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Docosahexaenoic acid attenuates microglial activation and delays early retinal degeneration.

Ebert S., Weigelt K., Walczak Y., Drobnik W., Mauerer R., Hume D.A., Weber B.H., Langmann T.

J. Neurochem. 110:1863-1875(2009) · Mapped (2)

Tiny RNAs associated with transcription start sites in animals.

Taft R.J., Glazov E.A., Cloonan N., Simons C., Stephen S., Faulkner G.J., Lassmann T., Forrest A.R., Grimmond S.M., Schroder K. et al.

Nat. Genet. 41:572-578(2009) · Mapped (19)

CX3CR1+ CD115+ CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation.

Auffray C., Fogg D.K., Narni-Mancinelli E., Senechal B., Trouillet C., Saederup N., Leemput J., Bigot K., Campisi L., Abitbol M. et al.

J. Exp. Med. 206:595-606(2009) · Mapped (22)

CD148/DEP-1 association with areas of cytoskeletal organisation in macrophages.

Dave R.K., Hume D.A., Elsegood C., Kellie S.

Exp. Cell Res. 315:1734-1744(2009) · Mapped (10)

HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA.

Roberts T.L., Idris A., Dunn J.A., Kelly G.M., Burnton C.M., Hodgson S., Hardy L.L., Garceau V., Sweet M.J., Ross I.L. et al.

Science 323:1057-1060(2009) · Mapped (3)

Colony-stimulating factor-1 (CSF-1) delivers a proatherogenic signal to human macrophages.

Irvine K.M., Andrews M.R., Fernandez-Rojo M.A., Schroder K., Burns C.J., Su S., Wilks A.F., Parton R.G., Hume D.A., Sweet M.J.

J. Leukoc. Biol. 85:278-288(2009) · Mapped (4)

The macrophage-inducible C-type lectin, mincle, is an essential component of the innate immune response to Candida albicans.

Wells C.A., Salvage-Jones J.A., Li X., Hitchens K., Butcher S., Murray R.Z., Beckhouse A.G., Lo Y.L., Manzanero S., Cobbold C. et al.

J. Immunol. 180:7404-7413(2008) · Mapped (3)

The Ewing sarcoma protein (EWS) binds directly to the proximal elements of the macrophage-specific promoter of the CSF-1 receptor (csf1r) gene.

Hume D.A., Sasmono T., Himes S.R., Sharma S.M., Bronisz A., Constantin M., Ostrowski M.C., Ross I.L.

J. Immunol. 180:6733-6742(2008) · Mapped (26)

Cortactin adopts a globular conformation and bundles actin into sheets.

Cowieson N.P., King G., Cookson D., Ross I., Huber T., Hume D.A., Kobe B., Martin J.L.

J. Biol. Chem. 283:16187-16193(2008) · Mapped (4)

Monomeric tartrate resistant acid phosphatase induces insulin sensitive obesity.

Lang P., van Harmelen V., Ryden M., Kaaman M., Parini P., Carneheim C., Cassady A.I., Hume D.A., Andersson G., Arner P.

PLoS ONE 3:e1713-e1713(2008) · Mapped (4)

Microphthalmia transcription factor regulates the expression of the novel osteoclast factor GPNMB.

Ripoll V.M., Meadows N.A., Raggatt L.J., Chang M.K., Pettit A.R., Cassady A.I., Hume D.A.

Gene 413:32-41(2008) · Mapped (14)

The transcriptional regulation of the Colony-Stimulating Factor 1 Receptor (csf1r) gene during hematopoiesis.

Bonifer C., Hume D.A.

Front. Biosci. 13:549-560(2008) · Mapped (8)

Differential effects of CpG DNA on IFN-beta induction and STAT1 activation in murine macrophages versus dendritic cells: alternatively activated STAT1 negatively regulates TLR signaling in macrophages.

Schroder K., Spille M., Pilz A., Lattin J., Bode K.A., Irvine K.M., Burrows A.D., Ravasi T., Weighardt H., Stacey K.J. et al.

