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Cyclin-dependent kinase 5 is a calmodulin-binding protein that associates with puromycin-sensitive aminopeptidase in the nucleus of Dictyostelium.

Huber R.J., Catalano A., O'Day D.H.

Biochim. Biophys. Acta 1833:11-20(2013)

Human high temperature requirement serine protease A1 (HTRA1) degrades tau protein aggregates.

Tennstaedt A., Popsel S., Truebestein L., Hauske P., Brockmann A., Schmidt N., Irle I., Sacca B., Niemeyer C.M., Brandt R. et al.

J. Biol. Chem. 287:20931-20941(2012) · Mapped (10)

Substitution for Asn460 cripples beta-galactosidase (Escherichia coli) by increasing substrate affinity and decreasing transition state stability.

Wheatley R.W., Kappelhoff J.C., Hahn J.N., Dugdale M.L., Dutkoski M.J., Tamman S.D., Fraser M.E., Huber R.E.

Arch. Biochem. Biophys. 521:51-61(2012) · Mapped (1)

Regulation of C/EBPbeta and resulting functions in cells of the monocytic lineage.

Huber R., Pietsch D., Panterodt T., Brand K.

Cell. Signal. 24:1287-1296(2012) · Mapped (3)

Basal HIF-1alpha expression levels are not predictive for radiosensitivity of human cancer cell lines.

Schilling D., Bayer C., Emmerich K., Molls M., Vaupel P., Huber R.M., Multhoff G.

Strahlenther Onkol 188:353-358(2012) · Mapped (9)

Ser-796 of beta-galactosidase (Escherichia coli) plays a key role in maintaining a balance between the opened and closed conformations of the catalytically important active site loop.

Jancewicz L.J., Wheatley R.W., Sutendra G., Lee M., Fraser M.E., Huber R.E.

Arch. Biochem. Biophys. 517:111-122(2012) · Mapped (1)

Structure of the stapled p53 peptide bound to Mdm2.

Baek S., Kutchukian P.S., Verdine G.L., Huber R., Holak T.A., Lee K.W., Popowicz G.M.

J. Am. Chem. Soc. 134:103-106(2012) · Mapped (1)

Molecular architecture of the Spire-actin nucleus and its implication for actin filament assembly.

Sitar T., Gallinger J., Ducka A.M., Ikonen T.P., Wohlhoefler M., Schmoller K.M., Bausch A.R., Joel P., Trybus K.M., Noegel A.A. et al.

Proc. Natl. Acad. Sci. U.S.A. 108:19575-19580(2011) · Mapped (5)

Hydroxyureas as noncovalent proteasome inhibitors.

Gallastegui N., Beck P., Arciniega M., Huber R., Hillebrand S., Groll M.

Angew. Chem. Int. Ed. Engl. 51:247-249(2012) · Mapped (14)

The structure of CDK8/CycC implicates specificity in the CDK/cyclin family and reveals interaction with a deep pocket binder.

Schneider E.V., Bottcher J., Blaesse M., Neumann L., Huber R., Maskos K.

J. Mol. Biol. 412:251-266(2011) · UniProtKB (2) · Mapped (8)

Milk lacking alpha-casein leads to permanent reduction in body size in mice.

Kolb A.F., Huber R.C., Lillico S.G., Carlisle A., Robinson C.J., Neil C., Petrie L., Sorensen D.B., Olsson I.A., Whitelaw C.B.

PLoS ONE 6:e21775-e21775(2011) · Mapped (5)

Nucleocytoplasmic transfer of cyclin dependent kinase 5 and its binding to puromycin-sensitive aminopeptidase in Dictyostelium discoideum.

Huber R.J., O'Day D.H.

Histochem. Cell Biol. 136:177-189(2011)

CCAAT/enhancer-binding protein beta inhibits proliferation in monocytic cells by affecting the retinoblastoma protein/E2F/cyclin E pathway but is not directly required for macrophage morphology.

Gutsch R., Kandemir J.D., Pietsch D., Cappello C., Meyer J., Simanowski K., Huber R., Brand K.

