., Isom L.L.

Genesis 45:547-553(2007) · Mapped (1)

Cloning and expression of a zebrafish SCN1B ortholog and identification of a species-specific splice variant.

Fein A.J., Meadows L.S., Chen C., Slat E.A., Isom L.L.

BMC Genomics 8:226-226(2007) · Mapped (6)

Sodium channel beta2 subunits regulate tetrodotoxin-sensitive sodium channels in small dorsal root ganglion neurons and modulate the response to pain.

Lopez-Santiago L.F., Pertin M., Morisod X., Chen C., Hong S., Wiley J., Decosterd I., Isom L.L.

J. Neurosci. 26:7984-7994(2006) · Mapped (2)

Upregulation of the voltage-gated sodium channel beta2 subunit in neuropathic pain models: characterization of expression in injured and non-injured primary sensory neurons.

Pertin M., Ji R.R., Berta T., Powell A.J., Karchewski L., Tate S.N., Isom L.L., Woolf C.J., Gilliard N., Spahn D.R. et al.

J. Neurosci. 25:10970-10980(2005) · Mapped (2)

Open-channel block by the cytoplasmic tail of sodium channel beta4 as a mechanism for resurgent sodium current.

Grieco T.M., Malhotra J.D., Chen C., Isom L.L., Raman I.M.

Neuron 45:233-244(2005) · Mapped (3)

A novel epilepsy mutation in the sodium channel SCN1A identifies a cytoplasmic domain for beta subunit interaction.

Spampanato J., Kearney J.A., de Haan G., McEwen D.P., Escayg A., Aradi I., MacDonald B.T., Levin S.I., Soltesz I., Benna P. et al.

J. Neurosci. 24:10022-10034(2004) · UniProtKB (1) · Mapped (6)

Sodium channel beta1 subunits promote neurite outgrowth in cerebellar granule neurons.

Davis T.H., Chen C., Isom L.L.

J. Biol. Chem. 279:51424-51432(2004) · Mapped (4)

Tyrosine-phosphorylated and nonphosphorylated sodium channel beta1 subunits are differentially localized in cardiac myocytes.

Malhotra J.D., Thyagarajan V., Chen C., Isom L.L.

J. Biol. Chem. 279:40748-40754(2004) · Mapped (34)

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