J. Immunol. 179:3495-3503(2007) · Mapped (2)

Histone deacetylase inhibitors decrease Toll-like receptor-mediated activation of proinflammatory gene expression by impairing transcription factor recruitment.

Bode K.A., Schroder K., Hume D.A., Ravasi T., Heeg K., Sweet M.J., Dalpke A.H.

Immunology 122:596-606(2007) · Mapped (12)

Structural basis for recruitment of tandem hotdog domains in acyl-CoA thioesterase 7 and its role in inflammation.

Forwood J.K., Thakur A.S., Guncar G., Marfori M., Mouradov D., Meng W., Robinson J., Huber T., Kellie S., Martin J.L. et al.

Proc. Natl. Acad. Sci. U.S.A. 104:10382-10387(2007) · Mapped (1)

Gpnmb is induced in macrophages by IFN-gamma and lipopolysaccharide and acts as a feedback regulator of proinflammatory responses.

Ripoll V.M., Irvine K.M., Ravasi T., Sweet M.J., Hume D.A.

J. Immunol. 178:6557-6566(2007) · Mapped (8)

Mouse neutrophilic granulocytes express mRNA encoding the macrophage colony-stimulating factor receptor (CSF-1R) as well as many other macrophage-specific transcripts and can transdifferentiate into macrophages in vitro in response to CSF-1.

Sasmono R.T., Ehrnsperger A., Cronau S.L., Ravasi T., Kandane R., Hickey M.J., Cook A.D., Himes S.R., Hamilton J.A., Hume D.A.

J. Leukoc. Biol. 82:111-123(2007) · Mapped (19)

PU.1 and ICSBP control constitutive and IFN-gamma-regulated Tlr9 gene expression in mouse macrophages.

Schroder K., Lichtinger M., Irvine K.M., Brion K., Trieu A., Ross I.L., Ravasi T., Stacey K.J., Rehli M., Hume D.A. et al.

J. Leukoc. Biol. 81:1577-1590(2007) · Mapped (3)

The expression of Clcn7 and Ostm1 in osteoclasts is coregulated by microphthalmia transcription factor.

Meadows N.A., Sharma S.M., Faulkner G.J., Ostrowski M.C., Hume D.A., Cassady A.I.

J. Biol. Chem. 282:1891-1904(2007) · Mapped (6)

Histone deacetylase inhibitor reduces monocyte adhesion to endothelium through the suppression of vascular cell adhesion molecule-1 expression.

Inoue K., Kobayashi M., Yano K., Miura M., Izumi A., Mataki C., Doi T., Hamakubo T., Reid P.C., Hume D.A. et al.

Arterioscler. Thromb. Vasc. Biol. 26:2652-2659(2006) · Mapped (34)

CpG DNA activates survival in murine macrophages through TLR9 and the phosphatidylinositol 3-kinase-Akt pathway.

Sester D.P., Brion K., Trieu A., Goodridge H.S., Roberts T.L., Dunn J., Hume D.A., Stacey K.J., Sweet M.J.

J. Immunol. 177:4473-4480(2006) · Mapped (1)

Macrophage-specific expression of human lysosomal acid lipase corrects inflammation and pathogenic phenotypes in lal-/- mice.

Yan C., Lian X., Li Y., Dai Y., White A., Qin Y., Li H., Hume D.A., Du H.

Am. J. Pathol. 169:916-926(2006) · Mapped (4)

A CSF-1 receptor kinase inhibitor targets effector functions and inhibits pro-inflammatory cytokine production from murine macrophage populations.

Irvine K.M., Burns C.J., Wilks A.F., Su S., Hume D.A., Sweet M.J.

FASEB J. 20:1921-1923(2006) · Mapped (19)

Identification and molecular modeling of a novel, plant-like, human purple acid phosphatase.

Flanagan J.U., Cassady A.I., Schenk G., Guddat L.W., Hume D.A.

Gene 377:12-20(2006) · UniProtKB (1)

Antisense transcription in the mammalian transcriptome.

FANTOM Consortium

Science 309:1564-1566(2005) · UniProtKB (18,611)

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