J. Biol. Chem. 286:22716-22729(2011) · Mapped (25)

An extracellular matrix, calmodulin-binding protein from Dictyostelium with EGF-like repeats that enhance cell motility.

Suarez A., Huber R.J., Myre M.A., O'Day D.H.

Cell. Signal. 23:1197-1206(2011)

Elucidation of the alpha-keto-aldehyde binding mechanism: a lead structure motif for proteasome inhibition.

Grawert M.A., Gallastegui N., Stein M., Schmidt B., Kloetzel P.M., Huber R., Groll M.

Angew. Chem. Int. Ed. Engl. 50:542-544(2011) · Mapped (14)

Importance of Arg-599 of beta-galactosidase (Escherichia coli) as an anchor for the open conformations of Phe-601 and the active-site loop.

Dugdale M.L., Vance M.L., Wheatley R.W., Driedger M.R., Nibber A., Tran A., Huber R.E.

Biochem. Cell Biol. 88:969-979(2010) · Mapped (1)

The GTPase RAB20 is a HIF target with mitochondrial localization mediating apoptosis in hypoxia.

Hackenbeck T., Huber R., Schietke R., Knaup K.X., Monti J., Wu X., Klanke B., Frey B., Gaipl U., Wullich B. et al.

Biochim. Biophys. Acta 1813:1-13(2011) · Mapped (7)

Role of Met-542 as a guide for the conformational changes of Phe-601 that occur during the reaction of β-galactosidase (Escherichia coli).

Dugdale M.L., Dymianiw D.L., Minhas B.K., D'Angelo I., Huber R.E.

Biochem. Cell Biol. 88:861-869(2010) · Mapped (1)

Effects of cigarette smoke extract and nicotine on bronchial tone and acetylcholine-induced airway contraction in mouse lung slices.

Streck E., Jorres R.A., Huber R.M., Bergner A.

J Investig Allergol Clin Immunol 20:324-330(2010) · Mapped (3)

20S proteasome inhibition: designing noncovalent linear peptide mimics of the natural product TMC-95A.

Groll M., Gallastegui N., Marechal X., Le Ravalec V., Basse N., Richy N., Genin E., Huber R., Moroder L., Vidal J. et al.

ChemMedChem 5:1701-1705(2010) · Mapped (14)

HtrA proteases have a conserved activation mechanism that can be triggered by distinct molecular cues.

Krojer T., Sawa J., Huber R., Clausen T.

Nat. Struct. Mol. Biol. 17:844-852(2010) · UniProtKB (1)

Structures of actin-bound Wiskott-Aldrich syndrome protein homology 2 (WH2) domains of Spire and the implication for filament nucleation.

Ducka A.M., Joel P., Popowicz G.M., Trybus K.M., Schleicher M., Noegel A.A., Huber R., Holak T.A., Sitar T.

Proc. Natl. Acad. Sci. U.S.A. 107:11757-11762(2010) · UniProtKB (1) · Mapped (6)

Functional characterization of a partial loss-of-function mutation of the epithelial sodium channel (ENaC) associated with atypical cystic fibrosis.

Huber R., Krueger B., Diakov A., Korbmacher J., Haerteis S., Einsiedel J., Gmeiner P., Azad A.K., Cuppens H., Cassiman J.J. et al.

Cell. Physiol. Biochem. 25:145-158(2010) · Mapped (5)

Studies of Glu-416 variants of beta-galactosidase (E. coli) show that the active site Mg(2+) is not important for structure and indicate that the main role of Mg (2+) is to mediate optimization of active site chemistry.

Lo S., Dugdale M.L., Jeerh N., Ku T., Roth N.J., Huber R.E.

Protein J. 29:26-31(2010) · Mapped (1)

GSK3beta regulates differentiation and growth arrest in glioblastoma.

Korur S., Huber R.M., Sivasankaran B., Petrich M., Morin P. Jr., Hemmings B.A., Merlo A., Lino M.M.

PLoS ONE 4:e7443-e7443(2009) · Mapped (4)

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